@article{discovery10131989, note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.}, publisher = {Springer Science and Business Media LLC}, month = {June}, pages = {498--499}, journal = {Nature Aging}, volume = {1}, year = {2021}, title = {The phosphorylation cascade hypothesis of Alzheimer's disease}, number = {6}, abstract = {Alzheimer's disease (AD) is characterized by amyloid-{\ensuremath{\beta}} (A{\ensuremath{\beta}})-induced phosphorylation of the axon-stabilizing tau protein, which causes neurodegeneration. Here, Morshed et al. show that deregulated phosphorylation in AD also affects other proteins and cell types in the brain, suggesting that the tau-centric view on A{\ensuremath{\beta}} toxicity should be revised.}, url = {http://dx.doi.org/10.1038/s43587-021-00077-9}, author = {Brinkmalm, G and Zetterberg, H} }