<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10119873> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/dc/terms/title> "Autologous stem cell transplantation vs bortezomib based chemotheraphy for the first‐line treatment of systemic light chain amyloidosis in the UK"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/ontology/bibo/abstract> "OBJECTIVES: The benefit of autologous stem cell transplantation (ASCT) in the treatment of light chain (AL) amyloidosis requires re-evaluation in the modern era. This retrospective case-matched study compares ASCT to bortezomib for the treatment of patients with AL amyloidosis. METHODS: Newly diagnosed patients with AL amyloidosis treated with ASCT or bortezomib between 2001-2018 were identified. Patients were excluded if the time from diagnosis to treatment exceeded 12 months. Patients were matched on a 1:1 basis, using a propensity matched scoring approach. RESULTS: A total of 136 propensity-score matched patients were included (ASCT n= 68, bortezomib n=68). There was no significant difference in overall survival at two years (p=0.908, HR: 0.95, CI:0.41-2.20). For ASCT vs. bortezomib: overall haematological response rate at six months was 90.6% vs. 92.5%; organ response at 12 months: cardiac (70.0% vs. 54%, p>0.999), renal (74% vs.24%, p=0.463)) liver (21% vs. 22%, p=0.048); median progression free survival (50 vs. 42 months p=0.058, HR:0.61, CI:0.37-1.02) and time to next treatment (68 vs. 45 months, p=0.145, HR:0.61, CI:0.31-1.19). More patients required treatment in the bortezomib group compared to ASCT group at 24 months (41 vs. 23, Chi squared p=0.004) and 48 months (57 vs 41, Chi squared p= 0.004). CONCLUSIONS: This small retrospective study suggests that there is no clear survival advantage of ASCT over bortezomib therapy. A prospective randomised controlled trial evaluating ASCT in AL amyloidosis is critically needed."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/dc/terms/date> "2021-04" .
<https://discovery.ucl.ac.uk/id/document/1252113> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/ontology/bibo/volume> "106" .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/ontology/bibo/issue> "4" .
<https://discovery.ucl.ac.uk/id/publication/ext-c08e2722d91dee5cc3b702865a93f9f0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-c08e2722d91dee5cc3b702865a93f9f0> <http://xmlns.com/foaf/0.1/name> "European Journal of Haematology"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-c08e2722d91dee5cc3b702865a93f9f0> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-166b151daa5161b6073b80a5924ea855> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10119873#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10119873#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-166b151daa5161b6073b80a5924ea855> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-003a8cddcb610fdeae4499b249053bab> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10119873#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10119873#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-003a8cddcb610fdeae4499b249053bab> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a5c667d19248bc0771b2fa32c01cc1f7> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10119873#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10119873#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-a5c667d19248bc0771b2fa32c01cc1f7> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-450a2fb1d8af423a712a8df8c101fa00> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10119873#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10119873#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-450a2fb1d8af423a712a8df8c101fa00> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-aa7b5fc1db08b017ffa6df66805f57ff> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10119873#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10119873#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-aa7b5fc1db08b017ffa6df66805f57ff> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-801ac6ce21f86a607f4220f9474d5f57> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10119873#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10119873#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-801ac6ce21f86a607f4220f9474d5f57> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4d123723841b5ed0d19947387a5b0d00> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10119873#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10119873#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-4d123723841b5ed0d19947387a5b0d00> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d0ebbc37175bca960b9f4c41319b188e> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10119873#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10119873#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-d0ebbc37175bca960b9f4c41319b188e> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c04e79e803f91fde2fded1f18481742f> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10119873#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10119873#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-c04e79e803f91fde2fded1f18481742f> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-59a80599d6bab5ce89f9480be7ae45eb> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10119873#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10119873#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-59a80599d6bab5ce89f9480be7ae45eb> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3dd25468ff47dad515c543dcea43034e> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10119873#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10119873#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-3dd25468ff47dad515c543dcea43034e> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fab9bdc11c35a2284bb58dce276fc357> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10119873#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10119873#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-fab9bdc11c35a2284bb58dce276fc357> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1a63893a9c951364bb59ea11b46d8098> .
<https://discovery.ucl.ac.uk/id/eprint/10119873> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10119873#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10119873#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-1a63893a9c951364bb59ea11b46d8098> .
<https://discovery.ucl.ac.uk/id/person/ext-166b151daa5161b6073b80a5924ea855> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-166b151daa5161b6073b80a5924ea855> <http://xmlns.com/foaf/0.1/givenName> "FA"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-166b151daa5161b6073b80a5924ea855> <http://xmlns.com/foaf/0.1/familyName> "Sharpley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-166b151daa5161b6073b80a5924ea855> <http://xmlns.com/foaf/0.1/name> "FA Sharpley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4d123723841b5ed0d19947387a5b0d00> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4d123723841b5ed0d19947387a5b0d00> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4d123723841b5ed0d19947387a5b0d00> <http://xmlns.com/foaf/0.1/familyName> "Martinez De Azcona Naharro"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4d123723841b5ed0d19947387a5b0d00> <http://xmlns.com/foaf/0.1/name> "A Martinez De Azcona Naharro"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3dd25468ff47dad515c543dcea43034e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-3dd25468ff47dad515c543dcea43034e> <http://xmlns.com/foaf/0.1/givenName> "O"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3dd25468ff47dad515c543dcea43034e> <http://xmlns.com/foaf/0.1/familyName> "Cohen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3dd25468ff47dad515c543dcea43034e> <http://xmlns.com/foaf/0.1/name> "O Cohen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fab9bdc11c35a2284bb58dce276fc357> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-fab9bdc11c35a2284bb58dce276fc357> <http://xmlns.com/foaf/0.1/givenName> "PN"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fab9bdc11c35a2284bb58dce276fc357> <http://xmlns.com/foaf/0.1/familyName> "Hawkins"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fab9bdc11c35a2284bb58dce276fc357> <http://xmlns.com/foaf/0.1/name> "PN Hawkins"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a5c667d19248bc0771b2fa32c01cc1f7> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a5c667d19248bc0771b2fa32c01cc1f7> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a5c667d19248bc0771b2fa32c01cc1f7> <http://xmlns.com/foaf/0.1/familyName> "Petrie"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a5c667d19248bc0771b2fa32c01cc1f7> <http://xmlns.com/foaf/0.1/name> "A Petrie"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-450a2fb1d8af423a712a8df8c101fa00> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-450a2fb1d8af423a712a8df8c101fa00> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-450a2fb1d8af423a712a8df8c101fa00> <http://xmlns.com/foaf/0.1/familyName> "Mahmood"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-450a2fb1d8af423a712a8df8c101fa00> <http://xmlns.com/foaf/0.1/name> "S Mahmood"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-003a8cddcb610fdeae4499b249053bab> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-003a8cddcb610fdeae4499b249053bab> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-003a8cddcb610fdeae4499b249053bab> <http://xmlns.com/foaf/0.1/familyName> "Manwani"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-003a8cddcb610fdeae4499b249053bab> <http://xmlns.com/foaf/0.1/name> "R Manwani"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c04e79e803f91fde2fded1f18481742f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c04e79e803f91fde2fded1f18481742f> <http://xmlns.com/foaf/0.1/givenName> "CJ"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c04e79e803f91fde2fded1f18481742f> <http://xmlns.com/foaf/0.1/familyName> "Whelan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c04e79e803f91fde2fded1f18481742f> <http://xmlns.com/foaf/0.1/name> "CJ Whelan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-801ac6ce21f86a607f4220f9474d5f57> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-801ac6ce21f86a607f4220f9474d5f57> <http://xmlns.com/foaf/0.1/givenName> "HJ"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-801ac6ce21f86a607f4220f9474d5f57> <http://xmlns.com/foaf/0.1/familyName> "Lachmann"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-801ac6ce21f86a607f4220f9474d5f57> <http://xmlns.com/foaf/0.1/name> "HJ Lachmann"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-59a80599d6bab5ce89f9480be7ae45eb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-59a80599d6bab5ce89f9480be7ae45eb> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-59a80599d6bab5ce89f9480be7ae45eb> <http://xmlns.com/foaf/0.1/familyName> "Fontana"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-59a80599d6bab5ce89f9480be7ae45eb> <http://xmlns.com/foaf/0.1/name> "M Fontana"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1a63893a9c951364bb59ea11b46d8098> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1a63893a9c951364bb59ea11b46d8098> <http://xmlns.com/foaf/0.1/givenName> "AD"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1a63893a9c951364bb59ea11b46d8098> <http://xmlns.com/foaf/0.1/familyName> "Wechalekar"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1a63893a9c951364bb59ea11b46d8098> <http://xmlns.com/foaf/0.1/name> "AD Wechalekar"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-aa7b5fc1db08b017ffa6df66805f57ff> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-aa7b5fc1db08b017ffa6df66805f57ff> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-aa7b5fc1db08b017ffa6df66805f57ff> <http://xmlns.com/foaf/0.1/familyName> "Sachchithanantham"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-aa7b5fc1db08b017ffa6df66805f57ff> <http://xmlns.com/foaf/0.1/name> "S Sachchithanantham"^^<http://www.w3.org/2001/XMLSchema#string> .
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