%X Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ)-induced phosphorylation of the axon-stabilizing tau protein, which causes neurodegeneration. Here, Morshed et al. show that deregulated phosphorylation in AD also affects other proteins and cell types in the brain, suggesting that the tau-centric view on Aβ toxicity should be revised.
%J Nature Aging
%A G Brinkmalm
%A H Zetterberg
%O This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
%I Springer Science and Business Media LLC
%L discovery10131989
%V 1
%D 2021
%N 6
%T The phosphorylation cascade hypothesis of Alzheimer’s disease
%P 498-499