eprintid: 10119378 rev_number: 22 eprint_status: archive userid: 608 dir: disk0/10/11/93/78 datestamp: 2021-01-20 11:33:25 lastmod: 2022-08-18 09:02:51 status_changed: 2021-01-20 11:33:25 type: article metadata_visibility: show creators_name: Pemberton, HG creators_name: Goodkin, O creators_name: Prados, F creators_name: Das, RK creators_name: Vos, SB creators_name: Moggridge, J creators_name: Coath, W creators_name: Gordon, E creators_name: Barrett, R creators_name: Schmitt, A creators_name: Whiteley-Jones, H creators_name: Burd, C creators_name: Wattjes, MP creators_name: Haller, S creators_name: Vernooij, MW creators_name: Harper, L creators_name: Fox, NC creators_name: Paterson, RW creators_name: Schott, JM creators_name: Bisdas, S creators_name: White, M creators_name: Ourselin, S creators_name: Thornton, JS creators_name: Yousry, TA creators_name: Cardoso, MJ creators_name: Barkhof, F creators_name: Alzheimer’s Disease Neuroimaging Initiative, title: Automated quantitative MRI volumetry reports support diagnostic interpretation in dementia: a multi-rater, clinical accuracy study ispublished: inpress subjects: UCH divisions: UCL divisions: B02 divisions: C07 divisions: D05 divisions: F66 divisions: D07 divisions: F82 divisions: F86 divisions: B04 divisions: C05 divisions: F48 divisions: F42 keywords: Alzheimer’s disease, Atrophy, Frontotemporal dementia, Magnetic resonance imaging, Radiologists note: Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. abstract: OBJECTIVES: We examined whether providing a quantitative report (QReport) of regional brain volumes improves radiologists' accuracy and confidence in detecting volume loss, and in differentiating Alzheimer's disease (AD) and frontotemporal dementia (FTD), compared with visual assessment alone. METHODS: Our forced-choice multi-rater clinical accuracy study used MRI from 16 AD patients, 14 FTD patients, and 15 healthy controls; age range 52-81. Our QReport was presented to raters with regional grey matter volumes plotted as percentiles against data from a normative population (n = 461). Nine raters with varying radiological experience (3 each: consultants, registrars, 'non-clinical image analysts') assessed each case twice (with and without the QReport). Raters were blinded to clinical and demographic information; they classified scans as 'normal' or 'abnormal' and if 'abnormal' as 'AD' or 'FTD'. RESULTS: The QReport improved sensitivity for detecting volume loss and AD across all raters combined (p = 0.015* and p = 0.002*, respectively). Only the consultant group's accuracy increased significantly when using the QReport (p = 0.02*). Overall, raters' agreement (Cohen's κ) with the 'gold standard' was not significantly affected by the QReport; only the consultant group improved significantly (κs 0.41➔0.55, p = 0.04*). Cronbach's alpha for interrater agreement improved from 0.886 to 0.925, corresponding to an improvement from 'good' to 'excellent'. CONCLUSION: Our QReport referencing single-subject results to normative data alongside visual assessment improved sensitivity, accuracy, and interrater agreement for detecting volume loss. The QReport was most effective in the consultants, suggesting that experience is needed to fully benefit from the additional information provided by quantitative analyses. KEY POINTS: • The use of quantitative report alongside routine visual MRI assessment improves sensitivity and accuracy for detecting volume loss and AD vs visual assessment alone. • Consultant neuroradiologists' assessment accuracy and agreement (kappa scores) significantly improved with the use of quantitative atrophy reports. • First multi-rater radiological clinical evaluation of visual quantitative MRI atrophy report for use as a diagnostic aid in dementia. date: 2021-01-15 date_type: published official_url: http://dx.doi.org/10.1007/s00330-020-07455-8 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1842418 doi: 10.1007/s00330-020-07455-8 pii: 10.1007/s00330-020-07455-8 lyricists_name: Barkhof, Frederik lyricists_name: Bisdas, Sotirios lyricists_name: Cardoso, Manuel lyricists_name: Coath, William lyricists_name: Das, Ravi lyricists_name: Fox, Nicholas lyricists_name: Goodkin, Olivia lyricists_name: Paterson, Ross lyricists_name: Pemberton, Hugh lyricists_name: Prados Carrasco, Ferran lyricists_name: Schott, Jonathan lyricists_name: Thornton, John lyricists_name: Vos, Sjoerd lyricists_name: Yousry, Tarek lyricists_id: FBARK32 lyricists_id: SBISD53 lyricists_id: MJMCA47 lyricists_id: WOCOA32 lyricists_id: RDASX57 lyricists_id: NCIFO25 lyricists_id: OGOOD06 lyricists_id: RPATA12 lyricists_id: HGBPE46 lyricists_id: FPRAD65 lyricists_id: JMSCH12 lyricists_id: JSTHO11 lyricists_id: SVOSX19 lyricists_id: TAYOU67 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: European Radiology event_location: Germany citation: Pemberton, HG; Goodkin, O; Prados, F; Das, RK; Vos, SB; Moggridge, J; Coath, W; ... Alzheimer’s Disease Neuroimaging Initiative; + view all <#> Pemberton, HG; Goodkin, O; Prados, F; Das, RK; Vos, SB; Moggridge, J; Coath, W; Gordon, E; Barrett, R; Schmitt, A; Whiteley-Jones, H; Burd, C; Wattjes, MP; Haller, S; Vernooij, MW; Harper, L; Fox, NC; Paterson, RW; Schott, JM; Bisdas, S; White, M; Ourselin, S; Thornton, JS; Yousry, TA; Cardoso, MJ; Barkhof, F; Alzheimer’s Disease Neuroimaging Initiative; - view fewer <#> (2021) Automated quantitative MRI volumetry reports support diagnostic interpretation in dementia: a multi-rater, clinical accuracy study. European Radiology 10.1007/s00330-020-07455-8 <https://doi.org/10.1007/s00330-020-07455-8>. (In press). Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10119378/1/Pemberton2021_Article_AutomatedQuantitativeMRIVolume.pdf