eprintid: 10117834 rev_number: 14 eprint_status: archive userid: 608 dir: disk0/10/11/78/34 datestamp: 2020-12-18 09:58:23 lastmod: 2021-09-19 23:19:00 status_changed: 2020-12-18 09:58:23 type: article metadata_visibility: show creators_name: Bjedov, I creators_name: Rallis, C title: The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D09 divisions: B04 divisions: C05 divisions: F42 keywords: ageing, Drosophila, yeast, nutrient-response, autophagy, translation, transcription, metabolism, TORC1, TORC2, MESSENGER-RNA TRANSLATION, AMINO-ACID CONTROL, GENE-EXPRESSION, S6 KINASE, TRANSCRIPTION FACTORS, INSULIN-RESISTANCE, STRESS RESISTANCE, INDUCED OBESITY, POLYMERASE III, CELL-GROWTH note: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited abstract: Ageing is a complex trait controlled by genes and the environment. The highly conserved mechanistic target of rapamycin signalling pathway (mTOR) is a major regulator of lifespan in all eukaryotes and is thought to be mediating some of the effects of dietary restriction. mTOR is a rheostat of energy sensing diverse inputs such as amino acids, oxygen, hormones, and stress and regulates lifespan by tuning cellular functions such as gene expression, ribosome biogenesis, proteostasis, and mitochondrial metabolism. Deregulation of the mTOR signalling pathway is implicated in multiple age-related diseases such as cancer, neurodegeneration, and auto-immunity. In this review, we briefly summarise some of the workings of mTOR in lifespan and ageing through the processes of transcription, translation, autophagy, and metabolism. A good understanding of the pathway’s outputs and connectivity is paramount towards our ability for genetic and pharmacological interventions for healthy ageing and amelioration of age-related disease. date: 2020-09-01 date_type: published publisher: MDPI official_url: http://dx.doi.org/10.3390/genes11091043 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1814645 doi: 10.3390/genes11091043 lyricists_name: Bjedov, Ivana lyricists_name: Rallis, Charalampos lyricists_id: IBJED78 lyricists_id: RCHAR53 actors_name: Bjedov, Ivana actors_id: IBJED78 actors_role: owner full_text_status: public publication: Genes volume: 11 number: 9 article_number: 1043 pages: 21 citation: Bjedov, I; Rallis, C; (2020) The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation. Genes , 11 (9) , Article 1043. 10.3390/genes11091043 <https://doi.org/10.3390/genes11091043>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10117834/1/The%20Target%20of%20Rapamycin%20Signalling%20Pathway%20in%20Ageing%20and%20Lifespan%20Regulation.pdf