eprintid: 10118876
rev_number: 20
eprint_status: archive
userid: 608
dir: disk0/10/11/88/76
datestamp: 2021-01-20 11:27:30
lastmod: 2022-02-14 14:50:36
status_changed: 2021-01-20 11:27:30
type: article
metadata_visibility: show
creators_name: Austin, K
creators_name: Lee, BJ
creators_name: Flood, TR
creators_name: Toombs, J
creators_name: Borisova, M
creators_name: Lauder, M
creators_name: Heslegrave, A
creators_name: Zetterberg, H
creators_name: Smith, NA
title: Serum neurofilament light concentration does not increase following exposure to low velocity football heading
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F86
keywords: Soccer, heading, brain injury, axonal damage, biomechanics
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
abstract: OBJECTIVES: To investigate if heading frequency and impact biomechanics in a single session influence the concentration of serum neurofilament light (NF-L), a sensitive biomarker for axonal damage, up to 7 days after heading incident at ball velocities reflecting basic training drills. METHODS: Forty-four males were randomized into either control (n = 8), 10 header (n = 12), 20 header (n = 12) or 40 header (n = 12) groups. Linear and angular head accelerations were quantified during heading. Venous blood samples were taken at baseline, 6 h, 24 h and 7 days after heading. Serum NF-L was quantified using Quanterix NF-L assay kit on the Simoa HD-1 Platform. RESULTS: erum NF-L did not alter over time (p = 0.44) and was not influenced by number of headers [p = 0.47; mean (95% CI) concentrations at baseline 6.00 pg · ml^{− 1} (5.00–7.00 pg · ml^{− 1}); 6 h post 6.50 pg · ml^{− 1} (5.70–7.29 pg · ml^{− 1}); 24 h post 6.07 pg · ml^{− 1} (5.14–7.01 pg · ml^{− 1}); and 7 days post 6.46 pg · ml^{− 1} (5.45–7.46 pg · ml^{− 1})]. There was no relationship between percentage change in NF-L and summed session linear and angular head accelerations. CONCLUSION: In adult men, heading frequency or impact biomechanics did not affect NF-L response during a single session of headers at ball velocities reflective of basic training tasks.
date: 2021
date_type: published
publisher: TAYLOR & FRANCIS LTD
official_url: https://doi.org/10.1080/24733938.2020.1853210
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1831096
doi: 10.1080/24733938.2020.1853210
lyricists_name: Heslegrave, Amanda
lyricists_name: Zetterberg, Henrik
lyricists_id: AJHES09
lyricists_id: HZETT94
actors_name: Zetterberg, Henrik
actors_name: Harriot, Anne-Marie
actors_id: HZETT94
actors_id: AHARA72
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: Science and Medicine in Football
volume: 5
number: 3
pagerange: 188-194
pages: 7
citation:        Austin, K;    Lee, BJ;    Flood, TR;    Toombs, J;    Borisova, M;    Lauder, M;    Heslegrave, A;         ... Smith, NA; + view all <#>        Austin, K;  Lee, BJ;  Flood, TR;  Toombs, J;  Borisova, M;  Lauder, M;  Heslegrave, A;  Zetterberg, H;  Smith, NA;   - view fewer <#>    (2021)    Serum neurofilament light concentration does not increase following exposure to low velocity football heading.                   Science and Medicine in Football , 5  (3)   pp. 188-194.    10.1080/24733938.2020.1853210 <https://doi.org/10.1080/24733938.2020.1853210>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10118876/3/Zetterberg_Serum%20neurofilament%20light%20concentration%20does%20not%20increase%20following%20exposure%20to%20low%20velocity%20football%20heading_AAM.pdf