eprintid: 10125770 rev_number: 17 eprint_status: archive userid: 608 dir: disk0/10/12/57/70 datestamp: 2021-04-16 12:27:15 lastmod: 2021-12-06 00:09:48 status_changed: 2021-04-16 12:27:15 type: article metadata_visibility: show creators_name: Espinosa-Medina, I creators_name: Jevans, B creators_name: Boismoreau, F creators_name: Chettouh, Z creators_name: Enomoto, H creators_name: Mueller, T creators_name: Birchmeier, C creators_name: Burns, AJ creators_name: Brunet, J-F title: Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest ispublished: pub divisions: UCL divisions: B02 divisions: D13 divisions: G22 keywords: Enteric nervous system, neural crest, chicken, mouse, Neuregulin1 note: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Most of the enteric nervous system derives from the “vagal” neural crest, lying at the level of somites 1–7, which invades the digestive tract rostro-caudally from the foregut to the hindgut. Little is known about the initial phase of this colonization, which brings enteric precursors into the foregut. Here we show that the “vagal crest” subsumes two populations of enteric precursors with contrasted origins, initial modes of migration, and destinations. Crest cells adjacent to somites 1 and 2 produce Schwann cell precursors that colonize the vagus nerve, which in turn guides them into the esophagus and stomach. Crest cells adjacent to somites 3–7 belong to the crest streams contributing to sympathetic chains: they migrate ventrally, seed the sympathetic chains, and colonize the entire digestive tract thence. Accordingly, enteric ganglia, like sympathetic ones, are atrophic when deprived of signaling through the tyrosine kinase receptor ErbB3, while half of the esophageal ganglia require, like parasympathetic ones, the nerve-associated form of the ErbB3 ligand, Neuregulin-1. These dependencies might bear relevance to Hirschsprung disease, with which alleles of Neuregulin-1 are associated. date: 2017-11-07 date_type: published publisher: NATL ACAD SCIENCES official_url: https://doi.org/10.1073/pnas.1710308114 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1504160 doi: 10.1073/pnas.1710308114 lyricists_name: Burns, Alan lyricists_name: Jevans, Benjamin lyricists_id: AJBUR26 lyricists_id: JEVAN27 actors_name: Jevans, Benjamin actors_id: JEVAN27 actors_role: owner full_text_status: public publication: Proceedings of the National Academy of Sciences volume: 114 number: 45 pagerange: 11980-11985 pages: 6 citation: Espinosa-Medina, I; Jevans, B; Boismoreau, F; Chettouh, Z; Enomoto, H; Mueller, T; Birchmeier, C; ... Brunet, J-F; + view all <#> Espinosa-Medina, I; Jevans, B; Boismoreau, F; Chettouh, Z; Enomoto, H; Mueller, T; Birchmeier, C; Burns, AJ; Brunet, J-F; - view fewer <#> (2017) Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest. Proceedings of the National Academy of Sciences , 114 (45) pp. 11980-11985. 10.1073/pnas.1710308114 <https://doi.org/10.1073/pnas.1710308114>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10125770/1/Espinosa-medina%20et%20al%2C%20PNAS%2C%202017.pdf