TY  - JOUR
Y1  - 2021/03//
A1  - Chia, R
A1  - Sabir, MS
A1  - Bandres-Ciga, S
A1  - Saez-Atienzar, S
A1  - Reynolds, RH
A1  - Gustavsson, E
A1  - Walton, RL
A1  - Ahmed, S
A1  - Viollet, C
A1  - Ding, J
A1  - Makarious, MB
A1  - Diez-Fairen, M
A1  - Portley, MK
A1  - Shah, Z
A1  - Abramzon, Y
A1  - Hernandez, DG
A1  - Blauwendraat, C
A1  - Stone, DJ
A1  - Eicher, J
A1  - Parkkinen, L
A1  - Ansorge, O
A1  - Clark, L
A1  - Honig, LS
A1  - Marder, K
A1  - Lemstra, A
A1  - St George-Hyslop, P
A1  - Londos, E
A1  - Morgan, K
A1  - Lashley, T
A1  - Warner, TT
A1  - Jaunmuktane, Z
A1  - Galasko, D
A1  - Santana, I
A1  - Tienari, PJ
A1  - Myllykangas, L
A1  - Oinas, M
A1  - Cairns, NJ
A1  - Morris, JC
A1  - Halliday, GM
A1  - Van Deerlin, VM
A1  - Trojanowski, JQ
A1  - Grassano, M
A1  - Calvo, A
A1  - Mora, G
A1  - Canosa, A
A1  - Floris, G
A1  - Bohannan, RC
A1  - Brett, F
A1  - Gan-Or, Z
A1  - Geiger, JT
A1  - Moore, A
A1  - May, P
A1  - Krüger, R
A1  - Goldstein, DS
A1  - Lopez, G
A1  - Tayebi, N
A1  - Sidransky, E
A1  - American Genome Center
A1  - Norcliffe-Kaufmann, L
A1  - Palma, J-A
A1  - Kaufmann, H
A1  - Shakkottai, VG
A1  - Perkins, M
A1  - Newell, KL
A1  - Gasser, T
A1  - Schulte, C
A1  - Landi, F
A1  - Salvi, E
A1  - Cusi, D
A1  - Masliah, E
A1  - Kim, RC
A1  - Caraway, CA
A1  - Monuki, ES
A1  - Brunetti, M
A1  - Dawson, TM
A1  - Rosenthal, LS
A1  - Albert, MS
A1  - Pletnikova, O
A1  - Troncoso, JC
A1  - Flanagan, ME
A1  - Mao, Q
A1  - Bigio, EH
A1  - Rodríguez-Rodríguez, E
A1  - Infante, J
A1  - Lage, C
A1  - González-Aramburu, I
A1  - Sanchez-Juan, P
A1  - Ghetti, B
A1  - Keith, J
A1  - Black, SE
A1  - Masellis, M
A1  - Rogaeva, E
A1  - Duyckaerts, C
A1  - Brice, A
A1  - Lesage, S
A1  - Xiromerisiou, G
A1  - Barrett, MJ
A1  - Tilley, BS
A1  - Gentleman, S
A1  - Logroscino, G
A1  - Serrano, GE
A1  - Beach, TG
A1  - McKeith, IG
A1  - Thomas, AJ
A1  - Attems, J
A1  - Morris, CM
A1  - Palmer, L
A1  - Love, S
A1  - Troakes, C
A1  - Al-Sarraj, S
A1  - Hodges, AK
A1  - Aarsland, D
A1  - Klein, G
A1  - Kaiser, SM
A1  - Woltjer, R
A1  - Pastor, P
A1  - Bekris, LM
A1  - Leverenz, JB
A1  - Besser, LM
A1  - Kuzma, A
A1  - Renton, AE
A1  - Goate, A
A1  - Bennett, DA
A1  - Scherzer, CR
A1  - Morris, HR
A1  - Ferrari, R
A1  - Albani, D
A1  - Pickering-Brown, S
A1  - Faber, K
A1  - Kukull, WA
A1  - Morenas-Rodriguez, E
A1  - Lleó, A
A1  - Fortea, J
A1  - Alcolea, D
A1  - Clarimon, J
A1  - Nalls, MA
A1  - Ferrucci, L
A1  - Resnick, SM
A1  - Tanaka, T
A1  - Foroud, TM
A1  - Graff-Radford, NR
A1  - Wszolek, ZK
A1  - Ferman, T
A1  - Boeve, BF
A1  - Hardy, JA
A1  - Topol, EJ
A1  - Torkamani, A
A1  - Singleton, AB
A1  - Ryten, M
A1  - Dickson, DW
A1  - Chiò, A
A1  - Ross, OA
A1  - Gibbs, JR
A1  - Dalgard, CL
A1  - Traynor, BJ
A1  - Scholz, SW
EP  - 30353
UR  - https://doi.org/10.1038/s41588-021-00785-3
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
SP  - 294
ID  - discovery10123624
N2  - The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia, and to generate a resource for the scientific community. Genome-wide association analysis identified five independent risk loci, whereas genome-wide gene-aggregation tests implicated mutations in the gene GBA. Genetic risk scores demonstrate that LBD shares risk profiles and pathways with Alzheimer's disease and Parkinson's disease, providing a deeper molecular understanding of the complex genetic architecture of this age-related neurodegenerative condition.
AV  - public
SN  - 1546-1718
VL  - 53
JF  - Nature Genetics
TI  - Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture
ER  -