eprintid: 10120628
rev_number: 14
eprint_status: archive
userid: 608
dir: disk0/10/12/06/28
datestamp: 2021-02-05 10:53:39
lastmod: 2022-01-14 23:22:49
status_changed: 2021-02-05 10:53:39
type: article
metadata_visibility: show
creators_name: Valiente, P
creators_name: Trehy, M
creators_name: White, R
creators_name: Nelissen, P
creators_name: Demetriou, J
creators_name: Stanzani, G
creators_name: de la Puerta, B
title: Complications and outcome of cats with congenital extrahepatic portosystemic shunts treated with thin film: Thirty-four cases (2008-2017)
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
keywords: bile acids, feline, seizures, shunt closure, thin film
note: This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. http://creativecommons.org/licenses/by-nc/4.0/
abstract: Background:
Congenital extrahepatic portosystemic shunts (CEHPSS) are rare in cats. Outcome after attenuation of CEHPSS with thin film has been described in a small number of cases.

Objectives:
To describe the clinical presentation, postoperative complications, and outcome of cats treated with thin film to attenuate CEHPSS.

Animals:
Thirty‐four cats with CEHPSS were identified from the database of 3 institutions over 9 years.

Methods:
Retrospective study. Medical records were reviewed to identify cats with a diagnosis of a CEHPSS that underwent surgical attenuation. Congenital extrahepatic portosystemic shunts were suspected from clinical signs, clinicopathologic findings, and diagnostic imaging, and confirmed at exploratory laparotomy. Cats treated with thin film band attenuation were included. Postoperative complications and follow‐up were recorded.

Results:
Complications were recorded in 11 of 34 cats. Deaths related to CEHPSS occurred in 6 of 34; 4 cats did not survive to discharge. Persistent seizures were the cause of death in 4 cats. Seizures were recorded in 8 of 34 cats after surgery; all these cats received preoperative antiepileptic drugs. Serum bile acid concentrations normalized in 25 of 28 of the cats for which data was available. Three cats had persistently increased serum bile acid concentrations and underwent a second exploratory laparotomy. One had a patent shunt, the other 2 had multiple acquired portosystemic shunts. Median follow‐up was 8 months (0.5‐84 months).

Conclusions and Clinical Importance:
Congenital extrahepatic portosystemic shunts attenuation using thin film in cats carries a good short‐ and mid‐term prognosis if they survive the postoperative period. Seizures were the most common cause of death.
date: 2020-01
date_type: published
official_url: https://doi.org/10.1111/jvim.15649
oa_status: green
full_text_type: pub
pmcid: PMC6979105
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1844631
doi: 10.1111/jvim.15649
lyricists_name: Stanzani, Giacomo
lyricists_id: GSTAN08
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Journal of Veterinary Internal Medicine
volume: 34
number: 1
pagerange: 117-124
event_location: United States
citation:        Valiente, P;    Trehy, M;    White, R;    Nelissen, P;    Demetriou, J;    Stanzani, G;    de la Puerta, B;      (2020)    Complications and outcome of cats with congenital extrahepatic portosystemic shunts treated with thin film: Thirty-four cases (2008-2017).                   Journal of Veterinary Internal Medicine , 34  (1)   pp. 117-124.    10.1111/jvim.15649 <https://doi.org/10.1111/jvim.15649>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10120628/1/jvim.15649.pdf