<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10131513> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/dc/terms/title> "Molecular subtype-specific efficacy of anti-EGFR therapy in colorectal cancer is dependent on the chemotherapy backbone"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/ontology/bibo/abstract> "BACKGROUND: Patient selection for addition of anti-EGFR therapy to chemotherapy for patients with RAS and BRAF wildtype metastatic colorectal cancer can still be optimised. Here we investigate the effect of anti-EGFR therapy on survival in different consensus molecular subtypes (CMSs) and stratified by primary tumour location. METHODS: Retrospective analyses, using the immunohistochemistry-based CMS classifier, were performed in the COIN (first-line oxaliplatin backbone with or without cetuximab) and PICCOLO trial (second-line irinotecan with or without panitumumab). Tumour tissue was available for 323 patients (20%) and 349 (41%), respectively. RESULTS: When using an irinotecan backbone, anti-EGFR therapy is effective in both CMS2/3 and CMS4 in left-sided primary tumours (progression-free survival (PFS): HR 0.44, 95% CI 0.26-0.75, P = 0.003 and HR 0.12, 95% CI 0.04-0.36, P < 0.001, respectively) and in CMS4 right-sided tumours (PFS HR 0.17, 95% CI 0.04-0.71, P = 0.02). Efficacy using an oxaliplatin backbone was restricted to left-sided CMS2/3 tumours (HR 0.57, 95% CI 0.36-0.96, P = 0.034). CONCLUSIONS: The subtype-specific efficacy of anti-EGFR therapy is dependent on the chemotherapy backbone. This may provide the possibility of subtype-specific treatment strategies for a more optimal use of anti-EGFR therapy."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/dc/terms/date> "2021-07-12" .
<https://discovery.ucl.ac.uk/id/document/1344095> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/publication/ext-d62316368c8aec2f6f582abfb306763b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-d62316368c8aec2f6f582abfb306763b> <http://xmlns.com/foaf/0.1/name> "British Journal of Cancer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-d62316368c8aec2f6f582abfb306763b> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/forthcoming> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b8d586ed335232924c83c4402c4d669d> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131513#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10131513#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-b8d586ed335232924c83c4402c4d669d> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-829d65515cab06c0fb3499cc16356141> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131513#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10131513#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-829d65515cab06c0fb3499cc16356141> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-88ee225f6344932fd98229f630103d62> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131513#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10131513#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-88ee225f6344932fd98229f630103d62> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-64dfe923e5ba50eb801d88060531fb42> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131513#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10131513#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-64dfe923e5ba50eb801d88060531fb42> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-dcabcccfa306879ba05455507f486fd8> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131513#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10131513#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-dcabcccfa306879ba05455507f486fd8> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b90969f1c6362cfb0a4af1d2a60c7d84> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131513#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10131513#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-b90969f1c6362cfb0a4af1d2a60c7d84> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ba760936ec23a258f09ba60ded20492a> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131513#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10131513#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-ba760936ec23a258f09ba60ded20492a> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d7e8a48eff0cfc1c00a8977f65368157> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131513#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10131513#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-d7e8a48eff0cfc1c00a8977f65368157> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-33209163c19b3cd5c74f77f54906be69> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131513#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10131513#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-33209163c19b3cd5c74f77f54906be69> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d6505cc5a6c60a968525fc9f0d2fbc74> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131513#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10131513#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-d6505cc5a6c60a968525fc9f0d2fbc74> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c375b81616b5f5cc5f1662aced25f7c1> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131513#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10131513#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-c375b81616b5f5cc5f1662aced25f7c1> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7cf2bf46dfad6964f6f0d409980bf38f> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131513#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10131513#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-7cf2bf46dfad6964f6f0d409980bf38f> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2b0221bfaf6342d5eb5f8f7680b288f3> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131513#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10131513#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-2b0221bfaf6342d5eb5f8f7680b288f3> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0621eac801a8ec1ce2f392109a0a39a1> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131513#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10131513#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-0621eac801a8ec1ce2f392109a0a39a1> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9e19b03b0e45f8532a60e32faefefb45> .
<https://discovery.ucl.ac.uk/id/eprint/10131513> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131513#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10131513#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-9e19b03b0e45f8532a60e32faefefb45> .
<https://discovery.ucl.ac.uk/id/person/ext-c375b81616b5f5cc5f1662aced25f7c1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c375b81616b5f5cc5f1662aced25f7c1> <http://xmlns.com/foaf/0.1/givenName> "P"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c375b81616b5f5cc5f1662aced25f7c1> <http://xmlns.com/foaf/0.1/familyName> "Quirke"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c375b81616b5f5cc5f1662aced25f7c1> <http://xmlns.com/foaf/0.1/name> "P Quirke"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7cf2bf46dfad6964f6f0d409980bf38f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7cf2bf46dfad6964f6f0d409980bf38f> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7cf2bf46dfad6964f6f0d409980bf38f> <http://xmlns.com/foaf/0.1/familyName> "Adams"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7cf2bf46dfad6964f6f0d409980bf38f> <http://xmlns.com/foaf/0.1/name> "R Adams"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9e19b03b0e45f8532a60e32faefefb45> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9e19b03b0e45f8532a60e32faefefb45> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9e19b03b0e45f8532a60e32faefefb45> <http://xmlns.com/foaf/0.1/familyName> "Vermeulen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9e19b03b0e45f8532a60e32faefefb45> <http://xmlns.com/foaf/0.1/name> "L Vermeulen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-829d65515cab06c0fb3499cc16356141> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-829d65515cab06c0fb3499cc16356141> <http://xmlns.com/foaf/0.1/givenName> "DW"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-829d65515cab06c0fb3499cc16356141> <http://xmlns.com/foaf/0.1/familyName> "Sommeijer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-829d65515cab06c0fb3499cc16356141> <http://xmlns.com/foaf/0.1/name> "DW Sommeijer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d7e8a48eff0cfc1c00a8977f65368157> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d7e8a48eff0cfc1c00a8977f65368157> <http://xmlns.com/foaf/0.1/givenName> "T"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d7e8a48eff0cfc1c00a8977f65368157> <http://xmlns.com/foaf/0.1/familyName> "Maughan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d7e8a48eff0cfc1c00a8977f65368157> <http://xmlns.com/foaf/0.1/name> "T Maughan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-33209163c19b3cd5c74f77f54906be69> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-33209163c19b3cd5c74f77f54906be69> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-33209163c19b3cd5c74f77f54906be69> <http://xmlns.com/foaf/0.1/familyName> "Seligmann"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-33209163c19b3cd5c74f77f54906be69> <http://xmlns.com/foaf/0.1/name> "J Seligmann"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2b0221bfaf6342d5eb5f8f7680b288f3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2b0221bfaf6342d5eb5f8f7680b288f3> <http://xmlns.com/foaf/0.1/givenName> "SD"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2b0221bfaf6342d5eb5f8f7680b288f3> <http://xmlns.com/foaf/0.1/familyName> "Richman"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2b0221bfaf6342d5eb5f8f7680b288f3> <http://xmlns.com/foaf/0.1/name> "SD Richman"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b8d586ed335232924c83c4402c4d669d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b8d586ed335232924c83c4402c4d669d> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b8d586ed335232924c83c4402c4d669d> <http://xmlns.com/foaf/0.1/familyName> "Ten Hoorn"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b8d586ed335232924c83c4402c4d669d> <http://xmlns.com/foaf/0.1/name> "S Ten Hoorn"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b90969f1c6362cfb0a4af1d2a60c7d84> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b90969f1c6362cfb0a4af1d2a60c7d84> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b90969f1c6362cfb0a4af1d2a60c7d84> <http://xmlns.com/foaf/0.1/familyName> "Trinh"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b90969f1c6362cfb0a4af1d2a60c7d84> <http://xmlns.com/foaf/0.1/name> "A Trinh"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dcabcccfa306879ba05455507f486fd8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-dcabcccfa306879ba05455507f486fd8> <http://xmlns.com/foaf/0.1/givenName> "TR"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dcabcccfa306879ba05455507f486fd8> <http://xmlns.com/foaf/0.1/familyName> "de Back"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dcabcccfa306879ba05455507f486fd8> <http://xmlns.com/foaf/0.1/name> "TR de Back"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-88ee225f6344932fd98229f630103d62> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-88ee225f6344932fd98229f630103d62> <http://xmlns.com/foaf/0.1/givenName> "F"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-88ee225f6344932fd98229f630103d62> <http://xmlns.com/foaf/0.1/familyName> "Elliott"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-88ee225f6344932fd98229f630103d62> <http://xmlns.com/foaf/0.1/name> "F Elliott"^^<http://www.w3.org/2001/XMLSchema#string> .
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