Cree, BAC; Cutter, G; Wolinsky, JS; Freedman, MS; Comi, G; Giovannoni, G; Hartung, HP; ... Perminder, B; + view all Cree, BAC; Cutter, G; Wolinsky, JS; Freedman, MS; Comi, G; Giovannoni, G; Hartung, HP; Arnold, D; Kuhle, J; Block, V; Munschauer, FE; Sedel, F; Lublin, FD; Reingold, S; Duquette, P; Derfuss, T; Fazekas, F; Sormani, MP; Lisak, RP; Graves, J; Krieger, S; Zabad, RK; Newsome, S; Barton, J; MacDonell, R; Marriott, M; De Klippel, N; Laureys, G; Willekens, B; Devonshire, V; Freedman, M; Girard, JM; Giacomini, P; McKelvey, R; Selchen, D; Vorobeychik, G; Witkowski, L; Ampapa, R; Preiningerova, JL; Meluzinova, E; Talab, R; Vachova, M; Aktas, O; Buttmann, M; Birte, EH; Kuempfel, T; Friedemann, P; Rau, D; Reifschneider, G; Sokolowski, P; Tumani, H; Satori, M; Pozzilli, C; Klosek, A; Koscielniak, J; Waldemar, F; Zajda, M; Gonzalez, RA; Ayuso, GI; Sanchez, VF; Guevara, CO; Rodriguez, JEM; Montalban, X; Ramio-Torrenta, L; Brundin, L; Lycke, J; Terzi, M; Guadagno, J; Mahad, D; Pace, A; Schmierer, K; Toosy, A; Webb, S; Agius, M; Amezcua, L; Apperson, M; Bagert, B; Bandari, D; Bernitsas, E; Calkwood, J; Carter, J; Cohen, B; Conway, D; Cooper, J; Corboy, J; Coyle, P; Cree, B; Freedman, M; Ford, C; Fox, E; Goldman, M; Greenberg, B; Kita, M; Leist, T; Lynch, S; Miller, A; Moses, H; Naismith, R; Picone, MA; Perminder, B; - view fewer (2020) Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet Neurology , 19 (12) pp. 988-997. 10.1016/S1474-4422(20)30347-1.