%A M Rashid %A CP Gale %A N Curzen %A P Ludman %A M De Belder %A A Timmis %A MO Mohamed %A TF Lüscher %A J Hains %A J Wu %A A Shoaib %A E Kontopantelis %A C Roebuck %A T Denwood %A J Deanfield %A MA Mamas %J Journal of the American Heart Association %O Copyright © 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attributionâ€NonCommercialâ€NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is nonâ€commercial and no modifications or adaptations are made. %L discovery10116853 %X Background: Studies have reported significant reduction in acute myocardial infarction–related hospitalizations during the coronavirus disease 2019 (COVIDâ€19) pandemic. However, whether these trends are associated with increased incidence of outâ€ofâ€hospital cardiac arrest (OHCA) in this population is unknown. / Methods and Results: Acute myocardial infarction hospitalizations with OHCA during the COVIDâ€19 period (February 1–May 14, 2020) from the Myocardial Ischaemia National Audit Project and British Cardiovascular Intervention Society data sets were analyzed. Temporal trends were assessed using Poisson models with equivalent pre–COVIDâ€19 period (February 1–May 14, 2019) as reference. Acute myocardial infarction hospitalizations during COVIDâ€19 period were reduced by >50% (n=20 310 versus n=9325). OHCA was more prevalent during the COVIDâ€19 period compared with the pre–COVIDâ€19 period (5.6% versus 3.6%), with a 56% increase in the incidence of OHCA (incidence rate ratio, 1.56; 95% CI, 1.39–1.74). Patients experiencing OHCA during COVIDâ€19 period were likely to be older, likely to be women, likely to be of Asian ethnicity, and more likely to present with STâ€segment–elevation myocardial infarction. The overall rates of invasive coronary angiography (58.4% versus 71.6%; P<0.001) were significantly lower among the OHCA group during COVIDâ€19 period with increased time to reperfusion (mean, 2.1 versus 1.1 hours; P=0.05) in those with STâ€segment–elevation myocardial infarction. The adjusted inâ€hospital mortality probability increased from 27.7% in February 2020 to 35.8% in May 2020 in the COVIDâ€19 group (P<.001). / Conclusions: In this national cohort of hospitalized patients with acute myocardial infarction, we observed a significant increase in incidence of OHCA during COVIDâ€19 period paralleled with reduced access to guidelineâ€recommended care and increased inâ€hospital mortality. %C England %D 2020 %K acute myocardial infarction, coronavirus disease 2019, incidence, mortality, outâ€ofâ€hospital cardiac arrest %T Impact of Coronavirus Disease 2019 Pandemic on the Incidence and Management of Outâ€ofâ€Hospital Cardiac Arrest in Patients Presenting With Acute Myocardial Infarction in England %N 22 %V 9