eprintid: 10124184
rev_number: 15
eprint_status: archive
userid: 608
dir: disk0/10/12/41/84
datestamp: 2021-03-18 15:14:00
lastmod: 2022-08-17 16:00:39
status_changed: 2021-03-18 15:14:00
type: article
metadata_visibility: show
creators_name: Mekhael, M
creators_name: Kristensen, HØ
creators_name: Larsen, HM
creators_name: Juul, T
creators_name: Emmanuel, A
creators_name: Krogh, K
creators_name: Christensen, P
title: Transanal Irrigation for Neurogenic Bowel Disease, Low Anterior Resection Syndrome, Faecal Incontinence and Chronic Constipation: A Systematic Review
ispublished: pub
subjects: UCH
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G91
keywords: transanal irrigation; neurogenic bowel dysfunction; low anterior resection syndrome; faecal incontinence; chronic constipation; bowel dysfunction; quality of life
note: This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
abstract: Transanal irrigation (TAI) has received increasing attention as a treatment option in patients with bowel dysfunction. This systematic review was conducted according to the PRISMA guidelines and evaluates the effect of TAI in neurogenic bowel dysfunction (NBD), low anterior resection syndrome (LARS), faecal incontinence (FI) and chronic constipation (CC). The primary outcome was the effect of TAI on bowel function. Secondary outcomes included details on TAI, quality of life (QoL), the discontinuation rate, adverse events, predictive factors for a successful outcome, and health economics. A systematic search for articles reporting original data on the effect of TAI on bowel function was performed, and 27 eligible studies including 1435 individuals were included. Three randomised controlled trials, one non-randomised trial, and 23 observational studies were included; 70% of the studies were assessed to be of excellent or good methodological quality. Results showed an improvement in bowel function among patients with NBD, LARS, FI, and CC with some studies showing improvement in QoL. However, discontinuation rates were high. Side effects were common, but equally prevalent among comparative treatments. No consistent predictive factors for a successful outcome were identified. Results from this review show that TAI improves bowel function and potentially QoL; however, evidence remains limited.
date: 2021-02-02
date_type: published
official_url: https://doi.org/10.3390/jcm10040753
oa_status: green
full_text_type: pub
pmcid: PMC7918662
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1853313
doi: 10.3390/jcm10040753
pii: jcm10040753
lyricists_name: Emmanuel, Anton
lyricists_id: AVEMM74
actors_name: Kalinowski, Damian
actors_id: DKALI47
actors_role: owner
full_text_status: public
publication: Journal of Clinical Medicine
volume: 10
number: 4
article_number: 753
event_location: Switzerland
citation:        Mekhael, M;    Kristensen, HØ;    Larsen, HM;    Juul, T;    Emmanuel, A;    Krogh, K;    Christensen, P;      (2021)    Transanal Irrigation for Neurogenic Bowel Disease, Low Anterior Resection Syndrome, Faecal Incontinence and Chronic Constipation: A Systematic Review.                   Journal of Clinical Medicine , 10  (4)    , Article 753.  10.3390/jcm10040753 <https://doi.org/10.3390/jcm10040753>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10124184/1/Emmanuel_Transanal%20Irrigation%20for%20Neurogenic%20Bowel%20Disease%2C%20Low%20Anterior%20Resection%20Syndrome%2C%20Faecal%20Incontinence%20and%20Chronic%20Constipation_VoR.pdf