<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10130842> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/dc/terms/title> "Intraoperative anti-A/B immunoadsorption is associated with significantly reduced blood product utilization with similar outcomes in pediatric ABO-incompatible heart transplantation"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/ontology/bibo/abstract> "BACKGROUND: Intraoperative anti-A/B immunoadsorption (ABO-IA) was recently introduced for ABO-incompatible heart transplantation. Here we report the first case series of patients transplanted with ABO-IA, and compare outcomes with those undergoing plasma exchange facilitated ABO-incompatible heart transplantation (ABO-PE). METHODS: Data were retrospectively analysed on all ABO-incompatible heart transplants undertaken at a single centre between January 1, 2000 and June 1, 2020. Data included all routine laboratory tests, demographics and pre-operative characteristics, intraoperative details and post-operative outcomes. Primary outcome measures were volume of blood product transfusions, maximum post-transplant isohaemagglutinin titres, occurrence of rejection and graft survival. Secondary outcome measures were length of intensive care and hospital stay. Demographic and survival data were also obtained for ABO-compatible transplants during the same time period for comparison. RESULTS: Thirty-seven patients underwent ABO-incompatible heart transplantation, with 27 (73%) using ABO-PE and 10 (27%) using ABO-IA. ABO-IA patients were significantly older than ABO-PE patients (p < 0.001) and the total volume of blood products transfused during the hospital admission was significantly lower (164 [126-212] ml/kg vs 323 [268-379] ml/kg, p < 0.001). No significant differences were noted between methods in either pre or post-transplant maximum isohaemagglutinin titres, incidence of rejection, length of intensive care or total hospital stay. Survival comparison showed no significant difference between antibody reduction methods, or indeed ABO-compatible transplants (p = 0.6). CONCLUSIONS: This novel technique appears to allow a significantly older population than typical to undergo ABO-incompatible heart transplantation, as well as significantly reducing blood product utilization. Furthermore, intraoperative anti-A/B immunoadsorption does not demonstrate increased early post-transplant isohaemagglutinin accumulation or rates of rejection compared to ABO-PE. Early survival is equivalent between ABO-IA, ABO-PE and ABO-compatible heart transplantation."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/dc/terms/date> "2021-05-29" . <https://discovery.ucl.ac.uk/id/document/1338778> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/publication/ext-1818b12c3c2c9cc434fc3067cd931fd6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-1818b12c3c2c9cc434fc3067cd931fd6> <http://xmlns.com/foaf/0.1/name> "The Journal of Heart and Lung Transplantation"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-1818b12c3c2c9cc434fc3067cd931fd6> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/forthcoming> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7e698f7382534967bca8d372da64a7fb> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> . <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-7e698f7382534967bca8d372da64a7fb> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4013c61e7be6113e28ca3255d012a14b> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> . <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-4013c61e7be6113e28ca3255d012a14b> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0a7b321d8ce80d39e61255b11af43a2e> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> . <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-0a7b321d8ce80d39e61255b11af43a2e> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-38b76246ea1a091cd4fd7f1f96d1be8f> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> . <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-38b76246ea1a091cd4fd7f1f96d1be8f> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a805f8c520f3a4ca0e4a17545c2bed2c> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> . <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-a805f8c520f3a4ca0e4a17545c2bed2c> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a9c1313a08d98fcbfcfcdd2523e449b3> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> . <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-a9c1313a08d98fcbfcfcdd2523e449b3> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1b3982fca49bef13bd2df714a06e0805> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> . <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-1b3982fca49bef13bd2df714a06e0805> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c85c6d4d9c7f40a333681128ce7ebf42> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> . <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-c85c6d4d9c7f40a333681128ce7ebf42> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a5031a494a3ba40cc2f378698b457d47> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> . <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-a5031a494a3ba40cc2f378698b457d47> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5e8150d34c476ba8f0859dd04a8c551d> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> . <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-5e8150d34c476ba8f0859dd04a8c551d> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3f4dc89f09510584025ca26d1bd4921e> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> . <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-3f4dc89f09510584025ca26d1bd4921e> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9603b7e9e13809bc1f24eb496cbc33b3> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> . <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-9603b7e9e13809bc1f24eb496cbc33b3> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b4614adc8b6aa23e5daf824ba0b09d41> . <https://discovery.ucl.ac.uk/id/eprint/10130842> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> . <https://discovery.ucl.ac.uk/id/eprint/10130842#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-b4614adc8b6aa23e5daf824ba0b09d41> . <https://discovery.ucl.ac.uk/id/person/ext-9603b7e9e13809bc1f24eb496cbc33b3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-9603b7e9e13809bc1f24eb496cbc33b3> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9603b7e9e13809bc1f24eb496cbc33b3> <http://xmlns.com/foaf/0.1/familyName> "Burch"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9603b7e9e13809bc1f24eb496cbc33b3> <http://xmlns.com/foaf/0.1/name> "M Burch"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c85c6d4d9c7f40a333681128ce7ebf42> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-c85c6d4d9c7f40a333681128ce7ebf42> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c85c6d4d9c7f40a333681128ce7ebf42> <http://xmlns.com/foaf/0.1/familyName> "Shaw"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c85c6d4d9c7f40a333681128ce7ebf42> <http://xmlns.com/foaf/0.1/name> "M Shaw"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5e8150d34c476ba8f0859dd04a8c551d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-5e8150d34c476ba8f0859dd04a8c551d> <http://xmlns.com/foaf/0.1/givenName> "V"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5e8150d34c476ba8f0859dd04a8c551d> <http://xmlns.com/foaf/0.1/familyName> "Muthurangu"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5e8150d34c476ba8f0859dd04a8c551d> <http://xmlns.com/foaf/0.1/name> "V Muthurangu"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1b3982fca49bef13bd2df714a06e0805> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-1b3982fca49bef13bd2df714a06e0805> <http://xmlns.com/foaf/0.1/givenName> "N"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1b3982fca49bef13bd2df714a06e0805> <http://xmlns.com/foaf/0.1/familyName> "Cross"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1b3982fca49bef13bd2df714a06e0805> <http://xmlns.com/foaf/0.1/name> "N Cross"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-38b76246ea1a091cd4fd7f1f96d1be8f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-38b76246ea1a091cd4fd7f1f96d1be8f> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-38b76246ea1a091cd4fd7f1f96d1be8f> <http://xmlns.com/foaf/0.1/familyName> "Robertson"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-38b76246ea1a091cd4fd7f1f96d1be8f> <http://xmlns.com/foaf/0.1/name> "A Robertson"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a5031a494a3ba40cc2f378698b457d47> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-a5031a494a3ba40cc2f378698b457d47> <http://xmlns.com/foaf/0.1/givenName> "V"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a5031a494a3ba40cc2f378698b457d47> <http://xmlns.com/foaf/0.1/familyName> "Tsang"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a5031a494a3ba40cc2f378698b457d47> <http://xmlns.com/foaf/0.1/name> "V Tsang"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0a7b321d8ce80d39e61255b11af43a2e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-0a7b321d8ce80d39e61255b11af43a2e> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0a7b321d8ce80d39e61255b11af43a2e> <http://xmlns.com/foaf/0.1/familyName> "Crook"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0a7b321d8ce80d39e61255b11af43a2e> <http://xmlns.com/foaf/0.1/name> "R Crook"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a9c1313a08d98fcbfcfcdd2523e449b3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-a9c1313a08d98fcbfcfcdd2523e449b3> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a9c1313a08d98fcbfcfcdd2523e449b3> <http://xmlns.com/foaf/0.1/familyName> "Richardson"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a9c1313a08d98fcbfcfcdd2523e449b3> <http://xmlns.com/foaf/0.1/name> "R Richardson"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b4614adc8b6aa23e5daf824ba0b09d41> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-b4614adc8b6aa23e5daf824ba0b09d41> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b4614adc8b6aa23e5daf824ba0b09d41> <http://xmlns.com/foaf/0.1/familyName> "Fenton"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b4614adc8b6aa23e5daf824ba0b09d41> <http://xmlns.com/foaf/0.1/name> "M Fenton"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7e698f7382534967bca8d372da64a7fb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-7e698f7382534967bca8d372da64a7fb> <http://xmlns.com/foaf/0.1/givenName> 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