eprintid: 10129615
rev_number: 18
eprint_status: archive
userid: 608
dir: disk0/10/12/96/15
datestamp: 2021-06-16 09:36:14
lastmod: 2021-11-10 01:56:47
status_changed: 2021-06-16 09:36:14
type: article
metadata_visibility: show
creators_name: Ashton, NJ
creators_name: Janelidze, S
creators_name: Al Khleifat, A
creators_name: Leuzy, A
creators_name: van der Ende, EL
creators_name: Karikari, TK
creators_name: Benedet, AL
creators_name: Pascoal, TA
creators_name: Lleó, A
creators_name: Parnetti, L
creators_name: Galimberti, D
creators_name: Bonanni, L
creators_name: Pilotto, A
creators_name: Padovani, A
creators_name: Lycke, J
creators_name: Novakova, L
creators_name: Axelsson, M
creators_name: Velayudhan, L
creators_name: Rabinovici, GD
creators_name: Miller, B
creators_name: Pariante, C
creators_name: Nikkheslat, N
creators_name: Resnick, SM
creators_name: Thambisetty, M
creators_name: Schöll, M
creators_name: Fernández-Eulate, G
creators_name: Gil-Bea, FJ
creators_name: López de Munain, A
creators_name: Al-Chalabi, A
creators_name: Rosa-Neto, P
creators_name: Strydom, A
creators_name: Svenningsson, P
creators_name: Stomrud, E
creators_name: Santillo, A
creators_name: Aarsland, D
creators_name: van Swieten, JC
creators_name: Palmqvist, S
creators_name: Zetterberg, H
creators_name: Blennow, K
creators_name: Hye, A
creators_name: Hansson, O
title: A multicentre validation study of the diagnostic value of plasma neurofilament light.
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D79
divisions: D07
divisions: F86
note: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
abstract: Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King’s College London (n = 805) and the Swedish BioFINDER study (n = 1,464). Plasma NfL was significantly increased in all cortical neurodegenerative disorders, amyotrophic lateral sclerosis and atypical parkinsonian disorders. We demonstrate that plasma NfL is clinically useful in identifying atypical parkinsonian disorders in patients with parkinsonism, dementia in individuals with Down syndrome, dementia among psychiatric disorders, and frontotemporal dementia in patients with cognitive impairment. Data-driven cut-offs highlighted the fundamental importance of age-related clinical cut-offs for disorders with a younger age of onset. Finally, plasma NfL performs best when applied to indicate no underlying neurodegeneration, with low false positives, in all age-related cut-offs.
date: 2021-06-07
date_type: published
official_url: https://doi.org/10.1038/s41467-021-23620-z
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1870505
doi: 10.1038/s41467-021-23620-z
pii: 10.1038/s41467-021-23620-z
lyricists_name: Scholl, Michael
lyricists_name: Strydom, Andre
lyricists_name: Zetterberg, Henrik
lyricists_id: MSCHO84
lyricists_id: ASTRY65
lyricists_id: HZETT94
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Nature Communications
volume: 12
number: 1
article_number: 3400
event_location: England
citation:        Ashton, NJ;    Janelidze, S;    Al Khleifat, A;    Leuzy, A;    van der Ende, EL;    Karikari, TK;    Benedet, AL;                                                                                                                                         ... Hansson, O; + view all <#>        Ashton, NJ;  Janelidze, S;  Al Khleifat, A;  Leuzy, A;  van der Ende, EL;  Karikari, TK;  Benedet, AL;  Pascoal, TA;  Lleó, A;  Parnetti, L;  Galimberti, D;  Bonanni, L;  Pilotto, A;  Padovani, A;  Lycke, J;  Novakova, L;  Axelsson, M;  Velayudhan, L;  Rabinovici, GD;  Miller, B;  Pariante, C;  Nikkheslat, N;  Resnick, SM;  Thambisetty, M;  Schöll, M;  Fernández-Eulate, G;  Gil-Bea, FJ;  López de Munain, A;  Al-Chalabi, A;  Rosa-Neto, P;  Strydom, A;  Svenningsson, P;  Stomrud, E;  Santillo, A;  Aarsland, D;  van Swieten, JC;  Palmqvist, S;  Zetterberg, H;  Blennow, K;  Hye, A;  Hansson, O;   - view fewer <#>    (2021)    A multicentre validation study of the diagnostic value of plasma neurofilament light.                   Nature Communications , 12  (1)    , Article 3400.  10.1038/s41467-021-23620-z <https://doi.org/10.1038/s41467-021-23620-z>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10129615/1/s41467-021-23620-z.pdf