TY  - INPR
EP  - 25
Y1  - 2021/08/19/
AV  - public
TI  - Combined diffusion-relaxometry microstructure imaging: Current status and future prospects
N1  - © 2021 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
PB  - WILEY
UR  - https://doi.org/10.1002/mrm.28963
ID  - discovery10133404
N2  - Microstructure imaging seeks to noninvasively measure and map microscopic tissue features by pairing mathematical modeling with tailored MRI protocols. This article reviews an emerging paradigm that has the potential to provide a more detailed assessment of tissue microstructure?combined diffusion-relaxometry imaging. Combined diffusion-relaxometry acquisitions vary multiple MR contrast encodings?such as b-value, gradient direction, inversion time, and echo time?in a multidimensional acquisition space. When paired with suitable analysis techniques, this enables quantification of correlations and coupling between multiple MR parameters?such as diffusivity, T_{1}, T_{2}, and T_{3}*.  This opens the possibility of disentangling multiple tissue compartments (within voxels) that are indistinguishable with single-contrast scans, enabling a new generation of microstructural maps with improved biological sensitivity and specificity.
KW  - diffusion
KW  -  multidimensional MRI
KW  -  quantitative MRI
KW  -  relaxometry
A1  - Slator, PJ
A1  - Palombo, M
A1  - Miller, KL
A1  - Westin, C-F
A1  - Laun, F
A1  - Kim, D
A1  - Haldar, JP
A1  - Benjamini, D
A1  - Lemberskiy, G
A1  - de Almeida Martins, JP
A1  - Hutter, J
JF  - Magnetic Resonance in Medicine
ER  -