<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10118844> . <https://discovery.ucl.ac.uk/id/eprint/10118844> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10118844> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10118844> <http://purl.org/dc/terms/title> "Redox Regulation of Microvascular Permeability: IL-1β Potentiation of Bradykinin-Induced Permeability Is Prevented by Simvastatin"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10118844> <http://purl.org/ontology/bibo/abstract> "Antioxidant effects of statins have been implicated in the reduction in microvascular permeability and edema formation in experimental and clinical studies. Bradykinin (Bk)-induced increases in microvascular permeability are potentiated by IL-1β; however, no studies have examined the protection afforded by statins against microvascular hyperpermeability. We investigated the effects of simvastatin pretreatment on albumin-fluorescein isothiocyanate conjugate (FITC-albumin) permeability in post-capillary venules in rat cremaster muscle. Inhibition of nitric oxide synthase with L-NAME (10µM) increased basal permeability to FITC-albumin, which was abrogated by superoxide dismutase and catalase. Histamine-induced (1 µM) permeability was blocked by L-NAME but unaffected by scavenging reactive oxygen species with superoxide dismutase (SOD) and catalase. In contrast, bradykinin-induced (1-100 nM) permeability increases were unaffected by L-NAME but abrogated by SOD and catalase. Acute superfusion of the cremaster muscle with IL-1β (30 pM, 10 min) resulted in a leftward shift of the bradykinin concentration-response curve. Potentiation by IL-1β of bradykinin-induced microvascular permeability was prevented by the nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) inhibitor apocynin (1 µM). Pretreatment of rats with simvastatin (5 mg·kg-1, i.p.) 24 h before permeability measurements prevented the potentiation of bradykinin permeability responses by IL-1β, which was not reversed by inhibition of heme oxygenase-1 with tin protoporphyrin IX (SnPP). This study highlights a novel mechanism by which simvastatin prevents the potentiation of bradykinin-induced permeability by IL-1β, possibly by targeting the assembly of NADPH oxidase subunits. Our findings highlight the therapeutic potential of statins in the prevention and treatment of patients predisposed to inflammatory diseases."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10118844> <http://purl.org/dc/terms/date> "2020-12-14" . <https://discovery.ucl.ac.uk/id/document/1243577> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10118844> <http://purl.org/ontology/bibo/volume> "9" . <https://discovery.ucl.ac.uk/id/eprint/10118844> <http://purl.org/ontology/bibo/issue> "12" . <https://discovery.ucl.ac.uk/id/publication/ext-87985daf9dd414518d57e759c397df90> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-87985daf9dd414518d57e759c397df90> <http://xmlns.com/foaf/0.1/name> "Antioxidants"^^<http://www.w3.org/2001/XMLSchema#string> . 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<https://discovery.ucl.ac.uk/id/eprint/10118844> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10118844#authors> . <https://discovery.ucl.ac.uk/id/eprint/10118844#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-82a2ef1576ac8828f205f8550d0c26e5> . <https://discovery.ucl.ac.uk/id/eprint/10118844> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-06b34f76853bab123162b95e97eb0d5f> . <https://discovery.ucl.ac.uk/id/eprint/10118844> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10118844#authors> . <https://discovery.ucl.ac.uk/id/eprint/10118844#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-06b34f76853bab123162b95e97eb0d5f> . <https://discovery.ucl.ac.uk/id/person/ext-04bf1f961cf84aa0c6f658750e6a82c6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . 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. <https://discovery.ucl.ac.uk/id/person/ext-d49a42e664e27f536603c4497176ba98> <http://xmlns.com/foaf/0.1/name> "E Tibiriçá"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-82a2ef1576ac8828f205f8550d0c26e5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-82a2ef1576ac8828f205f8550d0c26e5> <http://xmlns.com/foaf/0.1/givenName> "PA"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-82a2ef1576ac8828f205f8550d0c26e5> <http://xmlns.com/foaf/0.1/familyName> "Fraser"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-82a2ef1576ac8828f205f8550d0c26e5> <http://xmlns.com/foaf/0.1/name> "PA Fraser"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9d2a440600d3afa2f77413ae8096d977> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-9d2a440600d3afa2f77413ae8096d977> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9d2a440600d3afa2f77413ae8096d977> <http://xmlns.com/foaf/0.1/familyName> "Singh"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9d2a440600d3afa2f77413ae8096d977> <http://xmlns.com/foaf/0.1/name> "M Singh"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-06b34f76853bab123162b95e97eb0d5f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-06b34f76853bab123162b95e97eb0d5f> <http://xmlns.com/foaf/0.1/givenName> "GE"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-06b34f76853bab123162b95e97eb0d5f> <http://xmlns.com/foaf/0.1/familyName> "Mann"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-06b34f76853bab123162b95e97eb0d5f> <http://xmlns.com/foaf/0.1/name> "GE Mann"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10118844> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> . <https://discovery.ucl.ac.uk/id/eprint/10118844> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> . <https://discovery.ucl.ac.uk/id/eprint/10118844> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> . <https://discovery.ucl.ac.uk/id/eprint/10118844> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1243577> . <https://discovery.ucl.ac.uk/id/document/1243577> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> . <https://discovery.ucl.ac.uk/id/document/1243577> <http://www.w3.org/2000/01/rdf-schema#label> "Redox Regulation of Microvascular Permeability: IL-1β Potentiation of Bradykinin-Induced Permeability Is Prevented by Simvastatin (Text)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10118844> <http://purl.org/dc/elements/1.1/hasVersion> <https://discovery.ucl.ac.uk/id/document/1243577> . <https://discovery.ucl.ac.uk/id/eprint/10118844> <http://eprints.org/ontology/hasPublished> <https://discovery.ucl.ac.uk/id/document/1243577> . <https://discovery.ucl.ac.uk/id/document/1243577> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10118844/1/antioxidants-09-01269.pdf> . <https://discovery.ucl.ac.uk/id/document/1243577> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10118844/1/antioxidants-09-01269.pdf> . <https://discovery.ucl.ac.uk/id/eprint/10118844/1/antioxidants-09-01269.pdf> <http://www.w3.org/2000/01/rdf-schema#label> "antioxidants-09-01269.pdf"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10118844> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1243578> . <https://discovery.ucl.ac.uk/id/document/1243578> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> . <https://discovery.ucl.ac.uk/id/document/1243578> <http://www.w3.org/2000/01/rdf-schema#label> "Redox Regulation of Microvascular Permeability: IL-1β Potentiation of Bradykinin-Induced Permeability Is Prevented by Simvastatin (Other)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/document/1243578> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1243577> . <https://discovery.ucl.ac.uk/id/document/1243578> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1243577> . <https://discovery.ucl.ac.uk/id/document/1243578> <http://eprints.org/relation/islightboxThumbnailVersionOf> 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