TY  - JOUR
N1  - This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
UR  - https://doi.org/10.2991/artres.k.201124.001
ID  - discovery10130265
PB  - ATLANTIS PRESS
JF  - Artery Research
SP  - 59
N2  - In December 2019, an outbreak of pneumonia caused by a novel Coronavirus (COVID-19) spread rapidly worldwide. Although the clinical manifestations of COVID-19 are dominated by respiratory symptoms, the cardiovascular system is extensively affected at multiple levels. Due to the unprecedented consequences of the COVID-19 pandemic, the ARTERY society decided to launch the Covid-19 effects on ARTErial StIffness and vascular AgeiNg (CARTESIAN) study ? the first international multicentre study into the effects of COVID-19 on non-invasive biomarkers of vascular ageing. The main study objective is to evaluate the presence of Early Vascular Ageing (EVA) 6 and 12 months after COVID-19 infection. Secondary objectives are to study the effect of COVID-19 disease severity on EVA, to investigate the role of psychosocial factors in COVID-19 induced EVA, and to investigate the potential modifying effect of comorbidities and chronic treatments. In the CARTESIAN study, a broad array of cardiovascular measurements, including carotid-femoral pulse wave velocity, central blood pressure, carotid ultrasound, brachial flow-mediated dilatation, will be performed. To date, 43 centres from 21 countries have agreed to participate, with an expected study population of >2500 individuals. To our knowledge, CARTESIAN will be the first study to provide insight into the relationship between COVID-19, its severity, and early vascular ageing in a large cohort, potentially enabling future care and diagnostics to be more focused on the most vulnerable.
AV  - public
TI  - Covid-19 Effects on ARTErial StIffness and Vascular AgeiNg: CARTESIAN Study Rationale and Protocol
Y1  - 2021/06//
VL  - 27
EP  - 68
KW  - COVID-19
KW  -  coronavirus
KW  -  inflammation
KW  -  vascular ageing
KW  -  arterial stiffness
A1  - Bruno, RM
A1  - Spronck, B
A1  - Hametner, B
A1  - Hughes, A
A1  - Lacolley, P
A1  - Mayer, CC
A1  - Muiesan, ML
A1  - Rajkumar, C
A1  - Terentes-Printzios, D
A1  - Weber, T
A1  - Hansen, TW
A1  - Boutouyrie, P
IS  - 2
ER  -