TY - JOUR Y1 - 2021/03// A1 - Chia, R A1 - Sabir, MS A1 - Bandres-Ciga, S A1 - Saez-Atienzar, S A1 - Reynolds, RH A1 - Gustavsson, E A1 - Walton, RL A1 - Ahmed, S A1 - Viollet, C A1 - Ding, J A1 - Makarious, MB A1 - Diez-Fairen, M A1 - Portley, MK A1 - Shah, Z A1 - Abramzon, Y A1 - Hernandez, DG A1 - Blauwendraat, C A1 - Stone, DJ A1 - Eicher, J A1 - Parkkinen, L A1 - Ansorge, O A1 - Clark, L A1 - Honig, LS A1 - Marder, K A1 - Lemstra, A A1 - St George-Hyslop, P A1 - Londos, E A1 - Morgan, K A1 - Lashley, T A1 - Warner, TT A1 - Jaunmuktane, Z A1 - Galasko, D A1 - Santana, I A1 - Tienari, PJ A1 - Myllykangas, L A1 - Oinas, M A1 - Cairns, NJ A1 - Morris, JC A1 - Halliday, GM A1 - Van Deerlin, VM A1 - Trojanowski, JQ A1 - Grassano, M A1 - Calvo, A A1 - Mora, G A1 - Canosa, A A1 - Floris, G A1 - Bohannan, RC A1 - Brett, F A1 - Gan-Or, Z A1 - Geiger, JT A1 - Moore, A A1 - May, P A1 - Krüger, R A1 - Goldstein, DS A1 - Lopez, G A1 - Tayebi, N A1 - Sidransky, E A1 - American Genome Center A1 - Norcliffe-Kaufmann, L A1 - Palma, J-A A1 - Kaufmann, H A1 - Shakkottai, VG A1 - Perkins, M A1 - Newell, KL A1 - Gasser, T A1 - Schulte, C A1 - Landi, F A1 - Salvi, E A1 - Cusi, D A1 - Masliah, E A1 - Kim, RC A1 - Caraway, CA A1 - Monuki, ES A1 - Brunetti, M A1 - Dawson, TM A1 - Rosenthal, LS A1 - Albert, MS A1 - Pletnikova, O A1 - Troncoso, JC A1 - Flanagan, ME A1 - Mao, Q A1 - Bigio, EH A1 - Rodríguez-Rodríguez, E A1 - Infante, J A1 - Lage, C A1 - González-Aramburu, I A1 - Sanchez-Juan, P A1 - Ghetti, B A1 - Keith, J A1 - Black, SE A1 - Masellis, M A1 - Rogaeva, E A1 - Duyckaerts, C A1 - Brice, A A1 - Lesage, S A1 - Xiromerisiou, G A1 - Barrett, MJ A1 - Tilley, BS A1 - Gentleman, S A1 - Logroscino, G A1 - Serrano, GE A1 - Beach, TG A1 - McKeith, IG A1 - Thomas, AJ A1 - Attems, J A1 - Morris, CM A1 - Palmer, L A1 - Love, S A1 - Troakes, C A1 - Al-Sarraj, S A1 - Hodges, AK A1 - Aarsland, D A1 - Klein, G A1 - Kaiser, SM A1 - Woltjer, R A1 - Pastor, P A1 - Bekris, LM A1 - Leverenz, JB A1 - Besser, LM A1 - Kuzma, A A1 - Renton, AE A1 - Goate, A A1 - Bennett, DA A1 - Scherzer, CR A1 - Morris, HR A1 - Ferrari, R A1 - Albani, D A1 - Pickering-Brown, S A1 - Faber, K A1 - Kukull, WA A1 - Morenas-Rodriguez, E A1 - Lleó, A A1 - Fortea, J A1 - Alcolea, D A1 - Clarimon, J A1 - Nalls, MA A1 - Ferrucci, L A1 - Resnick, SM A1 - Tanaka, T A1 - Foroud, TM A1 - Graff-Radford, NR A1 - Wszolek, ZK A1 - Ferman, T A1 - Boeve, BF A1 - Hardy, JA A1 - Topol, EJ A1 - Torkamani, A A1 - Singleton, AB A1 - Ryten, M A1 - Dickson, DW A1 - Chiò, A A1 - Ross, OA A1 - Gibbs, JR A1 - Dalgard, CL A1 - Traynor, BJ A1 - Scholz, SW EP - 30353 UR - https://doi.org/10.1038/s41588-021-00785-3 N1 - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions. SP - 294 ID - discovery10123624 N2 - The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia, and to generate a resource for the scientific community. Genome-wide association analysis identified five independent risk loci, whereas genome-wide gene-aggregation tests implicated mutations in the gene GBA. Genetic risk scores demonstrate that LBD shares risk profiles and pathways with Alzheimer's disease and Parkinson's disease, providing a deeper molecular understanding of the complex genetic architecture of this age-related neurodegenerative condition. AV - public SN - 1546-1718 VL - 53 JF - Nature Genetics TI - Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture ER -