%L discovery10118634
%K glia, nervous system development, neural specification, circuit wiring, circuit function,
neurodevelopmental disorders, neurodegenerative disorders
%X Glial cells are an essential component of the nervous system of vertebrates and
invertebrates. In the human brain, glia are as numerous as neurons, yet the importance
of glia to nearly every aspect of nervous system development has only been expounded
over the last several decades. Glia are now known to regulate neural specification,
synaptogenesis, synapse function, and even broad circuit function. Given their ubiquity,
it is not surprising that the contribution of glia to neuronal disease pathogenesis is a
growing area of research. In this review, we will summarize the accumulated evidence
of glial participation in several distinct phases of nervous system development and
organization—neural specification, circuit wiring, and circuit function. Finally, we will
highlight how these early developmental roles of glia contribute to nervous system
dysfunction in neurodevelopmental and neurodegenerative disorders
%T More Than Mortar: Glia as Architects of Nervous System Development and Disease
%A I Lago-Baldaia
%A VM Fernandes
%A SD Ackerman
%J Frontiers in Cell and Developmental Biology
%D 2020
%O This is an open-access
article distributed under the terms of the Creative Commons Attribution License
(CC BY). The use, distribution or reproduction in other forums is permitted, provided
the original author(s) and the copyright owner(s) are credited and that the original
publication in this journal is cited, in accordance with accepted academic practice. No
use, distribution or reproduction is permitted which does not comply with these terms.
http://creativecommons.org/licenses/by/4.0/
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