<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10131324> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/dc/terms/title> "KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/ontology/bibo/abstract> "Klotho-VS heterozygosity (KL-VShet) is associated with reduced risk of Alzheimer's disease (AD). However, whether KL-VShet is associated with lower levels of pathologic tau, i.e., the key AD pathology driving neurodegeneration and cognitive decline, is unknown. Here, we assessed the interaction between KL-VShet and levels of beta-amyloid, a key driver of tau pathology, on the levels of PET-assessed neurofibrillary tau in 551 controls and patients across the AD continuum. KL-VShet showed lower cross-sectional and longitudinal increase in tau-PET per unit increase in amyloid-PET when compared to that of non-carriers. This association of KL-VShet on tau-PET was stronger in Klotho mRNA-expressing brain regions mapped onto a gene expression atlas. KL-VShet was related to better memory functions in amyloid-positive participants and this association was mediated by lower tau-PET. Amyloid-PET levels did not differ between KL-VShet carriers versus non-carriers. Together, our findings provide evidence to suggest a protective role of KL-VShet against amyloid-related tau pathology and tau-related memory impairments in elderly humans at risk of AD dementia."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/dc/terms/date> "2021" . <https://discovery.ucl.ac.uk/id/document/1342498> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/ontology/bibo/volume> "12" . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/ontology/bibo/issue> "1" . <https://discovery.ucl.ac.uk/id/publication/ext-93ad60708ded9f1ac36bc6a921129f1f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-93ad60708ded9f1ac36bc6a921129f1f> <http://xmlns.com/foaf/0.1/name> "Nature Communications"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-93ad60708ded9f1ac36bc6a921129f1f> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e7fae9e8847a9e9919a20bdaf8a003bd> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131324#authors> . <https://discovery.ucl.ac.uk/id/eprint/10131324#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-e7fae9e8847a9e9919a20bdaf8a003bd> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4dd6ecbf9a7efe83fc18566fa955c93a> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131324#authors> . <https://discovery.ucl.ac.uk/id/eprint/10131324#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-4dd6ecbf9a7efe83fc18566fa955c93a> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0270fd6ee0699eadf6ed8b7931a026e4> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131324#authors> . <https://discovery.ucl.ac.uk/id/eprint/10131324#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-0270fd6ee0699eadf6ed8b7931a026e4> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-79a3938dd0b1aa4c4f96cabcfb9466d8> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131324#authors> . <https://discovery.ucl.ac.uk/id/eprint/10131324#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-79a3938dd0b1aa4c4f96cabcfb9466d8> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-89f7baed21e144a7150dfdccbed78750> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131324#authors> . <https://discovery.ucl.ac.uk/id/eprint/10131324#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-89f7baed21e144a7150dfdccbed78750> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c3de4e4916a51efc126838d05e2f526f> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131324#authors> . <https://discovery.ucl.ac.uk/id/eprint/10131324#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-c3de4e4916a51efc126838d05e2f526f> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-74bb12a1268475408a8611cb118b570e> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131324#authors> . <https://discovery.ucl.ac.uk/id/eprint/10131324#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-74bb12a1268475408a8611cb118b570e> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-79703daf01b2163f68d69839e8514882> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10131324#authors> . <https://discovery.ucl.ac.uk/id/eprint/10131324#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-79703daf01b2163f68d69839e8514882> . <https://discovery.ucl.ac.uk/id/person/ext-74bb12a1268475408a8611cb118b570e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-74bb12a1268475408a8611cb118b570e> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-74bb12a1268475408a8611cb118b570e> <http://xmlns.com/foaf/0.1/familyName> "Malik"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-74bb12a1268475408a8611cb118b570e> <http://xmlns.com/foaf/0.1/name> "R Malik"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-79a3938dd0b1aa4c4f96cabcfb9466d8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-79a3938dd0b1aa4c4f96cabcfb9466d8> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-79a3938dd0b1aa4c4f96cabcfb9466d8> <http://xmlns.com/foaf/0.1/familyName> "Dichgans"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-79a3938dd0b1aa4c4f96cabcfb9466d8> <http://xmlns.com/foaf/0.1/name> "M Dichgans"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0270fd6ee0699eadf6ed8b7931a026e4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-0270fd6ee0699eadf6ed8b7931a026e4> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0270fd6ee0699eadf6ed8b7931a026e4> <http://xmlns.com/foaf/0.1/familyName> "Rubinski"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0270fd6ee0699eadf6ed8b7931a026e4> <http://xmlns.com/foaf/0.1/name> "A Rubinski"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-89f7baed21e144a7150dfdccbed78750> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-89f7baed21e144a7150dfdccbed78750> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-89f7baed21e144a7150dfdccbed78750> <http://xmlns.com/foaf/0.1/familyName> "Brendel"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-89f7baed21e144a7150dfdccbed78750> <http://xmlns.com/foaf/0.1/name> "M Brendel"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-79703daf01b2163f68d69839e8514882> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-79703daf01b2163f68d69839e8514882> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-79703daf01b2163f68d69839e8514882> <http://xmlns.com/foaf/0.1/familyName> "Ewers"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-79703daf01b2163f68d69839e8514882> <http://xmlns.com/foaf/0.1/name> "M Ewers"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4dd6ecbf9a7efe83fc18566fa955c93a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-4dd6ecbf9a7efe83fc18566fa955c93a> <http://xmlns.com/foaf/0.1/givenName> "N"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4dd6ecbf9a7efe83fc18566fa955c93a> <http://xmlns.com/foaf/0.1/familyName> "Franzmeier"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4dd6ecbf9a7efe83fc18566fa955c93a> <http://xmlns.com/foaf/0.1/name> "N Franzmeier"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e7fae9e8847a9e9919a20bdaf8a003bd> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-e7fae9e8847a9e9919a20bdaf8a003bd> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e7fae9e8847a9e9919a20bdaf8a003bd> <http://xmlns.com/foaf/0.1/familyName> "Neitzel"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e7fae9e8847a9e9919a20bdaf8a003bd> <http://xmlns.com/foaf/0.1/name> "J Neitzel"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c3de4e4916a51efc126838d05e2f526f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-c3de4e4916a51efc126838d05e2f526f> <http://xmlns.com/foaf/0.1/givenName> "."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c3de4e4916a51efc126838d05e2f526f> <http://xmlns.com/foaf/0.1/familyName> "Alzheimer’s Disease Neuroimaging Initiative (ADNI)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c3de4e4916a51efc126838d05e2f526f> <http://xmlns.com/foaf/0.1/name> ". Alzheimer’s Disease Neuroimaging Initiative (ADNI)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1342498> . <https://discovery.ucl.ac.uk/id/document/1342498> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> . <https://discovery.ucl.ac.uk/id/document/1342498> <http://www.w3.org/2000/01/rdf-schema#label> "KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease (Text)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://purl.org/dc/elements/1.1/hasVersion> <https://discovery.ucl.ac.uk/id/document/1342498> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://eprints.org/ontology/hasPublished> <https://discovery.ucl.ac.uk/id/document/1342498> . <https://discovery.ucl.ac.uk/id/document/1342498> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10131324/1/s41467-021-23755-z.pdf> . <https://discovery.ucl.ac.uk/id/document/1342498> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10131324/1/s41467-021-23755-z.pdf> . <https://discovery.ucl.ac.uk/id/eprint/10131324/1/s41467-021-23755-z.pdf> <http://www.w3.org/2000/01/rdf-schema#label> "s41467-021-23755-z.pdf"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1342500> . <https://discovery.ucl.ac.uk/id/document/1342500> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> . <https://discovery.ucl.ac.uk/id/document/1342500> <http://www.w3.org/2000/01/rdf-schema#label> "KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease (Other)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/document/1342500> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1342498> . <https://discovery.ucl.ac.uk/id/document/1342500> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1342498> . <https://discovery.ucl.ac.uk/id/document/1342500> <http://eprints.org/relation/ispreviewThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/1342498> . <https://discovery.ucl.ac.uk/id/document/1342500> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10131324/3/preview.jpg> . <https://discovery.ucl.ac.uk/id/document/1342500> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10131324/3/preview.jpg> . <https://discovery.ucl.ac.uk/id/eprint/10131324/3/preview.jpg> <http://www.w3.org/2000/01/rdf-schema#label> "preview.jpg"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10131324> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1342501> . <https://discovery.ucl.ac.uk/id/document/1342501> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> . <https://discovery.ucl.ac.uk/id/document/1342501> <http://www.w3.org/2000/01/rdf-schema#label> "KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease (Other)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/document/1342501> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1342498> . <https://discovery.ucl.ac.uk/id/document/1342501> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1342498> . <https://discovery.ucl.ac.uk/id/document/1342501> <http://eprints.org/relation/ismediumThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/1342498> . <https://discovery.ucl.ac.uk/id/document/1342501> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10131324/4/medium.jpg> . <https://discovery.ucl.ac.uk/id/document/1342501> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10131324/4/medium.jpg> . <https://discovery.ucl.ac.uk/id/eprint/10131324/4/medium.jpg> <http://www.w3.org/2000/01/rdf-schema#label> "medium.jpg"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10131324> 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