TY  - JOUR
AV  - public
IS  - 9
EP  - 21
A1  - Bjedov, I
A1  - Rallis, C
N2  - Ageing is a complex trait controlled by genes and the environment. The highly conserved mechanistic target of rapamycin signalling pathway (mTOR) is a major regulator of lifespan in all eukaryotes and is thought to be mediating some of the effects of dietary restriction. mTOR is a rheostat of energy sensing diverse inputs such as amino acids, oxygen, hormones, and stress and regulates lifespan by tuning cellular functions such as gene expression, ribosome biogenesis, proteostasis, and mitochondrial metabolism. Deregulation of the mTOR signalling pathway is implicated in multiple age-related diseases such as cancer, neurodegeneration, and auto-immunity. In this review, we briefly summarise some of the workings of mTOR in lifespan and ageing through the processes of transcription, translation, autophagy, and metabolism. A good understanding of the pathway?s outputs and connectivity is paramount towards our ability for genetic and pharmacological interventions for healthy ageing and amelioration of age-related disease.
KW  - ageing
KW  -  Drosophila
KW  -  yeast
KW  -  nutrient-response
KW  -  autophagy
KW  -  translation
KW  -  transcription
KW  -  metabolism
KW  -  TORC1
KW  -  TORC2
KW  -  MESSENGER-RNA TRANSLATION
KW  -  AMINO-ACID CONTROL
KW  -  GENE-EXPRESSION
KW  -  S6 KINASE
KW  -  TRANSCRIPTION FACTORS
KW  -  INSULIN-RESISTANCE
KW  -  STRESS RESISTANCE
KW  -  INDUCED OBESITY
KW  -  POLYMERASE III
KW  -  CELL-GROWTH
PB  - MDPI
JF  - Genes
VL  - 11
TI  - The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
ID  - discovery10117834
Y1  - 2020/09/01/
UR  - http://dx.doi.org/10.3390/genes11091043
ER  -