eprintid: 10123650
rev_number: 15
eprint_status: archive
userid: 608
dir: disk0/10/12/36/50
datestamp: 2021-03-10 15:40:16
lastmod: 2021-10-04 01:29:13
status_changed: 2021-03-10 15:40:16
type: article
metadata_visibility: show
creators_name: Oettl, L-L
creators_name: Scheller, M
creators_name: Filosa, C
creators_name: Wieland, S
creators_name: Haag, F
creators_name: Loeb, C
creators_name: Durstewitz, D
creators_name: Shusterman, R
creators_name: Russo, E
creators_name: Kelsch, W
title: Phasic dopamine reinforces distinct striatal stimulus encoding in the olfactory tubercle driving dopaminergic reward prediction
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D75
keywords: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, VENTRAL STRIATUM, NEURONS, REPRESENTATIONS, UNCERTAINTY, ACTIVATION, SIGNALS, MODELS, ROLES, PSYCHOSIS, BEHAVIOR
note: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: The learning of stimulus-outcome associations allows for predictions about the environment. Ventral striatum and dopaminergic midbrain neurons form a larger network for generating reward prediction signals from sensory cues. Yet, the network plasticity mechanisms to generate predictive signals in these distributed circuits have not been entirely clarified. Also, direct evidence of the underlying interregional assembly formation and information transfer is still missing. Here we show that phasic dopamine is sufficient to reinforce the distinctness of stimulus representations in the ventral striatum even in the absence of reward. Upon such reinforcement, striatal stimulus encoding gives rise to interregional assemblies that drive dopaminergic neurons during stimulus-outcome learning. These assemblies dynamically encode the predicted reward value of conditioned stimuli. Together, our data reveal that ventral striatal and midbrain reward networks form a reinforcing loop to generate reward prediction coding.
date: 2020-07-10
date_type: published
publisher: NATURE PUBLISHING GROUP
official_url: https://doi.org/10.1038/s41467-020-17257-7
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1852031
doi: 10.1038/s41467-020-17257-7
lyricists_name: Oettl, Lars-Lennart
lyricists_id: LOETT99
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Nature Communications
volume: 11
article_number: 3460
pages: 14
issn: 2041-1723
citation:        Oettl, L-L;    Scheller, M;    Filosa, C;    Wieland, S;    Haag, F;    Loeb, C;    Durstewitz, D;             ... Kelsch, W; + view all <#>        Oettl, L-L;  Scheller, M;  Filosa, C;  Wieland, S;  Haag, F;  Loeb, C;  Durstewitz, D;  Shusterman, R;  Russo, E;  Kelsch, W;   - view fewer <#>    (2020)    Phasic dopamine reinforces distinct striatal stimulus encoding in the olfactory tubercle driving dopaminergic reward prediction.                   Nature Communications , 11     , Article 3460.  10.1038/s41467-020-17257-7 <https://doi.org/10.1038/s41467-020-17257-7>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10123650/1/s41467-020-17257-7.pdf