eprintid: 10118446
rev_number: 14
eprint_status: archive
userid: 608
dir: disk0/10/11/84/46
datestamp: 2021-01-05 11:56:51
lastmod: 2021-10-09 22:22:51
status_changed: 2021-01-05 11:56:51
type: article
metadata_visibility: show
creators_name: Abouward, R
creators_name: Schiavo, G
title: Walking the line: mechanisms underlying directional mRNA transport and localisation in neurons and beyond
ispublished: inpress
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F85
keywords: Axonal transport · Vesicular trafc · Neurodegeneration
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abstract: Messenger RNA (mRNA) localisation enables a high degree of spatiotemporal control on protein synthesis, which contributes
to establishing the asymmetric protein distribution required to set up and maintain cellular polarity. As such, a tight control
of mRNA localisation is essential for many biological processes during development and in adulthood, such as body axes
determination in Drosophila melanogaster and synaptic plasticity in neurons. The mechanisms controlling how mRNAs are
localised, including difusion and entrapment, local degradation and directed active transport, are largely conserved across
evolution and have been under investigation for decades in diferent biological models. In this review, we will discuss the
standing of the feld regarding directional mRNA transport in light of the recent discovery that RNA can hitchhike on cytoplasmic organelles, such as endolysosomes, and the impact of these transport modalities on our understanding of neuronal
function during development, adulthood and in neurodegeneration
date: 2020-12-20
date_type: published
official_url: https://doi.org/10.1007/s00018-020-03724-3
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1838615
doi: 10.1007/s00018-020-03724-3
pii: 10.1007/s00018-020-03724-3
lyricists_name: Schiavo, Giampietro
lyricists_id: GSCHI71
actors_name: Bracey, Alan
actors_id: ABBRA90
actors_role: owner
full_text_status: public
publication: Cellular and Molecular Life Sciences
event_location: Switzerland
citation:        Abouward, R;    Schiavo, G;      (2020)    Walking the line: mechanisms underlying directional mRNA transport and localisation in neurons and beyond.                   Cellular and Molecular Life Sciences        10.1007/s00018-020-03724-3 <https://doi.org/10.1007/s00018-020-03724-3>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10118446/1/Abouward-Schiavo2020_Article_WalkingTheLineMechanismsUnderl.pdf