@article{discovery10118876,
            year = {2021},
          volume = {5},
          number = {3},
           title = {Serum neurofilament light concentration does not increase following exposure to low velocity football heading},
            note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.},
       publisher = {TAYLOR \& FRANCIS LTD},
         journal = {Science and Medicine in Football},
           pages = {188--194},
        abstract = {OBJECTIVES: To investigate if heading frequency and impact biomechanics in a single session influence the concentration of serum neurofilament light (NF-L), a sensitive biomarker for axonal damage, up to 7 days after heading incident at ball velocities reflecting basic training drills. METHODS: Forty-four males were randomized into either control (n = 8), 10 header (n = 12), 20 header (n = 12) or 40 header (n = 12) groups. Linear and angular head accelerations were quantified during heading. Venous blood samples were taken at baseline, 6 h, 24 h and 7 days after heading. Serum NF-L was quantified using Quanterix NF-L assay kit on the Simoa HD-1 Platform. RESULTS: erum NF-L did not alter over time (p = 0.44) and was not influenced by number of headers [p = 0.47; mean (95\% CI) concentrations at baseline 6.00 pg . ml{\^{ }}\{? 1\} (5.00-7.00 pg . ml{\^{ }}\{? 1\}); 6 h post 6.50 pg . ml{\^{ }}\{? 1\} (5.70-7.29 pg . ml{\^{ }}\{? 1\}); 24 h post 6.07 pg . ml{\^{ }}\{? 1\} (5.14-7.01 pg . ml{\^{ }}\{? 1\}); and 7 days post 6.46 pg . ml{\^{ }}\{? 1\} (5.45-7.46 pg . ml{\^{ }}\{? 1\})]. There was no relationship between percentage change in NF-L and summed session linear and angular head accelerations. CONCLUSION: In adult men, heading frequency or impact biomechanics did not affect NF-L response during a single session of headers at ball velocities reflective of basic training tasks.},
             url = {https://doi.org/10.1080/24733938.2020.1853210},
          author = {Austin, K and Lee, BJ and Flood, TR and Toombs, J and Borisova, M and Lauder, M and Heslegrave, A and Zetterberg, H and Smith, NA},
        keywords = {Soccer, heading, brain injury, axonal damage, biomechanics}
}