<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10119398> .
<https://discovery.ucl.ac.uk/id/eprint/10119398> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10119398> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10119398> <http://purl.org/dc/terms/title> "Association between polygenic risk score of Alzheimer’s disease and plasma phosphorylated tau in individuals from the Alzheimer’s Disease Neuroimaging Initiative"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10119398> <http://purl.org/ontology/bibo/abstract> "BACKGROUND:\r\nRecent studies suggest that plasma phosphorylated tau181 (p-tau181) is a highly specific biomarker for Alzheimer’s disease (AD)-related tau pathology. It has great potential for the diagnostic and prognostic evaluation of AD, since it identifies AD with the same accuracy as tau PET and CSF p-tau181 and predicts the development of AD dementia in cognitively unimpaired (CU) individuals and in those with mild cognitive impairment (MCI). Plasma p-tau181 may also be used as a biomarker in studies exploring disease pathogenesis, such as genetic or environmental risk factors for AD-type tau pathology. The aim of the present study was to investigate the relation between polygenic risk scores (PRSs) for AD and plasma p-tau181.\r\n\r\nMETHODS:\r\nData from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) was used to examine the relation between AD PRSs, constructed based on findings in recent genome-wide association studies, and plasma p-tau181, using linear regression models. Analyses were performed in the total sample (n = 818), after stratification on diagnostic status (CU (n = 236), MCI (n = 434), AD dementia (n = 148)), and after stratification on Aβ pathology status (Aβ positives (n = 322), Aβ negatives (n = 409)).\r\n\r\nRESULTS:\r\nAssociations between plasma p-tau181 and APOE PRSs (p = 3e−18–7e−15) and non-APOE PRSs (p = 3e−4–0.03) were seen in the total sample. The APOE PRSs were associated with plasma p-tau181 in all diagnostic groups (CU, MCI, and AD dementia), while the non-APOE PRSs were associated only in the MCI group. The APOE PRSs showed similar results in amyloid-β (Aβ)-positive and negative individuals (p = 5e−5–1e−3), while the non-APOE PRSs were associated with plasma p-tau181 in Aβ positives only (p = 0.02).\r\n\r\n\r\nCONCLUSIONS:\r\nPolygenic risk for AD including APOE was found to associate with plasma p-tau181 independent of diagnostic and Aβ pathology status, while polygenic risk for AD beyond APOE was associated with plasma p-tau181 only in MCI and Aβ-positive individuals. These results extend the knowledge about the relation between genetic risk for AD and p-tau181, and further support the usefulness of plasma p-tau181 as a biomarker of AD."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10119398> <http://purl.org/dc/terms/date> "2021-01-08" .
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<https://discovery.ucl.ac.uk/id/eprint/10119398> <http://purl.org/ontology/bibo/volume> "13" .
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<https://discovery.ucl.ac.uk/id/eprint/10119398> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d83b46026d38f5a7e50a8c4116315939> .
<https://discovery.ucl.ac.uk/id/eprint/10119398> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10119398#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10119398> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5057b0e8607da754dd0479117f4fa406> .
<https://discovery.ucl.ac.uk/id/eprint/10119398> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10119398#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10119398#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-5057b0e8607da754dd0479117f4fa406> .
<https://discovery.ucl.ac.uk/id/eprint/10119398> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e6ff11017398bd76f66a6f5f52d49654> .
<https://discovery.ucl.ac.uk/id/eprint/10119398> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10119398#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10119398> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4d284c6d8a2b1044d846ff9289307ea8> .
<https://discovery.ucl.ac.uk/id/eprint/10119398> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10119398#authors> .
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<https://discovery.ucl.ac.uk/id/person/ext-5057b0e8607da754dd0479117f4fa406> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5057b0e8607da754dd0479117f4fa406> <http://xmlns.com/foaf/0.1/givenName> "P"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5057b0e8607da754dd0479117f4fa406> <http://xmlns.com/foaf/0.1/familyName> "Proitsi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5057b0e8607da754dd0479117f4fa406> <http://xmlns.com/foaf/0.1/name> "P Proitsi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6edc93f52fb67ce4c293bfcb98237281> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-6edc93f52fb67ce4c293bfcb98237281> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6edc93f52fb67ce4c293bfcb98237281> <http://xmlns.com/foaf/0.1/familyName> "Zettergren"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6edc93f52fb67ce4c293bfcb98237281> <http://xmlns.com/foaf/0.1/name> "A Zettergren"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7cd76074296a27777727df424e28e255> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7cd76074296a27777727df424e28e255> <http://xmlns.com/foaf/0.1/givenName> "AL"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7cd76074296a27777727df424e28e255> <http://xmlns.com/foaf/0.1/familyName> "Benedet"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7cd76074296a27777727df424e28e255> <http://xmlns.com/foaf/0.1/name> "AL Benedet"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4d284c6d8a2b1044d846ff9289307ea8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4d284c6d8a2b1044d846ff9289307ea8> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4d284c6d8a2b1044d846ff9289307ea8> <http://xmlns.com/foaf/0.1/familyName> "Blennow"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4d284c6d8a2b1044d846ff9289307ea8> <http://xmlns.com/foaf/0.1/name> "K Blennow"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f23a681a82cbcc2b9820402b4079ec07> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-f23a681a82cbcc2b9820402b4079ec07> <http://xmlns.com/foaf/0.1/givenName> "NJ"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f23a681a82cbcc2b9820402b4079ec07> <http://xmlns.com/foaf/0.1/familyName> "Ashton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f23a681a82cbcc2b9820402b4079ec07> <http://xmlns.com/foaf/0.1/name> "NJ Ashton"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/person/ext-d83b46026d38f5a7e50a8c4116315939> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d83b46026d38f5a7e50a8c4116315939> <http://xmlns.com/foaf/0.1/familyName> "Suárez-Calvet"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d83b46026d38f5a7e50a8c4116315939> <http://xmlns.com/foaf/0.1/name> "M Suárez-Calvet"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c2ee229e2aab5fe0161a501f33dd67bf> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c2ee229e2aab5fe0161a501f33dd67bf> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c2ee229e2aab5fe0161a501f33dd67bf> <http://xmlns.com/foaf/0.1/familyName> "Lantero Rodriguez"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c2ee229e2aab5fe0161a501f33dd67bf> <http://xmlns.com/foaf/0.1/name> "J Lantero Rodriguez"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/person/ext-b2556f9884688f7e08afc095c7bea42d> <http://xmlns.com/foaf/0.1/familyName> "Lord"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b2556f9884688f7e08afc095c7bea42d> <http://xmlns.com/foaf/0.1/name> "J Lord"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/person/ext-f5df9705893a9847574171a247f93f05> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f5df9705893a9847574171a247f93f05> <http://xmlns.com/foaf/0.1/familyName> "Snellman"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f5df9705893a9847574171a247f93f05> <http://xmlns.com/foaf/0.1/name> "A Snellman"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e6ff11017398bd76f66a6f5f52d49654> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e6ff11017398bd76f66a6f5f52d49654> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e6ff11017398bd76f66a6f5f52d49654> <http://xmlns.com/foaf/0.1/familyName> "Zetterberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e6ff11017398bd76f66a6f5f52d49654> <http://xmlns.com/foaf/0.1/name> "H Zetterberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-15ecde176b183ffcec2ed9b6c24b47c6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-15ecde176b183ffcec2ed9b6c24b47c6> <http://xmlns.com/foaf/0.1/givenName> "TK"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-15ecde176b183ffcec2ed9b6c24b47c6> <http://xmlns.com/foaf/0.1/familyName> "Karikari"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-15ecde176b183ffcec2ed9b6c24b47c6> <http://xmlns.com/foaf/0.1/name> "TK Karikari"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/eprint/10119398> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> .
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<https://discovery.ucl.ac.uk/id/document/1248422> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1248422> <http://www.w3.org/2000/01/rdf-schema#label> "Association between polygenic risk score of Alzheimer’s disease and plasma phosphorylated tau in individuals from the Alzheimer’s Disease Neuroimaging Initiative (Text)"^^<http://www.w3.org/2001/XMLSchema#string> .
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