TY  - GEN
ID  - discovery10130481
N2  - To improve non-invasively the specificity in the diagnosis of breast cancer after a positive screening mammography or doubt/suspicious ultrasound examination, the SOLUS project developed a multimodal imaging system that combines: B-mode ultrasound (US) scans (to assess morphology), Color Doppler (to visualize vascularization), shear-wave elastography (to measure stiffness), and time domain multi-wavelength diffuse optical tomography (to estimate tissue composition in terms of oxy- and deoxy-hemoglobin, lipid, water, and collagen concentrations). The multimodal probe arranges 8 innovative photonic modules (optodes) around the US transducer, providing capability for optical tomographic reconstruction. For more accurate estimate of lesion composition, US-assessed morphological priors can be used to guide the optical reconstructions. Each optode comprises: i) 8 picosecond pulsed laser diodes with different wavelengths, covering a wide spectral range (635-1064 nm) for good probing of the different tissue constituents; ii) a large-area (variable, up to 8.6 mm2) fast-gated digital Silicon Photomultiplier; iii) the acquisition electronics to record the distribution of time-of-flight of the re-emitted photons. The optode is the basic element of the optical part of the system, but is also a stand-alone, ultra-compact (about 4 cm3) device for time domain multi-wavelength diffuse optics, with potential application in various fields.
SN  - 1605-7422
UR  - https://doi.org/10.1117/12.2576778
PB  - SPIE
CY  - Online Only
A1  - Pifferi, A
A1  - Dalla Mora, A
A1  - Di Sieno, L
A1  - Ferocino, E
A1  - Tosi, A
A1  - Conca, E
A1  - Sesta, V
A1  - Giudice, A
A1  - Ruggeri, A
A1  - Tisa, S
A1  - Flocke, A
A1  - Rosinski, B
A1  - Dinten, JM
A1  - Perriollat, M
A1  - Fraschini, C
A1  - Sportouche, H
A1  - Arridge, S
A1  - Di Sciacca, G
A1  - Farina, A
A1  - Panizza, P
A1  - Venturini, E
A1  - Gordebeke, P
A1  - Zolda, P
A1  - Taroni, P
TI  - SOLUS: An innovative multimodal imaging system to improve breast cancer diagnosis through diffuse optics and ultrasounds
AV  - public
Y1  - 2021/01/01/
N1  - This version is the version of record. For information on re-use, please refer to the publisher?s terms and conditions.
ER  -