TY  - JOUR
ID  - discovery10118253
A1  - Jiang, W
A1  - Luo, Z
A1  - Stephenson, S
A1  - Li, H
A1  - Di Germanio, C
A1  - Norris, PJ
A1  - Fuchs, D
A1  - Zetterberg, H
A1  - Gisslen, M
A1  - Price, RW
VL  - 223
UR  - https://doi.org/10.1093/infdis/jiaa765
N2  - HIV infection is associated with increased systemic microbial translocation, neuro-inflammation and occasionally neuronal injury. Whether systemic LPS penetrates into the brain and contributes to neuro-inflammation remain unknown in HIV. Here, we measured plasma and cerebrospinal fluid (CSF) LPS levels along with biomarkers of neuro-inflammation (white blood cell counts and 40 soluble markers) and neurofilament light chain (NfL). Notably, CSF LPS was undetectable in all samples, including three HIV-infected individuals with dementia. Increased plasma LPS, neuro-inflammation, and blood-brain barrier (BBB) dysfunction were found in untreated HIV-infected individuals, but not in healthy or treated HIV-infected individuals. Plasma LPS levels were directly correlated with various markers of inflammation in both plasma and CSF, as well as with degree of BBB permeability but not with CSF NfL in HIV-infected subjects. These results suggest that the magnitude of microbial translocation associates with neuro-inflammation and BBB permeability in HIV without direct penetration into the central nervous system (CNS).
EP  - 1620
TI  - Cerebrospinal fluid and plasma lipopolysaccharide (LPS) levels in HIV-1 infection and associations with inflammation, blood-brain barrier permeability and neuronal injury
Y1  - 2021/05/01/
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
KW  - Cerebrospinal fluid
KW  -  HIV-1 infection
KW  -  blood-brain barrier permeability
KW  -  lipopolysaccharide
KW  -  neuroinflammation
KW  -  neuronal injury
IS  - 9
AV  - public
JF  - Journal of Infectious Diseases
SN  - 1537-6613
SP  - 1612
ER  -