TY - JOUR N1 - This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/). UR - https://doi.org/10.2991/artres.k.201124.001 ID - discovery10130265 PB - ATLANTIS PRESS JF - Artery Research SP - 59 N2 - In December 2019, an outbreak of pneumonia caused by a novel Coronavirus (COVID-19) spread rapidly worldwide. Although the clinical manifestations of COVID-19 are dominated by respiratory symptoms, the cardiovascular system is extensively affected at multiple levels. Due to the unprecedented consequences of the COVID-19 pandemic, the ARTERY society decided to launch the Covid-19 effects on ARTErial StIffness and vascular AgeiNg (CARTESIAN) study ? the first international multicentre study into the effects of COVID-19 on non-invasive biomarkers of vascular ageing. The main study objective is to evaluate the presence of Early Vascular Ageing (EVA) 6 and 12 months after COVID-19 infection. Secondary objectives are to study the effect of COVID-19 disease severity on EVA, to investigate the role of psychosocial factors in COVID-19 induced EVA, and to investigate the potential modifying effect of comorbidities and chronic treatments. In the CARTESIAN study, a broad array of cardiovascular measurements, including carotid-femoral pulse wave velocity, central blood pressure, carotid ultrasound, brachial flow-mediated dilatation, will be performed. To date, 43 centres from 21 countries have agreed to participate, with an expected study population of >2500 individuals. To our knowledge, CARTESIAN will be the first study to provide insight into the relationship between COVID-19, its severity, and early vascular ageing in a large cohort, potentially enabling future care and diagnostics to be more focused on the most vulnerable. AV - public TI - Covid-19 Effects on ARTErial StIffness and Vascular AgeiNg: CARTESIAN Study Rationale and Protocol Y1 - 2021/06// VL - 27 EP - 68 KW - COVID-19 KW - coronavirus KW - inflammation KW - vascular ageing KW - arterial stiffness A1 - Bruno, RM A1 - Spronck, B A1 - Hametner, B A1 - Hughes, A A1 - Lacolley, P A1 - Mayer, CC A1 - Muiesan, ML A1 - Rajkumar, C A1 - Terentes-Printzios, D A1 - Weber, T A1 - Hansen, TW A1 - Boutouyrie, P IS - 2 ER -