eprintid: 10116371 rev_number: 26 eprint_status: archive userid: 608 dir: disk0/10/11/63/71 datestamp: 2020-12-07 18:09:21 lastmod: 2022-01-13 23:32:10 status_changed: 2020-12-07 18:09:21 type: proceedings_section metadata_visibility: show creators_name: Murdoch, R creators_name: Kawadler, J creators_name: Kirkham, F creators_name: Shmueli, K title: Investigating the effect of prior stroke on regional brain iron concentrations in children with sickle cell anaemia using MRI susceptibility mapping ispublished: pub divisions: UCL divisions: B02 divisions: D13 divisions: G26 divisions: B04 divisions: C05 divisions: F42 note: This version is the version of record. For information on re-use, please refer to the publisher's terms and conditions. abstract: Regional iron concentrations in the brains of children with Sickle Cell Anaemia Regional iron concentrations in the brains of children with Sickle Cell Anaemia (SCA) were examined using susceptibility mapping (SM), in the (SCA) were examined using susceptibility mapping (SM), in the fifirst study to apply rst study to apply SM to an African cohort in Tanzania. Mean susceptibility values in three deep- SM to an African cohort in Tanzania. Mean susceptibility values in three deepbrain regions were compared to age, blood ferritin levels and history of clinical brain regions were compared to age, blood ferritin levels and history of clinical stroke. Mean susceptibility values increased linearly with age, but there was no stroke. Mean susceptibility values increased linearly with age, but there was no signi signifificant correlation between susceptibility values and blood ferritin levels. cant correlation between susceptibility values and blood ferritin levels. SCA patients who had su SCA patients who had suffffered stroke prior to MRI had signi ered stroke prior to MRI had signifificantly lower cantly lower susceptibility values than stroke-free patients. This may suggest a role for iron susceptibility values than stroke-free patients. This may suggest a role for iron dedefificiency in stroke in SCA. ciency in stroke in SCA. date: 2018 date_type: published official_url: https://www.ismrm.org/18m/ oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1832820 lyricists_name: Kirkham, Fenella lyricists_name: Murdoch, Russell lyricists_name: Shmueli, Karin lyricists_id: FKIRK91 lyricists_id: RMURD33 lyricists_id: KSHMU54 actors_name: Murdoch, Russell actors_id: RMURD33 actors_role: owner full_text_status: public place_of_pub: International Society for Magnetic Resonance in Medicine (ISMRM) pagerange: 1-3 event_title: Joint Annual Meeting ISMRM-ESMRMB 2018. SMRT 27th Annual Meeting event_location: Paris, France event_dates: 16th-21st June 2018 institution: 26th Annual Meeting of the ISMRM book_title: Proceedings of the Joint Annual Meeting ISMRM-ESMRMB 2018. SMRT 27th Annual Meeting citation: Murdoch, R; Kawadler, J; Kirkham, F; Shmueli, K; (2018) Investigating the effect of prior stroke on regional brain iron concentrations in children with sickle cell anaemia using MRI susceptibility mapping. In: Proceedings of the Joint Annual Meeting ISMRM-ESMRMB 2018. SMRT 27th Annual Meeting. (pp. pp. 1-3). : International Society for Magnetic Resonance in Medicine (ISMRM). Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10116371/1/Murdoch_ISMRM_2018_Prior_Stroke_SCA.pdf