eprintid: 10126138 rev_number: 14 eprint_status: archive userid: 608 dir: disk0/10/12/61/38 datestamp: 2021-04-20 15:28:23 lastmod: 2021-10-02 22:11:00 status_changed: 2021-04-20 15:28:23 type: article metadata_visibility: show creators_name: Al Khleifat, A creators_name: Balendra, R creators_name: Fang, T creators_name: Al-Chalabi, A title: Intuitive Staging Correlates With King's Clinical Stage. ispublished: inpress divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F86 keywords: King’s stage, Prognosis, biomarker, clinical stage, prognostic, survival, ventilation note: © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http:// creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. abstract: BACKGROUND: Clinical stage in amyotrophic lateral sclerosis (ALS) can be assigned using King's staging with a simple protocol based on the number of CNS regions involved and the presence of significant nutritional or respiratory failure. It is important that the assigned clinical stage matches expectations, and generally corresponds with how a health care professional would intuitively stage the patient. We therefore investigated the relationship between King's clinical ALS stage and ALS stage as intuitively assigned by health care professionals. METHODS: We wrote 17 case vignettes describing people with ALS at different disease stages from very early limited disease involvement through to severe, multi-domain disease. During two workshops, we asked health care professionals to intuitively stage the vignettes and compared the answers with the actual King's clinical ALS stage. RESULTS: There was a good correlation between King's clinical ALS stage and intuitively assigned stage, with a Spearman's Rank correlation coefficient of 0.64 (p < 0.001). There was no difference in the intuitive stages assigned by practitioners of different types or at different levels of experience. CONCLUSIONS: Across a spectrum of ALS scenarios, King's clinical ALS stage corresponds to intuitive ALS stage as assigned by a range of health care professionals. date: 2021-04-06 date_type: published official_url: https://doi.org/10.1080/21678421.2020.1867181 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1857748 doi: 10.1080/21678421.2020.1867181 lyricists_name: Balendra, Rubika lyricists_id: RBALE22 actors_name: Balendra, Rubika actors_id: RBALE22 actors_role: owner full_text_status: public publication: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration event_location: England citation: Al Khleifat, A; Balendra, R; Fang, T; Al-Chalabi, A; (2021) Intuitive Staging Correlates With King's Clinical Stage. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 10.1080/21678421.2020.1867181 <https://doi.org/10.1080/21678421.2020.1867181>. (In press). Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10126138/1/21678421.2020.pdf