<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10116810> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/dc/terms/title> "Human umbilical cord mesenchymal stromal cells as an adjunct therapy with therapeutic hypothermia in a piglet model of perinatal asphyxia"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/ontology/bibo/abstract> "BACKGROUND: With therapeutic hypothermia (HT) for neonatal encephalopathy, disability rates are reduced, but not all babies benefit. Pre-clinical rodent studies suggest mesenchymal stromal cells (MSCs) augment HT protection. AIMS: The authors studied the efficacy of intravenous (IV) or intranasal (IN) human umbilical cord-derived MSCs (huMSCs) as adjunct therapy to HT in a piglet model. METHODS: A total of 17 newborn piglets underwent transient cerebral hypoxia-ischemia (HI) and were then randomized to (i) HT at 33.5°C 1-13 h after HI (n = 7), (ii) HT+IV huMSCs (30 × 106 cells) at 24 h and 48 h after HI (n = 5) or (iii) HT+IN huMSCs (30 × 106 cells) at 24 h and 48 h after HI (n = 5). Phosphorus-31 and hydrogen-1 magnetic resonance spectroscopy (MRS) was performed at 30 h and 72 h and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells and oligodendrocytes quantified. In two further piglets, 30 × 106 IN PKH-labeled huMSCs were administered. RESULTS: HI severity was similar between groups. Amplitude-integrated electroencephalogram (aEEG) recovery was more rapid for HT+IN huMSCs compared with HT from 25 h to 42 h and 49 h to 54 h (P ≤ 0.05). MRS phosphocreatine/inorganic phosphate was higher on day 2 in HT+IN huMSCs than HT (P = 0.035). Comparing HT+IN huMSCs with HT and HT+IV huMSCs, there were increased OLIG2 counts in hippocampus (P = 0.011 and 0.018, respectively), internal capsule (P = 0.013 and 0.037, respectively) and periventricular white matter (P = 0.15 for IN versus IV huMSCs). Reduced TUNEL-positive cells were seen in internal capsule with HT+IN huMSCs versus HT (P = 0.05). PKH-labeled huMSCs were detected in the brain 12 h after IN administration. CONCLUSIONS: After global HI, compared with HT alone, the authors saw beneficial effects of HT+IN huMSCs administered at 24 h and 48 h (30 × 106 cells/kg total dose) based on more rapid aEEG recovery, improved 31P MRS brain energy metabolism and increased oligodendrocyte survival at 72 h."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/dc/terms/date> "2020-11-28" .
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<https://discovery.ucl.ac.uk/id/publication/ext-4aa6726a88bfc5258a055fff4e13d1b3> <http://xmlns.com/foaf/0.1/name> "Cytotherapy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-4aa6726a88bfc5258a055fff4e13d1b3> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/forthcoming> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1cc93218e495fa2ad49959ff1c051872> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116810#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-820239bd58d73c91106faa772f1de737> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116810#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d82a1e40e64a3695781040144646f638> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116810#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10116810#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-d82a1e40e64a3695781040144646f638> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7151e945677206fb96325322ac8a3f12> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116810#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10116810#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-7151e945677206fb96325322ac8a3f12> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-eef4fc1e6fd273694fca463567fb4560> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116810#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10116810#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-eef4fc1e6fd273694fca463567fb4560> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ad04338c9d296c80452187b3ee136afb> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116810#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10116810#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-ad04338c9d296c80452187b3ee136afb> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4d191ca6cf8c0e1537faf43cd6d35a8d> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116810#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10116810#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-4d191ca6cf8c0e1537faf43cd6d35a8d> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5092a3e496e201c45f96e1eff562f19c> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116810#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10116810#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-5092a3e496e201c45f96e1eff562f19c> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f9a34a87a3ee4bc90679396654949813> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116810#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10116810#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-f9a34a87a3ee4bc90679396654949813> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fd222067911338830d82a2a6499b98bb> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116810#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10116810#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-fd222067911338830d82a2a6499b98bb> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-cac9e4fb1468b47ea9d69f6497cf29e3> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116810#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10116810#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-cac9e4fb1468b47ea9d69f6497cf29e3> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b772f7b01c188d2b97701daf66e6b550> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116810#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10116810#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-b772f7b01c188d2b97701daf66e6b550> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-55d56018f02b90c35eada6c41158edef> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116810#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10116810#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-55d56018f02b90c35eada6c41158edef> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-68b571391c57744f4dc2582cab179cf3> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116810#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10116810#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-68b571391c57744f4dc2582cab179cf3> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2b52aab9d717eb449ff8862fde1335ee> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116810#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10116810#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-2b52aab9d717eb449ff8862fde1335ee> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-699c7580eed63e401d97d340758fc2ce> .
<https://discovery.ucl.ac.uk/id/eprint/10116810> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116810#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10116810#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-699c7580eed63e401d97d340758fc2ce> .
<https://discovery.ucl.ac.uk/id/person/ext-2b52aab9d717eb449ff8862fde1335ee> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2b52aab9d717eb449ff8862fde1335ee> <http://xmlns.com/foaf/0.1/givenName> "B"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2b52aab9d717eb449ff8862fde1335ee> <http://xmlns.com/foaf/0.1/familyName> "Weil"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2b52aab9d717eb449ff8862fde1335ee> <http://xmlns.com/foaf/0.1/name> "B Weil"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f9a34a87a3ee4bc90679396654949813> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-f9a34a87a3ee4bc90679396654949813> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f9a34a87a3ee4bc90679396654949813> <http://xmlns.com/foaf/0.1/familyName> "Sokolska"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f9a34a87a3ee4bc90679396654949813> <http://xmlns.com/foaf/0.1/name> "M Sokolska"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d82a1e40e64a3695781040144646f638> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d82a1e40e64a3695781040144646f638> <http://xmlns.com/foaf/0.1/givenName> "KA"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d82a1e40e64a3695781040144646f638> <http://xmlns.com/foaf/0.1/familyName> "Martinello"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d82a1e40e64a3695781040144646f638> <http://xmlns.com/foaf/0.1/name> "KA Martinello"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fd222067911338830d82a2a6499b98bb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-fd222067911338830d82a2a6499b98bb> <http://xmlns.com/foaf/0.1/givenName> "X"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fd222067911338830d82a2a6499b98bb> <http://xmlns.com/foaf/0.1/familyName> "Charalambous"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fd222067911338830d82a2a6499b98bb> <http://xmlns.com/foaf/0.1/name> "X Charalambous"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4d191ca6cf8c0e1537faf43cd6d35a8d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4d191ca6cf8c0e1537faf43cd6d35a8d> <http://xmlns.com/foaf/0.1/givenName> "I"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4d191ca6cf8c0e1537faf43cd6d35a8d> <http://xmlns.com/foaf/0.1/familyName> "Lingam"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4d191ca6cf8c0e1537faf43cd6d35a8d> <http://xmlns.com/foaf/0.1/name> "I Lingam"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-820239bd58d73c91106faa772f1de737> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-820239bd58d73c91106faa772f1de737> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-820239bd58d73c91106faa772f1de737> <http://xmlns.com/foaf/0.1/familyName> "Meehan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-820239bd58d73c91106faa772f1de737> <http://xmlns.com/foaf/0.1/name> "C Meehan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b772f7b01c188d2b97701daf66e6b550> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b772f7b01c188d2b97701daf66e6b550> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b772f7b01c188d2b97701daf66e6b550> <http://xmlns.com/foaf/0.1/familyName> "Hristova"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b772f7b01c188d2b97701daf66e6b550> <http://xmlns.com/foaf/0.1/name> "M Hristova"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-55d56018f02b90c35eada6c41158edef> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-55d56018f02b90c35eada6c41158edef> <http://xmlns.com/foaf/0.1/givenName> "BW"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-55d56018f02b90c35eada6c41158edef> <http://xmlns.com/foaf/0.1/familyName> "Kramer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-55d56018f02b90c35eada6c41158edef> <http://xmlns.com/foaf/0.1/name> "BW Kramer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-699c7580eed63e401d97d340758fc2ce> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-699c7580eed63e401d97d340758fc2ce> <http://xmlns.com/foaf/0.1/givenName> "MW"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-699c7580eed63e401d97d340758fc2ce> <http://xmlns.com/foaf/0.1/familyName> "Lowdell"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-699c7580eed63e401d97d340758fc2ce> <http://xmlns.com/foaf/0.1/name> "MW Lowdell"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-68b571391c57744f4dc2582cab179cf3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-68b571391c57744f4dc2582cab179cf3> <http://xmlns.com/foaf/0.1/givenName> "X"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-68b571391c57744f4dc2582cab179cf3> <http://xmlns.com/foaf/0.1/familyName> "Golay"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-68b571391c57744f4dc2582cab179cf3> <http://xmlns.com/foaf/0.1/name> "X Golay"^^<http://www.w3.org/2001/XMLSchema#string> .
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