TY  - INPR
N2  - OBJECTIVE: We tested the hypothesis that plasma neurofilament light chain (NfL) identifies asymptomatic carriers of familial frontotemporal lobar degeneration (FTLD)-causing mutations at risk of disease progression. METHODS: Baseline plasma NfL concentrations were measured with Simoa in original (n = 277) and validation (n = 297) cohorts. C9orf72, GRN and MAPT mutation carriers and non-carriers from the same families were classified by disease severity [asymptomatic, prodromal and full phenotype] using the CDR® Dementia Staging Instrument plus behavior and language domains from the National Alzheimer's Disease Coordinating Center FTLD module (CDR®+NACC-FTLD). Linear mixed effect models related NfL to clinical variables. RESULTS: In both cohorts, baseline NfL was higher in asymptomatic mutation carriers who showed phenoconversion or disease progression compared to non-progressors (original: 11.4 ± 7 pg/mL vs. 6.7 ± 5 pg/mL, p = 0.002; validation: 14.1 ± 12 pg/mL vs. 8.7 ± 6 pg/mL, p = 0.035). Plasma NfL discriminated symptomatic from asymptomatic mutation carriers or prodromal disease (original cutoff: 13.6 pg/mL, 87.5% sensitivity, 82.7% specificity; validation cutoff: 19.8 pg/mL, 87.4% sensitivity, 84.3% specificity). Higher baseline NfL correlated with worse longitudinal CDR®+NACC-FTLD sum of boxes scores, neuropsychological function and atrophy, regardless of genotype or disease severity, including asymptomatic mutation carriers. CONCLUSIONS: Plasma NfL identifies asymptomatic carriers of FTLD-causing mutations at short-term risk of disease progression, and is a potential tool to select participants for prevention clinical trials. CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that in carriers of FTLD-causing mutations, elevation of plasma NfL predicts short-term risk of clinical progression.
ID  - discovery10125757
UR  - https://doi.org/10.1212/WNL.0000000000011848
TI  - Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration
Y1  - 2021/04/07/
AV  - public
A1  - Rojas, JC
A1  - Wang, P
A1  - Staffaroni, AM
A1  - Heller, C
A1  - Cobigo, Y
A1  - Wolf, A
A1  - Goh, S-YM
A1  - Ljubenkov, PA
A1  - Heuer, HW
A1  - Fong, JC
A1  - Taylor, JB
A1  - Veras, E
A1  - Song, L
A1  - Jeromin, A
A1  - Hanlon, D
A1  - Yu, L
A1  - Khinikar, A
A1  - Sivasankaran, R
A1  - Kieloch, A
A1  - Valentin, M-A
A1  - Karydas, AM
A1  - Mitic, LL
A1  - Pearlman, R
A1  - Kornak, J
A1  - Kramer, JH
A1  - Miller, BL
A1  - Kantarci, K
A1  - Knopman, DS
A1  - Graff-Radford, N
A1  - Petrucelli, L
A1  - Rademakers, R
A1  - Irwin, DJ
A1  - Grossman, M
A1  - Ramos, EM
A1  - Coppola, G
A1  - Mendez, MF
A1  - Bordelon, Y
A1  - Dickerson, BC
A1  - Ghoshal, N
A1  - Huey, ED
A1  - Mackenzie, IR
A1  - Appleby, BS
A1  - Domoto-Reilly, K
A1  - Hsiung, G-YR
A1  - Toga, AW
A1  - Weintraub, S
A1  - Kaufer, DI
A1  - Kerwin, D
A1  - Litvan, I
A1  - Onyike, CU
A1  - Pantelyat, A
A1  - Roberson, ED
A1  - Tartaglia, MC
A1  - Foroud, T
A1  - Chen, W
A1  - Czerkowicz, J
A1  - Graham, DL
A1  - van Swieten, JC
A1  - Borroni, B
A1  - Sanchez-Valle, R
A1  - Moreno, F
A1  - Laforce, R
A1  - Graff, C
A1  - Synofzik, M
A1  - Galimberti, D
A1  - Rowe, JB
A1  - Masellis, M
A1  - Finger, E
A1  - Vandenberghe, R
A1  - de Mendonça, A
A1  - Tagliavini, F
A1  - Santana, I
A1  - Ducharme, S
A1  - Butler, CR
A1  - Gerhard, A
A1  - Levin, J
A1  - Danek, A
A1  - Otto, M
A1  - Sorbi, S
A1  - Cash, DM
A1  - Convery, RS
A1  - Bocchetta, M
A1  - Foiani, M
A1  - Caroline V, G
A1  - Peakman, G
A1  - Russell, L
A1  - Swift, I
A1  - Todd, E
A1  - Rohrer, JD
A1  - Boeve, BF
A1  - Rosen, HJ
A1  - Boxer, AL
JF  - Neurology
N1  - © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0/).
ER  -