eprintid: 10129787 rev_number: 14 eprint_status: archive userid: 608 dir: disk0/10/12/97/87 datestamp: 2022-07-01 18:44:16 lastmod: 2022-07-01 18:44:16 status_changed: 2022-07-01 18:44:16 type: article metadata_visibility: show creators_name: Spinou, A creators_name: Fragkos, KC creators_name: Lee, KK creators_name: Elston, C creators_name: Siegert, RJ creators_name: Loebinger, MR creators_name: Wilson, R creators_name: Garrod, R creators_name: Birring, SS title: The validity of health-related quality of life questionnaires in bronchiectasis: a systematic review and meta-analysis ispublished: pub divisions: UCL divisions: B02 divisions: C10 divisions: D17 keywords: health-related quality of life, questionnaire, bronchiectasis, systematic literature review, meta-analysis note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Background: A range of questionnaires have been used to assess health-related quality of life (HRQOL) in bronchiectasis. A systematic review was conducted to evaluate their psychometric properties and assess associations between HRQOL and clinical measures. Methods: Five electronic databases were searched. Studies eligible for inclusion were those that investigated the validity of HRQOL questionnaires and/or their association with other outcomes in adults with bronchiectasis. Patients with cystic fibrosis were excluded. The identified questionnaires were assessed for convergent, discriminant and cross-cultural translation validity; missing data, floor and ceiling effects, internal consistency, responsiveness and test-retest reliability. A meta-analysis was conducted to estimate the strength of associations between HRQOL and clinical measures. Results: From 1918 studies identified, 43 studies were included in the systematic review, of which 38 were suitable for the meta-analysis. Nine HRQOL questionnaires were identified, with the most widely used being: St George's Respiratory Questionnaire, Leicester Cough Questionnaire, Quality of Life–Bronchiectasis and Short Form-36. HRQOL questionnaires had moderate to good internal consistency and good test-retest reliability. Only 8 of 18 studies that used translated HRQOL questionnaires reported or referred to the validity of the translated questionnaire. There was a stronger correlation (mean r (95% CI)) between HRQOL and subjective outcome measures, such as dyspnoea (0.55 (0.41 to 0.68)) and fatigue (0.42 (0.23 to 0.58)) compared with objective measures; exercise capacity (−0.41 (−0.54 to −0.24)), FEV1% predicted (−0.31 (−0.40 to −0.23)) and extent of bronchiectasis on CT scan (0.35 (0.03 to 0.61)); all p<0.001. Conclusions: This review supports most HRQOL questionnaires used in bronchiectasis have good psychometric properties. There was a weak to moderate association between HRQOL and objective outcome measures. This suggests that HRQOL questionnaires assess a unique aspect of health not captured by objective measures. date: 2016-08-01 date_type: published publisher: BMJ PUBLISHING GROUP official_url: https://doi.org/10.1136/thoraxjnl-2015-207315 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1870368 doi: 10.1136/thoraxjnl-2015-207315 lyricists_name: Fragkos, Konstantinos lyricists_id: FKONS73 actors_name: Fragkos, Konstantinos actors_id: FKONS73 actors_role: owner full_text_status: public publication: Thorax volume: 71 number: 8 pagerange: 683-694 pages: 12 issn: 1468-3296 citation: Spinou, A; Fragkos, KC; Lee, KK; Elston, C; Siegert, RJ; Loebinger, MR; Wilson, R; ... Birring, SS; + view all <#> Spinou, A; Fragkos, KC; Lee, KK; Elston, C; Siegert, RJ; Loebinger, MR; Wilson, R; Garrod, R; Birring, SS; - view fewer <#> (2016) The validity of health-related quality of life questionnaires in bronchiectasis: a systematic review and meta-analysis. Thorax , 71 (8) pp. 683-694. 10.1136/thoraxjnl-2015-207315 <https://doi.org/10.1136/thoraxjnl-2015-207315>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10129787/1/Bronchiectasis_QOL_thorax_full_180515_1.pdf