TY  - JOUR
VL  - 5
Y1  - 2021///
TI  - Serum neurofilament light concentration does not increase following exposure to low velocity football heading
IS  - 3
KW  - Soccer
KW  -  heading
KW  -  brain injury
KW  -  axonal damage
KW  -  biomechanics
A1  - Austin, K
A1  - Lee, BJ
A1  - Flood, TR
A1  - Toombs, J
A1  - Borisova, M
A1  - Lauder, M
A1  - Heslegrave, A
A1  - Zetterberg, H
A1  - Smith, NA
EP  - 194
JF  - Science and Medicine in Football
PB  - TAYLOR & FRANCIS LTD
UR  - https://doi.org/10.1080/24733938.2020.1853210
ID  - discovery10118876
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
AV  - public
N2  - OBJECTIVES: To investigate if heading frequency and impact biomechanics in a single session influence the concentration of serum neurofilament light (NF-L), a sensitive biomarker for axonal damage, up to 7 days after heading incident at ball velocities reflecting basic training drills. METHODS: Forty-four males were randomized into either control (n = 8), 10 header (n = 12), 20 header (n = 12) or 40 header (n = 12) groups. Linear and angular head accelerations were quantified during heading. Venous blood samples were taken at baseline, 6 h, 24 h and 7 days after heading. Serum NF-L was quantified using Quanterix NF-L assay kit on the Simoa HD-1 Platform. RESULTS: erum NF-L did not alter over time (p = 0.44) and was not influenced by number of headers [p = 0.47; mean (95% CI) concentrations at baseline 6.00 pg · ml^{? 1} (5.00?7.00 pg · ml^{? 1}); 6 h post 6.50 pg · ml^{? 1} (5.70?7.29 pg · ml^{? 1}); 24 h post 6.07 pg · ml^{? 1} (5.14?7.01 pg · ml^{? 1}); and 7 days post 6.46 pg · ml^{? 1} (5.45?7.46 pg · ml^{? 1})]. There was no relationship between percentage change in NF-L and summed session linear and angular head accelerations. CONCLUSION: In adult men, heading frequency or impact biomechanics did not affect NF-L response during a single session of headers at ball velocities reflective of basic training tasks.
SP  - 188
ER  -