@article{discovery10129615,
            note = {This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.},
          number = {1},
         journal = {Nature Communications},
           title = {A multicentre validation study of the diagnostic value of plasma neurofilament light.},
            year = {2021},
          volume = {12},
           month = {June},
        abstract = {Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King's College London (nā€‰=ā€‰805) and the Swedish BioFINDER study (nā€‰=ā€‰1,464). Plasma NfL was significantly increased in all cortical neurodegenerative disorders, amyotrophic lateral sclerosis and atypical parkinsonian disorders. We demonstrate that plasma NfL is clinically useful in identifying atypical parkinsonian disorders in patients with parkinsonism, dementia in individuals with Down syndrome, dementia among psychiatric disorders, and frontotemporal dementia in patients with cognitive impairment. Data-driven cut-offs highlighted the fundamental importance of age-related clinical cut-offs for disorders with a younger age of onset. Finally, plasma NfL performs best when applied to indicate no underlying neurodegeneration, with low false positives, in all age-related cut-offs.},
          author = {Ashton, NJ and Janelidze, S and Al Khleifat, A and Leuzy, A and van der Ende, EL and Karikari, TK and Benedet, AL and Pascoal, TA and Lle{\'o}, A and Parnetti, L and Galimberti, D and Bonanni, L and Pilotto, A and Padovani, A and Lycke, J and Novakova, L and Axelsson, M and Velayudhan, L and Rabinovici, GD and Miller, B and Pariante, C and Nikkheslat, N and Resnick, SM and Thambisetty, M and Sch{\"o}ll, M and Fern{\'a}ndez-Eulate, G and Gil-Bea, FJ and L{\'o}pez de Munain, A and Al-Chalabi, A and Rosa-Neto, P and Strydom, A and Svenningsson, P and Stomrud, E and Santillo, A and Aarsland, D and van Swieten, JC and Palmqvist, S and Zetterberg, H and Blennow, K and Hye, A and Hansson, O},
             url = {https://doi.org/10.1038/s41467-021-23620-z}
}