%X Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ)-induced phosphorylation of the axon-stabilizing tau protein, which causes neurodegeneration. Here, Morshed et al. show that deregulated phosphorylation in AD also affects other proteins and cell types in the brain, suggesting that the tau-centric view on Aβ toxicity should be revised. %J Nature Aging %A G Brinkmalm %A H Zetterberg %O This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. %I Springer Science and Business Media LLC %L discovery10131989 %V 1 %D 2021 %N 6 %T The phosphorylation cascade hypothesis of Alzheimer’s disease %P 498-499