eprintid: 10126138
rev_number: 14
eprint_status: archive
userid: 608
dir: disk0/10/12/61/38
datestamp: 2021-04-20 15:28:23
lastmod: 2021-10-02 22:11:00
status_changed: 2021-04-20 15:28:23
type: article
metadata_visibility: show
creators_name: Al Khleifat, A
creators_name: Balendra, R
creators_name: Fang, T
creators_name: Al-Chalabi, A
title: Intuitive Staging Correlates With King's Clinical Stage.
ispublished: inpress
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F86
keywords: King’s stage, Prognosis, biomarker, clinical stage, prognostic, survival, ventilation
note: © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://
creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original
work is properly cited, and is not altered, transformed, or built upon in any way.
abstract: BACKGROUND: Clinical stage in amyotrophic lateral sclerosis (ALS) can be assigned using King's staging with a simple protocol based on the number of CNS regions involved and the presence of significant nutritional or respiratory failure. It is important that the assigned clinical stage matches expectations, and generally corresponds with how a health care professional would intuitively stage the patient. We therefore investigated the relationship between King's clinical ALS stage and ALS stage as intuitively assigned by health care professionals. 

METHODS: We wrote 17 case vignettes describing people with ALS at different disease stages from very early limited disease involvement through to severe, multi-domain disease. During two workshops, we asked health care professionals to intuitively stage the vignettes and compared the answers with the actual King's clinical ALS stage. 

RESULTS: There was a good correlation between King's clinical ALS stage and intuitively assigned stage, with a Spearman's Rank correlation coefficient of 0.64 (p < 0.001). There was no difference in the intuitive stages assigned by practitioners of different types or at different levels of experience. 

CONCLUSIONS: Across a spectrum of ALS scenarios, King's clinical ALS stage corresponds to intuitive ALS stage as assigned by a range of health care professionals.
date: 2021-04-06
date_type: published
official_url: https://doi.org/10.1080/21678421.2020.1867181
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1857748
doi: 10.1080/21678421.2020.1867181
lyricists_name: Balendra, Rubika
lyricists_id: RBALE22
actors_name: Balendra, Rubika
actors_id: RBALE22
actors_role: owner
full_text_status: public
publication: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
event_location: England
citation:        Al Khleifat, A;    Balendra, R;    Fang, T;    Al-Chalabi, A;      (2021)    Intuitive Staging Correlates With King's Clinical Stage.                   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration        10.1080/21678421.2020.1867181 <https://doi.org/10.1080/21678421.2020.1867181>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10126138/1/21678421.2020.pdf