eprintid: 10128003
rev_number: 20
eprint_status: archive
userid: 608
dir: disk0/10/12/80/03
datestamp: 2021-05-18 11:20:13
lastmod: 2022-07-01 06:10:41
status_changed: 2021-05-18 11:20:13
type: article
metadata_visibility: show
creators_name: Walker, J
creators_name: Mulick, A
creators_name: Magill, N
creators_name: Symeonides, S
creators_name: Gourley, C
creators_name: Burke, K
creators_name: Belot, A
creators_name: Quartagno, M
creators_name: van Niekerk, M
creators_name: Toynbee, M
creators_name: Frost, C
creators_name: Sharpe, M
title: Major depression and survival in people with cancer
ispublished: pub
divisions: UCL
divisions: B02
divisions: D65
divisions: J38
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: OBJECTIVE: The question of whether depression is associated with worse survival in people with cancer remains unanswered because of methodological criticism of the published research on the topic. We aimed to study the association in a large methodologically robust study. METHODS: We analysed data on 20,582 patients with breast, colorectal, gynaecological, lung and prostate cancers who had attended cancer outpatient clinics in Scotland, UK. Patients had completed two-stage screening for major depression as part of their cancer care. These data on depression status were linked to demographic, cancer and subsequent mortality data from national databases. We estimated the association of major depression with survival for each cancer using Cox regression. We adjusted for potential confounders and interactions between potentially time-varying confounders and the interval between cancer diagnosis and depression screening, and used multiple imputation for missing depression and confounder data. We pooled the cancer-specific results using fixed-effects meta-analysis. RESULTS: Major depression was associated with worse survival for all cancers, with similar adjusted hazard ratios: breast cancer (HR 1.42, 95% CI 1.15-1.75), colorectal cancer (HR 1.47, 95% CI 1.11-1.94), gynaecological cancer (HR 1.36, 95% CI 1.08-1.71), lung cancer (HR 1.39, 95% CI 1.24-1.56), prostate cancer (HR 1.76, 95% CI 1.08-2.85). The pooled hazard ratio was 1.41 (95% CI 1.29-1.54, p<0.001, I2=0%). These findings were not materially different when we only considered the deaths (90%) that were attributed to cancer. CONCLUSIONS: Major depression is associated with worse survival in patients with common cancers. The mechanisms of this association and the clinical implications require further study.
date: 2021-06
date_type: published
official_url: http://doi.org/10.1097/PSY.0000000000000942
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1865109
doi: 10.1097/PSY.0000000000000942
pii: 00006842-900000000-98426
lyricists_name: Quartagno, Matteo
lyricists_id: MQUAR28
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Psychosomatic Medicine
volume: 83
number: 5
pagerange: 410-416
event_location: United States
citation:        Walker, J;    Mulick, A;    Magill, N;    Symeonides, S;    Gourley, C;    Burke, K;    Belot, A;                     ... Sharpe, M; + view all <#>        Walker, J;  Mulick, A;  Magill, N;  Symeonides, S;  Gourley, C;  Burke, K;  Belot, A;  Quartagno, M;  van Niekerk, M;  Toynbee, M;  Frost, C;  Sharpe, M;   - view fewer <#>    (2021)    Major depression and survival in people with cancer.                   Psychosomatic Medicine , 83  (5)   pp. 410-416.    10.1097/PSY.0000000000000942 <https://doi.org/10.1097/PSY.0000000000000942>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10128003/1/MAJOR_DEPRESSION_AND_SURVIVAL_IN_PEOPLE_WITH.98426.pdf