eprintid: 10117834
rev_number: 14
eprint_status: archive
userid: 608
dir: disk0/10/11/78/34
datestamp: 2020-12-18 09:58:23
lastmod: 2021-09-19 23:19:00
status_changed: 2020-12-18 09:58:23
type: article
metadata_visibility: show
creators_name: Bjedov, I
creators_name: Rallis, C
title: The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: B04
divisions: C05
divisions: F42
keywords: ageing, Drosophila, yeast, nutrient-response, autophagy, translation, transcription, metabolism, TORC1, TORC2, MESSENGER-RNA TRANSLATION, AMINO-ACID CONTROL, GENE-EXPRESSION, S6 KINASE, TRANSCRIPTION FACTORS, INSULIN-RESISTANCE, STRESS RESISTANCE, INDUCED OBESITY, POLYMERASE III, CELL-GROWTH
note: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
abstract: Ageing is a complex trait controlled by genes and the environment. The highly conserved mechanistic target of rapamycin signalling pathway (mTOR) is a major regulator of lifespan in all eukaryotes and is thought to be mediating some of the effects of dietary restriction. mTOR is a rheostat of energy sensing diverse inputs such as amino acids, oxygen, hormones, and stress and regulates lifespan by tuning cellular functions such as gene expression, ribosome biogenesis, proteostasis, and mitochondrial metabolism. Deregulation of the mTOR signalling pathway is implicated in multiple age-related diseases such as cancer, neurodegeneration, and auto-immunity. In this review, we briefly summarise some of the workings of mTOR in lifespan and ageing through the processes of transcription, translation, autophagy, and metabolism. A good understanding of the pathway’s outputs and connectivity is paramount towards our ability for genetic and pharmacological interventions for healthy ageing and amelioration of age-related disease.
date: 2020-09-01
date_type: published
publisher: MDPI
official_url: http://dx.doi.org/10.3390/genes11091043
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1814645
doi: 10.3390/genes11091043
lyricists_name: Bjedov, Ivana
lyricists_name: Rallis, Charalampos
lyricists_id: IBJED78
lyricists_id: RCHAR53
actors_name: Bjedov, Ivana
actors_id: IBJED78
actors_role: owner
full_text_status: public
publication: Genes
volume: 11
number: 9
article_number: 1043
pages: 21
citation:        Bjedov, I;    Rallis, C;      (2020)    The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation.                   Genes , 11  (9)    , Article 1043.  10.3390/genes11091043 <https://doi.org/10.3390/genes11091043>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10117834/1/The%20Target%20of%20Rapamycin%20Signalling%20Pathway%20in%20Ageing%20and%20Lifespan%20Regulation.pdf