eprintid: 10129615 rev_number: 18 eprint_status: archive userid: 608 dir: disk0/10/12/96/15 datestamp: 2021-06-16 09:36:14 lastmod: 2021-11-10 01:56:47 status_changed: 2021-06-16 09:36:14 type: article metadata_visibility: show creators_name: Ashton, NJ creators_name: Janelidze, S creators_name: Al Khleifat, A creators_name: Leuzy, A creators_name: van der Ende, EL creators_name: Karikari, TK creators_name: Benedet, AL creators_name: Pascoal, TA creators_name: Lleó, A creators_name: Parnetti, L creators_name: Galimberti, D creators_name: Bonanni, L creators_name: Pilotto, A creators_name: Padovani, A creators_name: Lycke, J creators_name: Novakova, L creators_name: Axelsson, M creators_name: Velayudhan, L creators_name: Rabinovici, GD creators_name: Miller, B creators_name: Pariante, C creators_name: Nikkheslat, N creators_name: Resnick, SM creators_name: Thambisetty, M creators_name: Schöll, M creators_name: Fernández-Eulate, G creators_name: Gil-Bea, FJ creators_name: López de Munain, A creators_name: Al-Chalabi, A creators_name: Rosa-Neto, P creators_name: Strydom, A creators_name: Svenningsson, P creators_name: Stomrud, E creators_name: Santillo, A creators_name: Aarsland, D creators_name: van Swieten, JC creators_name: Palmqvist, S creators_name: Zetterberg, H creators_name: Blennow, K creators_name: Hye, A creators_name: Hansson, O title: A multicentre validation study of the diagnostic value of plasma neurofilament light. ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D79 divisions: D07 divisions: F86 note: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. abstract: Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King’s College London (n = 805) and the Swedish BioFINDER study (n = 1,464). Plasma NfL was significantly increased in all cortical neurodegenerative disorders, amyotrophic lateral sclerosis and atypical parkinsonian disorders. We demonstrate that plasma NfL is clinically useful in identifying atypical parkinsonian disorders in patients with parkinsonism, dementia in individuals with Down syndrome, dementia among psychiatric disorders, and frontotemporal dementia in patients with cognitive impairment. Data-driven cut-offs highlighted the fundamental importance of age-related clinical cut-offs for disorders with a younger age of onset. Finally, plasma NfL performs best when applied to indicate no underlying neurodegeneration, with low false positives, in all age-related cut-offs. date: 2021-06-07 date_type: published official_url: https://doi.org/10.1038/s41467-021-23620-z oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1870505 doi: 10.1038/s41467-021-23620-z pii: 10.1038/s41467-021-23620-z lyricists_name: Scholl, Michael lyricists_name: Strydom, Andre lyricists_name: Zetterberg, Henrik lyricists_id: MSCHO84 lyricists_id: ASTRY65 lyricists_id: HZETT94 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: Nature Communications volume: 12 number: 1 article_number: 3400 event_location: England citation: Ashton, NJ; Janelidze, S; Al Khleifat, A; Leuzy, A; van der Ende, EL; Karikari, TK; Benedet, AL; ... Hansson, O; + view all <#> Ashton, NJ; Janelidze, S; Al Khleifat, A; Leuzy, A; van der Ende, EL; Karikari, TK; Benedet, AL; Pascoal, TA; Lleó, A; Parnetti, L; Galimberti, D; Bonanni, L; Pilotto, A; Padovani, A; Lycke, J; Novakova, L; Axelsson, M; Velayudhan, L; Rabinovici, GD; Miller, B; Pariante, C; Nikkheslat, N; Resnick, SM; Thambisetty, M; Schöll, M; Fernández-Eulate, G; Gil-Bea, FJ; López de Munain, A; Al-Chalabi, A; Rosa-Neto, P; Strydom, A; Svenningsson, P; Stomrud, E; Santillo, A; Aarsland, D; van Swieten, JC; Palmqvist, S; Zetterberg, H; Blennow, K; Hye, A; Hansson, O; - view fewer <#> (2021) A multicentre validation study of the diagnostic value of plasma neurofilament light. Nature Communications , 12 (1) , Article 3400. 10.1038/s41467-021-23620-z <https://doi.org/10.1038/s41467-021-23620-z>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10129615/1/s41467-021-23620-z.pdf