<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10130389> .
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<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://purl.org/dc/terms/title> "Effects of pre-analytical procedures on blood biomarkers for Alzheimer's pathophysiology, glial activation, and neurodegeneration."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://purl.org/ontology/bibo/abstract> "Introduction: We tested how tube types (ethylenediaminetetraacetic acid [EDTA], serum, lithium heparin [LiHep], and citrate) and freeze-thaw cycles affect levels of blood biomarkers for Alzheimer's disease (AD) pathophysiology, glial activation, and neuronal injury. Methods: Amyloid beta (Aβ)42, Aβ40, phosphorylated tau181 (p-tau181), glial fibrillary acidic protein, total tau (t-tau), neurofilament light, and phosphorylated neurofilament heavy protein were measured using single molecule arrays. Results: LiHep demonstrated the highest mean value for all biomarkers. Tube types were highly correlated for most biomarkers (r > 0.95) but gave significantly different absolute concentrations. Weaker correlations between tube types were found for Aβ42/40 (r = 0.63-0.86) and serum t-tau (r = 0.46-0.64). Freeze-thaw cycles highly influenced levels of serum Aβ and t-tau (P < .0001), and minor decreases in EDTA Aβ40 and EDTA p-tau181 were found after freeze-thaw cycle 4 (P < .05). Discussion: The same tube type should be used in research studies on blood biomarkers. Individual concentration cut-offs are needed for each tube type in all tested biomarkers despite being highly correlated. Serum should be avoided for Aβ42, Aβ40, and t-tau. Freeze-thaw cycles > 3 should be avoided for p-tau181."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://purl.org/dc/terms/date> "2021-06-02" .
<https://discovery.ucl.ac.uk/id/document/1335234> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://purl.org/ontology/bibo/volume> "13" .
<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://purl.org/ontology/bibo/issue> "1" .
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<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130389#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130389#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-59f454bc02ee6f1635c093a66a9c8538> .
<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130389#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10130389#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-59f454bc02ee6f1635c093a66a9c8538> .
<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d9ccc35f7114ff342a0f360712939aa0> .
<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130389#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6d45163ba2a3d600ae87b1f22c7f7ad8> .
<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130389#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-999fb7ca048e138edc14f11fe6d2d461> .
<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130389#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10130389#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-999fb7ca048e138edc14f11fe6d2d461> .
<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2e0cd8bda8c3017470f588db0c8e2e1e> .
<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130389#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10130389#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-2e0cd8bda8c3017470f588db0c8e2e1e> .
<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5bac97103a1dfc9dd270256f8157abda> .
<https://discovery.ucl.ac.uk/id/eprint/10130389> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10130389#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10130389#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-5bac97103a1dfc9dd270256f8157abda> .
<https://discovery.ucl.ac.uk/id/person/ext-2e0cd8bda8c3017470f588db0c8e2e1e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2e0cd8bda8c3017470f588db0c8e2e1e> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2e0cd8bda8c3017470f588db0c8e2e1e> <http://xmlns.com/foaf/0.1/familyName> "Blennow"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2e0cd8bda8c3017470f588db0c8e2e1e> <http://xmlns.com/foaf/0.1/name> "K Blennow"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5bac97103a1dfc9dd270256f8157abda> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5bac97103a1dfc9dd270256f8157abda> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5bac97103a1dfc9dd270256f8157abda> <http://xmlns.com/foaf/0.1/familyName> "Zetterberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5bac97103a1dfc9dd270256f8157abda> <http://xmlns.com/foaf/0.1/name> "H Zetterberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-59f454bc02ee6f1635c093a66a9c8538> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-59f454bc02ee6f1635c093a66a9c8538> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-59f454bc02ee6f1635c093a66a9c8538> <http://xmlns.com/foaf/0.1/familyName> "Sauer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-59f454bc02ee6f1635c093a66a9c8538> <http://xmlns.com/foaf/0.1/name> "M Sauer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d5f0cb0f7505efd90536ca16366105da> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d5f0cb0f7505efd90536ca16366105da> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d5f0cb0f7505efd90536ca16366105da> <http://xmlns.com/foaf/0.1/familyName> "Lantero-Rodriguez"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d5f0cb0f7505efd90536ca16366105da> <http://xmlns.com/foaf/0.1/name> "J Lantero-Rodriguez"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6d45163ba2a3d600ae87b1f22c7f7ad8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-6d45163ba2a3d600ae87b1f22c7f7ad8> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6d45163ba2a3d600ae87b1f22c7f7ad8> <http://xmlns.com/foaf/0.1/familyName> "Minguillon"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6d45163ba2a3d600ae87b1f22c7f7ad8> <http://xmlns.com/foaf/0.1/name> "C Minguillon"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1f8230781db22f8f678e09a70d7d1a07> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1f8230781db22f8f678e09a70d7d1a07> <http://xmlns.com/foaf/0.1/givenName> "NJ"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1f8230781db22f8f678e09a70d7d1a07> <http://xmlns.com/foaf/0.1/familyName> "Ashton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1f8230781db22f8f678e09a70d7d1a07> <http://xmlns.com/foaf/0.1/name> "NJ Ashton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-999fb7ca048e138edc14f11fe6d2d461> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-999fb7ca048e138edc14f11fe6d2d461> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-999fb7ca048e138edc14f11fe6d2d461> <http://xmlns.com/foaf/0.1/familyName> "Fauria"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-999fb7ca048e138edc14f11fe6d2d461> <http://xmlns.com/foaf/0.1/name> "K Fauria"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/person/ext-d9ccc35f7114ff342a0f360712939aa0> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d9ccc35f7114ff342a0f360712939aa0> <http://xmlns.com/foaf/0.1/familyName> "Simrén"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d9ccc35f7114ff342a0f360712939aa0> <http://xmlns.com/foaf/0.1/name> "J Simrén"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-247bea0c3a0b129edef92f3204aec878> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-247bea0c3a0b129edef92f3204aec878> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-247bea0c3a0b129edef92f3204aec878> <http://xmlns.com/foaf/0.1/familyName> "Suárez-Calvet"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-247bea0c3a0b129edef92f3204aec878> <http://xmlns.com/foaf/0.1/name> "M Suárez-Calvet"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-76244d07e8af502358462aa371318efe> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-76244d07e8af502358462aa371318efe> <http://xmlns.com/foaf/0.1/givenName> "TK"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-76244d07e8af502358462aa371318efe> <http://xmlns.com/foaf/0.1/familyName> "Karikari"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-76244d07e8af502358462aa371318efe> <http://xmlns.com/foaf/0.1/name> "TK Karikari"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a21d7d8252552d514f1a15d10dd90992> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a21d7d8252552d514f1a15d10dd90992> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a21d7d8252552d514f1a15d10dd90992> <http://xmlns.com/foaf/0.1/familyName> "Snellman"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a21d7d8252552d514f1a15d10dd90992> <http://xmlns.com/foaf/0.1/name> "A Snellman"^^<http://www.w3.org/2001/XMLSchema#string> .
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