eprintid: 10130481
rev_number: 12
eprint_status: archive
userid: 608
dir: disk0/10/13/04/81
datestamp: 2021-07-01 12:59:29
lastmod: 2021-07-01 12:59:29
status_changed: 2021-07-01 12:59:29
type: proceedings_section
metadata_visibility: show
creators_name: Pifferi, A
creators_name: Dalla Mora, A
creators_name: Di Sieno, L
creators_name: Ferocino, E
creators_name: Tosi, A
creators_name: Conca, E
creators_name: Sesta, V
creators_name: Giudice, A
creators_name: Ruggeri, A
creators_name: Tisa, S
creators_name: Flocke, A
creators_name: Rosinski, B
creators_name: Dinten, JM
creators_name: Perriollat, M
creators_name: Fraschini, C
creators_name: Sportouche, H
creators_name: Arridge, S
creators_name: Di Sciacca, G
creators_name: Farina, A
creators_name: Panizza, P
creators_name: Venturini, E
creators_name: Gordebeke, P
creators_name: Zolda, P
creators_name: Taroni, P
title: SOLUS: An innovative multimodal imaging system to improve breast cancer diagnosis through diffuse optics and ultrasounds
ispublished: pub
divisions: UCL
divisions: A01
divisions: B04
divisions: C05
divisions: F48
note: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: To improve non-invasively the specificity in the diagnosis of breast cancer after a positive screening mammography or doubt/suspicious ultrasound examination, the SOLUS project developed a multimodal imaging system that combines: B-mode ultrasound (US) scans (to assess morphology), Color Doppler (to visualize vascularization), shear-wave elastography (to measure stiffness), and time domain multi-wavelength diffuse optical tomography (to estimate tissue composition in terms of oxy- and deoxy-hemoglobin, lipid, water, and collagen concentrations). The multimodal probe arranges 8 innovative photonic modules (optodes) around the US transducer, providing capability for optical tomographic reconstruction. For more accurate estimate of lesion composition, US-assessed morphological priors can be used to guide the optical reconstructions. Each optode comprises: i) 8 picosecond pulsed laser diodes with different wavelengths, covering a wide spectral range (635-1064 nm) for good probing of the different tissue constituents; ii) a large-area (variable, up to 8.6 mm2) fast-gated digital Silicon Photomultiplier; iii) the acquisition electronics to record the distribution of time-of-flight of the re-emitted photons. The optode is the basic element of the optical part of the system, but is also a stand-alone, ultra-compact (about 4 cm3) device for time domain multi-wavelength diffuse optics, with potential application in various fields.
date: 2021-01-01
date_type: published
publisher: SPIE
official_url: https://doi.org/10.1117/12.2576778
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1872398
doi: 10.1117/12.2576778
isbn_13: 9781510641136
lyricists_name: Arridge, Simon
lyricists_id: SRARR14
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
volume: 11639
place_of_pub: Online Only
pagerange: 116390C
event_title: SPIE BiOS
issn: 1605-7422
book_title: Proceedings of Optical Tomography and Spectroscopy of Tissue XIV
citation:        Pifferi, A;    Dalla Mora, A;    Di Sieno, L;    Ferocino, E;    Tosi, A;    Conca, E;    Sesta, V;                                                                     ... Taroni, P; + view all <#>        Pifferi, A;  Dalla Mora, A;  Di Sieno, L;  Ferocino, E;  Tosi, A;  Conca, E;  Sesta, V;  Giudice, A;  Ruggeri, A;  Tisa, S;  Flocke, A;  Rosinski, B;  Dinten, JM;  Perriollat, M;  Fraschini, C;  Sportouche, H;  Arridge, S;  Di Sciacca, G;  Farina, A;  Panizza, P;  Venturini, E;  Gordebeke, P;  Zolda, P;  Taroni, P;   - view fewer <#>    (2021)    SOLUS: An innovative multimodal imaging system to improve breast cancer diagnosis through diffuse optics and ultrasounds.                     In:  Proceedings of Optical Tomography and Spectroscopy of Tissue XIV.  (pp. 116390C).  SPIE: Online Only.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10130481/1/116390C.pdf