eprintid: 10133404
rev_number: 18
eprint_status: archive
userid: 608
dir: disk0/10/13/34/04
datestamp: 2021-08-31 11:20:40
lastmod: 2021-09-23 22:21:12
status_changed: 2021-08-31 11:20:40
type: article
metadata_visibility: show
creators_name: Slator, PJ
creators_name: Palombo, M
creators_name: Miller, KL
creators_name: Westin, C-F
creators_name: Laun, F
creators_name: Kim, D
creators_name: Haldar, JP
creators_name: Benjamini, D
creators_name: Lemberskiy, G
creators_name: de Almeida Martins, JP
creators_name: Hutter, J
title: Combined diffusion-relaxometry microstructure imaging: Current status and future prospects
ispublished: inpress
divisions: UCL
divisions: B04
divisions: C05
divisions: F48
keywords: diffusion, multidimensional MRI, quantitative MRI, relaxometry
note: © 2021 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
abstract: Microstructure imaging seeks to noninvasively measure and map microscopic tissue features by pairing mathematical modeling with tailored MRI protocols. This article reviews an emerging paradigm that has the potential to provide a more detailed assessment of tissue microstructure—combined diffusion-relaxometry imaging. Combined diffusion-relaxometry acquisitions vary multiple MR contrast encodings—such as b-value, gradient direction, inversion time, and echo time—in a multidimensional acquisition space. When paired with suitable analysis techniques, this enables quantification of correlations and coupling between multiple MR parameters—such as diffusivity, T_{1}, T_{2}, and T_{3}*.  This opens the possibility of disentangling multiple tissue compartments (within voxels) that are indistinguishable with single-contrast scans, enabling a new generation of microstructural maps with improved biological sensitivity and specificity.
date: 2021-08-19
publisher: WILEY
official_url: https://doi.org/10.1002/mrm.28963
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1883327
doi: 10.1002/mrm.28963
lyricists_name: Palombo, Marco
lyricists_name: Slator, Patrick
lyricists_id: MPALO05
lyricists_id: PJSLA44
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Magnetic Resonance in Medicine
pages: 25
citation:        Slator, PJ;    Palombo, M;    Miller, KL;    Westin, C-F;    Laun, F;    Kim, D;    Haldar, JP;                 ... Hutter, J; + view all <#>        Slator, PJ;  Palombo, M;  Miller, KL;  Westin, C-F;  Laun, F;  Kim, D;  Haldar, JP;  Benjamini, D;  Lemberskiy, G;  de Almeida Martins, JP;  Hutter, J;   - view fewer <#>    (2021)    Combined diffusion-relaxometry microstructure imaging: Current status and future prospects.                   Magnetic Resonance in Medicine        10.1002/mrm.28963 <https://doi.org/10.1002/mrm.28963>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10133404/1/mrm.28963.pdf