TY  - JOUR
EP  - 694
AV  - public
Y1  - 2016/08/01/
TI  - The validity of health-related quality of life questionnaires in bronchiectasis: a systematic review and meta-analysis
KW  - health-related quality of life
KW  -  questionnaire
KW  -  bronchiectasis
KW  -  systematic literature
review
KW  -  meta-analysis
PB  - BMJ PUBLISHING GROUP
ID  - discovery10129787
N2  - Background: A range of questionnaires have been used to assess health-related quality of life (HRQOL) in bronchiectasis. A systematic review was conducted to evaluate their psychometric properties and assess associations between HRQOL and clinical measures.

Methods: Five electronic databases were searched. Studies eligible for inclusion were those that investigated the validity of HRQOL questionnaires and/or their association with other outcomes in adults with bronchiectasis. Patients with cystic fibrosis were excluded. The identified questionnaires were assessed for convergent, discriminant and cross-cultural translation validity; missing data, floor and ceiling effects, internal consistency, responsiveness and test-retest reliability. A meta-analysis was conducted to estimate the strength of associations between HRQOL and clinical measures.

Results: From 1918 studies identified, 43 studies were included in the systematic review, of which 38 were suitable for the meta-analysis. Nine HRQOL questionnaires were identified, with the most widely used being: St George's Respiratory Questionnaire, Leicester Cough Questionnaire, Quality of Life?Bronchiectasis and Short Form-36. HRQOL questionnaires had moderate to good internal consistency and good test-retest reliability. Only 8 of 18 studies that used translated HRQOL questionnaires reported or referred to the validity of the translated questionnaire. There was a stronger correlation (mean r (95% CI)) between HRQOL and subjective outcome measures, such as dyspnoea (0.55 (0.41 to 0.68)) and fatigue (0.42 (0.23 to 0.58)) compared with objective measures; exercise capacity (?0.41 (?0.54 to ?0.24)), FEV1% predicted (?0.31 (?0.40 to ?0.23)) and extent of bronchiectasis on CT scan (0.35 (0.03 to 0.61)); all p<0.001.

Conclusions: This review supports most HRQOL questionnaires used in bronchiectasis have good psychometric properties. There was a weak to moderate association between HRQOL and objective outcome measures. This suggests that HRQOL questionnaires assess a unique aspect of health not captured by objective measures.
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
IS  - 8
SP  - 683
VL  - 71
A1  - Spinou, A
A1  - Fragkos, KC
A1  - Lee, KK
A1  - Elston, C
A1  - Siegert, RJ
A1  - Loebinger, MR
A1  - Wilson, R
A1  - Garrod, R
A1  - Birring, SS
JF  - Thorax
SN  - 1468-3296
UR  - https://doi.org/10.1136/thoraxjnl-2015-207315
ER  -