@article{discovery10123558, journal = {Angewandte Chemie International Edition}, title = {Iodide-Mediated Rapid and Sensitive Surface Etching of Gold Nanostars for Biosensing}, year = {2021}, month = {March}, note = {{\copyright} 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).}, abstract = {Iodide-mediated surface etching can tailor the surface plasmon resonance of gold nanostars through etching of the high-energy facets of the nanoparticle protrusions in a rapid and sensitive way. By exploring the underlying mechanisms of this etching and the key parameters influencing it (such as iodide, oxygen, pH, and temperature), we show its potential in a sensitive biosensing system. Horseradish peroxidase-catalyzed oxidation of iodide enables control of the etching of gold nanostars to spherical gold nanoparticles, where the resulting spectral shift in the surface plasmon resonance yields a distinct color change of the solution. We further develop this enzyme-modulated surface etching of gold nanostars into a versatile platform for plasmonic immunoassays, where a high sensitivity is possible by signal amplification via magnetic beads and click chemistry.}, author = {Xianyu, Y and Lin, Y and Chen, Q and Belessiotis, A and Stevens, M and Thomas, M}, url = {https://doi.org/10.1002/anie.202017317}, keywords = {gold nanostars, horseradish peroxidase, iodide, plasmonic immunoassay, surface etching} }