eprintid: 10119815
rev_number: 14
eprint_status: archive
userid: 608
dir: disk0/10/11/98/15
datestamp: 2021-01-28 12:43:25
lastmod: 2021-09-20 22:36:41
status_changed: 2021-01-28 12:43:25
type: article
metadata_visibility: show
creators_name: Taubenberger, A
creators_name: Baum, B
creators_name: Matthews, HK
title: The Mechanics of Mitotic Cell Rounding
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D77
keywords: mitosis, mitotic rounding, myosin, ezrin, Ect2, actin cortex, osmotic pressure, cell mechanics
note: Copyright © 2020 Taubenberger, Baum and Matthews. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
abstract: When animal cells enter mitosis, they round up to become spherical. This shape change is accompanied by changes in mechanical properties. Multiple studies using different measurement methods have revealed that cell surface tension, intracellular pressure and cortical stiffness increase upon entry into mitosis. These cell-scale, biophysical changes are driven by alterations in the composition and architecture of the contractile acto-myosin cortex together with osmotic swelling and enable a mitotic cell to exert force against the environment. When the ability of cells to round is limited, for example by physical confinement, cells suffer severe defects in spindle assembly and cell division. The requirement to push against the environment to create space for spindle formation is especially important for cells dividing in tissues. Here we summarize the evidence and the tools used to show that cells exert rounding forces in mitosis in vitro and in vivo, review the molecular basis for this force generation and discuss its function for ensuring successful cell division in single cells and for cells dividing in normal or diseased tissues.
date: 2020-08-06
date_type: published
publisher: FRONTIERS MEDIA SA
official_url: https://doi.org/10.3389/fcell.2020.00687
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1812187
doi: 10.3389/fcell.2020.00687
lyricists_name: Matthews, Helen
lyricists_id: HKMAT02
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Frontiers in Cell and Developmental Biology
volume: 8
article_number: 687
pages: 16
citation:        Taubenberger, A;    Baum, B;    Matthews, HK;      (2020)    The Mechanics of Mitotic Cell Rounding.                   Frontiers in Cell and Developmental Biology , 8     , Article 687.  10.3389/fcell.2020.00687 <https://doi.org/10.3389/fcell.2020.00687>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10119815/1/fcell-08-00687.pdf