eprintid: 10133294 rev_number: 29 eprint_status: archive userid: 608 dir: disk0/10/13/32/94 datestamp: 2021-09-10 15:26:03 lastmod: 2021-12-10 00:56:39 status_changed: 2021-09-10 15:26:03 type: article metadata_visibility: show creators_name: Mirza, A creators_name: Yorke-Edwards, V creators_name: Lensen, S creators_name: Murray, ML creators_name: Diaz-Montana, C creators_name: Carpenter, J creators_name: Sydes, MR creators_name: Love, SB title: Why are feasibility studies accessing routinely collected health data? A systematic review ispublished: pub divisions: UCL divisions: B02 divisions: D65 divisions: J38 keywords: Feasibility trial, pilot trial, systematic review, routinely-collected health data, registry, RCT, electronic health record note: © 2021 Mirza A et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. abstract: BACKGROUND: Feasibility trials are often undertaken to determine whether a larger randomised controlled trial (RCT) is achievable. In a recent review, 15 feasibility trials accessed routinely collected health data (RCHD) from UK national databases and registries. This paper looks at attributes of these trials and the reasons why they accessed RCHD. METHODS: We extracted data from all publicly available sources for the 15 feasibility studies found in a previous review of trials successfully accessing RCHD in the UK between 2013–2018 for the purpose of informing or supplementing participant data. We extracted trial characteristics, the registry accessed, and the way the RCHD was used. RESULTS: The 15 feasibility RCTs were conducted in a variety of disease areas, and were generally small (median sample size 100, range 41–4061) and individually randomised (60%, 9/15). The primary trial outcome was predominantly administrative (non-clinical) (80%, 12/15) such as feasibility of patient recruitment. They were more likely to recruit from secondary care (67%, 10/15) settings than primary (33%, 5/15). NHS Digital was the most commonly accessed registry (33% (5/15)) with SAIL databank (20% (3/15)), electronic Data Research and Innovation Service (eDRIS) and Paediatric Intensive Care Audit Network (PICANET) (each 13% 2/15) also being accessed. Where the information was clear, the trials used RCHD for data collection during the trial (47%, 7/15), follow-up after the trial (27%, 4/15) and recruitment (13%, 2/15). CONCLUSIONS: Between 2013 and 2018, 15 feasibility trials successfully accessed UK RCHD. Feasibility trials would benefit, as with other trials, from guidance on reporting the use of RCHD in protocols and publications. date: 2021-08-16 date_type: published publisher: F1000 Research Ltd official_url: https://doi.org/10.12688/f1000research.52486.1 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1882973 doi: 10.12688/f1000research.52486.1 lyricists_name: Carpenter, James lyricists_name: Love, Sharon lyricists_name: Murray, Macey lyricists_name: Sydes, Matthew lyricists_name: Yorke-Edwards, Victoria lyricists_id: JCARP26 lyricists_id: SLOVE68 lyricists_id: MMURR38 lyricists_id: MRSYD21 lyricists_id: VYORK86 actors_name: Zahnhausen-Stuber, Petra actors_id: PMZAH20 actors_role: owner full_text_status: public publication: F1000Research volume: 10 article_number: 815 citation: Mirza, A; Yorke-Edwards, V; Lensen, S; Murray, ML; Diaz-Montana, C; Carpenter, J; Sydes, MR; Mirza, A; Yorke-Edwards, V; Lensen, S; Murray, ML; Diaz-Montana, C; Carpenter, J; Sydes, MR; Love, SB; - view fewer <#> (2021) Why are feasibility studies accessing routinely collected health data? A systematic review. F1000Research , 10 , Article 815. 10.12688/f1000research.52486.1 <https://doi.org/10.12688/f1000research.52486.1>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10133294/3/Love_c6801be5-2549-4d85-a905-b19e56654c8b_52486_-_sharon_love.pdf