<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10133668> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/dc/terms/title> "Neurofilament results for the phase II neuroprotection study of phenytoin in optic neuritis"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/ontology/bibo/abstract> "Background:\r\nA randomized trial of phenytoin in acute optic neuritis (ON) demonstrated a 30% reduction in retinal nerve fiber layer (RNFL) loss with phenytoin versus placebo. Here we present the corresponding serum neurofilament analyses.\r\n\r\nMethods:\r\nEighty-six acute ON cases were randomized to receive phenytoin (4–6 mg/kg/day) or placebo for 3 months, and followed up for 6 months. Serum was collected at baseline, 3 and 6 months for analysis of neurofilament heavy chain (NfH) and neurofilament light chain (NfL).\r\n\r\nResults:\r\nSixty-four patients had blood sampling. Of these, 58 and 56 were available at 3 months, and 55 and 54 were available at 6 months for NfH and NfL, respectively. There was no significant correlation between serum NfH and NfL at the time points tested. For NfH, the difference in mean placebo – phenytoin was −44 pg/ml at 3 months (P = 0.019) and −27 pg/ml at 6 months (P = 0.234). For NfL, the difference was 1.4 pg/ml at 3 months (P = 0.726) and −1.6 pg/ml at 6 months (P = 0.766).\r\n\r\nConclusions:\r\nAt 3 months, there was a reduction in NfH, but not NFL, in the phenytoin versus placebo group, while differences at 6 months were not statistically significant. This suggests a potential neuroprotective role for phenytoin in acute ON, with the lower NfH at 3 months, when levels secondary to degeneration of the anterior visual pathway are still elevated, but not at 6 months, when levels have normalized."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/dc/terms/date> "2021-02" . <https://discovery.ucl.ac.uk/id/document/1363623> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/ontology/bibo/volume> "28" . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/ontology/bibo/issue> "2" . <https://discovery.ucl.ac.uk/id/org/ext-69575aab272d692ae22e92dad044c2a2> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-69575aab272d692ae22e92dad044c2a2> <http://xmlns.com/foaf/0.1/name> "WILEY"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-69575aab272d692ae22e92dad044c2a2> . <https://discovery.ucl.ac.uk/id/publication/ext-14681331> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-14681331> <http://xmlns.com/foaf/0.1/name> "European Journal of Neurology"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-14681331> . <https://discovery.ucl.ac.uk/id/publication/ext-14681331> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:14681331> . <https://discovery.ucl.ac.uk/id/publication/ext-14681331> <http://purl.org/ontology/bibo/issn> "14681331" . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-80c3752d9caa7195cafcf31674640d42> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> . <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-80c3752d9caa7195cafcf31674640d42> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3f42adaf5956de3b175c46341ec22d49> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> . <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-3f42adaf5956de3b175c46341ec22d49> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ca4d837becddf529a92a03188e4488fe> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> . <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-ca4d837becddf529a92a03188e4488fe> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f51281ebc7a3326430ed7a46da0b6ef7> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> . <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-f51281ebc7a3326430ed7a46da0b6ef7> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-646d9d906ed92282b51bf902fbdbe72b> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> . <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-646d9d906ed92282b51bf902fbdbe72b> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fd82aa2ea55e22b1783a93a5f3ef69bf> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> . <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-fd82aa2ea55e22b1783a93a5f3ef69bf> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2745f6661a75d7d2332f6fd02654d553> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> . <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-2745f6661a75d7d2332f6fd02654d553> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a5cafcbd5c23566fa11e6a46467e07da> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> . <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-a5cafcbd5c23566fa11e6a46467e07da> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6ddb43b00ab681faf529c214c0c5be26> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> . <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-6ddb43b00ab681faf529c214c0c5be26> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-93717584a50e134f40afce9fd1f1d16c> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> . <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-93717584a50e134f40afce9fd1f1d16c> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bd7ecb3951449074fdbb22bc842933a7> . <https://discovery.ucl.ac.uk/id/eprint/10133668> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> . <https://discovery.ucl.ac.uk/id/eprint/10133668#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-bd7ecb3951449074fdbb22bc842933a7> . <https://discovery.ucl.ac.uk/id/person/ext-2745f6661a75d7d2332f6fd02654d553> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-2745f6661a75d7d2332f6fd02654d553> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2745f6661a75d7d2332f6fd02654d553> <http://xmlns.com/foaf/0.1/familyName> "Blennow"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2745f6661a75d7d2332f6fd02654d553> <http://xmlns.com/foaf/0.1/name> "K Blennow"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f51281ebc7a3326430ed7a46da0b6ef7> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-f51281ebc7a3326430ed7a46da0b6ef7> <http://xmlns.com/foaf/0.1/givenName> "SJ"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f51281ebc7a3326430ed7a46da0b6ef7> <http://xmlns.com/foaf/0.1/familyName> "Hickman"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f51281ebc7a3326430ed7a46da0b6ef7> <http://xmlns.com/foaf/0.1/name> "SJ Hickman"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-93717584a50e134f40afce9fd1f1d16c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-93717584a50e134f40afce9fd1f1d16c> <http://xmlns.com/foaf/0.1/givenName> "G"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-93717584a50e134f40afce9fd1f1d16c> <http://xmlns.com/foaf/0.1/familyName> "Giovannoni"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-93717584a50e134f40afce9fd1f1d16c> <http://xmlns.com/foaf/0.1/name> "G Giovannoni"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3f42adaf5956de3b175c46341ec22d49> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-3f42adaf5956de3b175c46341ec22d49> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3f42adaf5956de3b175c46341ec22d49> <http://xmlns.com/foaf/0.1/familyName> "Kuhle"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3f42adaf5956de3b175c46341ec22d49> <http://xmlns.com/foaf/0.1/name> "J Kuhle"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-80c3752d9caa7195cafcf31674640d42> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-80c3752d9caa7195cafcf31674640d42> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-80c3752d9caa7195cafcf31674640d42> <http://xmlns.com/foaf/0.1/familyName> "Raftopoulos"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-80c3752d9caa7195cafcf31674640d42> <http://xmlns.com/foaf/0.1/name> "R Raftopoulos"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-646d9d906ed92282b51bf902fbdbe72b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-646d9d906ed92282b51bf902fbdbe72b> <http://xmlns.com/foaf/0.1/givenName> "DR"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-646d9d906ed92282b51bf902fbdbe72b> <http://xmlns.com/foaf/0.1/familyName> "Altmann"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-646d9d906ed92282b51bf902fbdbe72b> <http://xmlns.com/foaf/0.1/name> "DR Altmann"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ca4d837becddf529a92a03188e4488fe> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-ca4d837becddf529a92a03188e4488fe> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ca4d837becddf529a92a03188e4488fe> <http://xmlns.com/foaf/0.1/familyName> "Grant"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ca4d837becddf529a92a03188e4488fe> <http://xmlns.com/foaf/0.1/name> "D Grant"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6ddb43b00ab681faf529c214c0c5be26> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-6ddb43b00ab681faf529c214c0c5be26> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6ddb43b00ab681faf529c214c0c5be26> <http://xmlns.com/foaf/0.1/familyName> "Kapoor"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6ddb43b00ab681faf529c214c0c5be26> <http://xmlns.com/foaf/0.1/name> "R Kapoor"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-fd82aa2ea55e22b1783a93a5f3ef69bf> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-fd82aa2ea55e22b1783a93a5f3ef69bf> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-fd82aa2ea55e22b1783a93a5f3ef69bf> <http://xmlns.com/foaf/0.1/familyName> "Leppert"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-fd82aa2ea55e22b1783a93a5f3ef69bf> <http://xmlns.com/foaf/0.1/name> "D Leppert"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a5cafcbd5c23566fa11e6a46467e07da> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-a5cafcbd5c23566fa11e6a46467e07da> 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