eprintid: 10118876 rev_number: 20 eprint_status: archive userid: 608 dir: disk0/10/11/88/76 datestamp: 2021-01-20 11:27:30 lastmod: 2022-02-14 14:50:36 status_changed: 2021-01-20 11:27:30 type: article metadata_visibility: show creators_name: Austin, K creators_name: Lee, BJ creators_name: Flood, TR creators_name: Toombs, J creators_name: Borisova, M creators_name: Lauder, M creators_name: Heslegrave, A creators_name: Zetterberg, H creators_name: Smith, NA title: Serum neurofilament light concentration does not increase following exposure to low velocity football heading ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F86 keywords: Soccer, heading, brain injury, axonal damage, biomechanics note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. abstract: OBJECTIVES: To investigate if heading frequency and impact biomechanics in a single session influence the concentration of serum neurofilament light (NF-L), a sensitive biomarker for axonal damage, up to 7 days after heading incident at ball velocities reflecting basic training drills. METHODS: Forty-four males were randomized into either control (n = 8), 10 header (n = 12), 20 header (n = 12) or 40 header (n = 12) groups. Linear and angular head accelerations were quantified during heading. Venous blood samples were taken at baseline, 6 h, 24 h and 7 days after heading. Serum NF-L was quantified using Quanterix NF-L assay kit on the Simoa HD-1 Platform. RESULTS: erum NF-L did not alter over time (p = 0.44) and was not influenced by number of headers [p = 0.47; mean (95% CI) concentrations at baseline 6.00 pg · ml^{− 1} (5.00–7.00 pg · ml^{− 1}); 6 h post 6.50 pg · ml^{− 1} (5.70–7.29 pg · ml^{− 1}); 24 h post 6.07 pg · ml^{− 1} (5.14–7.01 pg · ml^{− 1}); and 7 days post 6.46 pg · ml^{− 1} (5.45–7.46 pg · ml^{− 1})]. There was no relationship between percentage change in NF-L and summed session linear and angular head accelerations. CONCLUSION: In adult men, heading frequency or impact biomechanics did not affect NF-L response during a single session of headers at ball velocities reflective of basic training tasks. date: 2021 date_type: published publisher: TAYLOR & FRANCIS LTD official_url: https://doi.org/10.1080/24733938.2020.1853210 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1831096 doi: 10.1080/24733938.2020.1853210 lyricists_name: Heslegrave, Amanda lyricists_name: Zetterberg, Henrik lyricists_id: AJHES09 lyricists_id: HZETT94 actors_name: Zetterberg, Henrik actors_name: Harriot, Anne-Marie actors_id: HZETT94 actors_id: AHARA72 actors_role: owner actors_role: impersonator full_text_status: public publication: Science and Medicine in Football volume: 5 number: 3 pagerange: 188-194 pages: 7 citation: Austin, K; Lee, BJ; Flood, TR; Toombs, J; Borisova, M; Lauder, M; Heslegrave, A; ... Smith, NA; + view all <#> Austin, K; Lee, BJ; Flood, TR; Toombs, J; Borisova, M; Lauder, M; Heslegrave, A; Zetterberg, H; Smith, NA; - view fewer <#> (2021) Serum neurofilament light concentration does not increase following exposure to low velocity football heading. Science and Medicine in Football , 5 (3) pp. 188-194. 10.1080/24733938.2020.1853210 <https://doi.org/10.1080/24733938.2020.1853210>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10118876/3/Zetterberg_Serum%20neurofilament%20light%20concentration%20does%20not%20increase%20following%20exposure%20to%20low%20velocity%20football%20heading_AAM.pdf