eprintid: 10118425
rev_number: 14
eprint_status: archive
userid: 608
dir: disk0/10/11/84/25
datestamp: 2021-01-05 10:50:54
lastmod: 2021-10-09 22:49:33
status_changed: 2021-01-05 10:50:54
type: article
metadata_visibility: show
creators_name: Eagle, DM
creators_name: Schepisi, C
creators_name: Chugh, S
creators_name: Desai, S
creators_name: Han, SYS
creators_name: Huang, T
creators_name: Lee, JJ
creators_name: Sobala, C
creators_name: Ye, W
creators_name: Milton, AL
creators_name: Robbins, TW
title: Dissociable dopaminergic and pavlovian influences in goal-trackers and sign-trackers on a model of compulsive checking in OCD
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
keywords: Obsessive-compulsive disorder . Sign-tracking . Goal-tracking . Quinpirole . Pavlovian . Rat
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abstract: Rationale: Checking is a functional behaviour that provides information to guide behaviour. However, in obsessive-compulsive
disorder (OCD), checking may escalate to dysfunctional levels. The processes underpinning the transition from functional to
dysfunctional checking are unclear but may be associated with individual differences that support the development of maladaptive behaviour. We examined one such predisposition, sign-tracking to a pavlovian conditioned stimulus, which we previously
found associated with dysfunctional checking. How sign-tracking interacts with another treatment with emerging translational
validity for OCD-like checking, chronic administration of the dopamine D2 receptor agonist quinpirole, is unknown.
Objectives: We tested how functional and dysfunctional checking in the rat observing response task (ORT) was affected by
chronic quinpirole administration in non-autoshaped controls and autoshaped animals classified as sign-trackers or goal-trackers.
Methods: Sign-trackers or goal-trackers were trained on the ORT before the effects of chronic quinpirole administration on
checking were assessed. Subsequently, the effects on checking of different behavioural challenges, including reward omission
and the use of unpredictable reinforcement schedules, were tested.
Results: Prior autoshaping increased checking. Sign-trackers and goal-trackers responded differently to quinpirole sensitization,
reward omission and reinforcement uncertainty. Sign-trackers showed greater elevations in dysfunctional checking, particularly
during uncertainty. By contrast, goal-trackers predominantly increased functional checking responses, possibly in response to
reduced discrimination accuracy in the absence of cues signalling which lever was currently active.
Conclusions: The results are discussed in terms of how pavlovian associations influence behaviour that becomes compulsive in
OCD and how this may be dependent on striatal dopamine D2 receptors
date: 2020-12
date_type: published
publisher: SPRINGER
official_url: https://doi.org/10.1007/s00213-020-05636-3
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1813066
doi: 10.1007/s00213-020-05636-3
lyricists_name: Lee, Julie
lyricists_id: JLEEA07
actors_name: Austen, Jennifer
actors_id: JAUST66
actors_role: owner
full_text_status: public
publication: Psychopharmacology
volume: 237
pagerange: 3569-3581
pages: 13
citation:        Eagle, DM;    Schepisi, C;    Chugh, S;    Desai, S;    Han, SYS;    Huang, T;    Lee, JJ;                 ... Robbins, TW; + view all <#>        Eagle, DM;  Schepisi, C;  Chugh, S;  Desai, S;  Han, SYS;  Huang, T;  Lee, JJ;  Sobala, C;  Ye, W;  Milton, AL;  Robbins, TW;   - view fewer <#>    (2020)    Dissociable dopaminergic and pavlovian influences in goal-trackers and sign-trackers on a model of compulsive checking in OCD.                   Psychopharmacology , 237    pp. 3569-3581.    10.1007/s00213-020-05636-3 <https://doi.org/10.1007/s00213-020-05636-3>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10118425/1/Eagle2020_Article_DissociableDopaminergicAndPavl.pdf