eprintid: 10130812
rev_number: 16
eprint_status: archive
userid: 608
dir: disk0/10/13/08/12
datestamp: 2021-07-07 10:50:31
lastmod: 2021-12-20 23:36:01
status_changed: 2021-07-07 10:50:31
type: article
metadata_visibility: show
creators_name: Roche, R
creators_name: Simmons, R
creators_name: Logan, L
creators_name: Ledesma, J
creators_name: Sabin, C
creators_name: Ijaz, S
creators_name: Mandal, S
title: Prevalence of hepatitis B immunity and infection in home self-sampling HIV service users
ispublished: inpress
divisions: UCL
divisions: B02
divisions: D01
divisions: G16
keywords: communicable diseases, epidemiology, hepatitis B, serology, sexual health
note: © Author(s) (or their employer[s]) 2021. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license (http://creativecommons.org/licenses/by-nc/4.0/).
abstract: OBJECTIVES: Although hepatitis B virus (HBV) vaccination for high-risk groups including gay, bisexual and other men who have sex with men (MSM) is recommended in the UK, data on HBV immunisation coverage are limited. This study aimed to understand the prevalence of HBV infection, susceptibility and immunity due to immunisation among a high-risk population of MSM and heterosexuals who are less likely to attend sexual health services. METHODS: Residual HIV-negative serology samples archived from a national HIV self-sampling service in 2016 were tested for HBV markers using an unlinked anonymous approach. Prevalence of HBV infection, evidence of immunisation and susceptibility were calculated and stratified by individuals' characteristics. Multinomial logistic regression was used to estimate relative risk ratios (RRRs) associated with covariates. RESULTS: Of 2172 samples tested, 1497 (68.9%) were from MSM and 657 (30.2%) were from heterosexuals. Susceptibility to HBV infection was 66.1% among MSM and 77.0% among heterosexuals. Only 29.9% of MSM and 17.4% of heterosexuals had serological evidence of immunisation. Current infection was 1.1% in heterosexuals and 0.2% in MSM. Adjusted analysis showed evidence of immunisation was lower among heterosexuals (RRR 0.66, 95% CI 0.50 to 0.86) and those with no previous HIV test (RRR 0.41, 95% CI 0.31 to 0.54), and higher in those of other white or other ethnicity. CONCLUSIONS: Among MSM and heterosexual users of a self-sampling HIV service, evidence of immunisation to HBV infection was low and susceptibility to infection was comparatively high, suggesting suboptimal delivery of HBV immunisation in sexual health services.
date: 2021-06-30
date_type: published
official_url: http://dx.doi.org/10.1136/sextrans-2021-055071
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1874926
doi: 10.1136/sextrans-2021-055071
pii: sextrans-2021-055071
lyricists_name: Sabin, Caroline
lyricists_id: CASAB15
actors_name: Barczynska, Patrycja
actors_id: PBARC91
actors_role: owner
full_text_status: public
publication: Sexually Transmitted Infections
event_location: England
citation:        Roche, R;    Simmons, R;    Logan, L;    Ledesma, J;    Sabin, C;    Ijaz, S;    Mandal, S;      (2021)    Prevalence of hepatitis B immunity and infection in home self-sampling HIV service users.                   Sexually Transmitted Infections        10.1136/sextrans-2021-055071 <https://doi.org/10.1136/sextrans-2021-055071>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10130812/1/Sabin_sextrans-2021-055071.full.pdf