<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10116002> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/dc/terms/title> "The effect of intracoronary infusion of bone marrow-derived mononuclear cells on all-cause mortality in acute myocardial infarction: the BAMI trial"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/ontology/bibo/abstract> "Aims: \r\nBone marrow-derived mononuclear cell (BM-MNC) therapy may improve myocardial recovery in patients following acute myocardial infarction (AMI), though existing trial results are inconsistent.\r\n\r\nMethods and results: \r\nOriginally an open-label, multicentre Phase III trial, BAMI was designed to demonstrate the safety and efficacy of intracoronary infusion of BM-MNCs in reducing the time to all-cause mortality in patients with reduced left ventricular ejection fraction (LVEF, ≤45%) after primary angioplasty (PPCI) for ST-elevation AMI. Unexpectedly low recruitment means the trial no longer qualifies as a hypothesis-testing trial, but is instead an observational study with no definitive conclusions possible from statistical analysis. In total, 375 patients were recruited: 185 patients were randomized to the treatment arm (intracoronary infusion of BM-MNCs 2–8 days after PPCI) and 190 patients to the control arm (optimal medical therapy). All-cause mortality at 2 years was 3.26% [6 deaths; 95% confidence interval (CI): 1.48–7.12%] in the BM-MNC group and 3.82% (7 deaths; 95% CI: 1.84–7.84%) in the control group. Five patients (2.7%, 95% CI: 1.0–5.9%) in the BM-MNC group and 15 patients (8.1%, CI : 4.7–12.5%) in the control group were hospitalized for heart failure during 2 years of follow-up. Neither adverse events nor serious adverse events differed between the two groups. There were no patients hospitalized for stroke in the control group and 4 (2.2%) patients hospitalized for stroke in the BM-MNC group.\r\n\r\nConclusions:\r\nAlthough BAMI is the largest trial of autologous cell-based therapy in the treatment of AMI, unexpectedly low recruitment and event rates preclude any meaningful group comparisons and interpretation of the observed results."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/dc/terms/date> "2020-10-07" . <https://discovery.ucl.ac.uk/id/document/1222034> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/ontology/bibo/volume> "41" . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/ontology/bibo/issue> "38" . <https://discovery.ucl.ac.uk/id/org/ext-daeb92daf570917684167066877da0ed> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> 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<http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-eb0c32c6dade6913cb794978daf6ff59> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-beaab76ebe154c77c58d5260ee5339e5> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> . <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-beaab76ebe154c77c58d5260ee5339e5> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5f66dffd3638ac9faefc76a828c9cf32> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> . <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-5f66dffd3638ac9faefc76a828c9cf32> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-387b675f257a4899e528e65ce89f29e0> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> . <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-387b675f257a4899e528e65ce89f29e0> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0b169028460df91dab8668686e271072> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> . <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-0b169028460df91dab8668686e271072> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f08250f7093c4eaca8a5e3dd8e6b9bb9> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> . <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-f08250f7093c4eaca8a5e3dd8e6b9bb9> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-313366f4608aa6d55d26ba0cb184a3d0> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> . <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-313366f4608aa6d55d26ba0cb184a3d0> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-63408bd2d9c3ca7a10bc24602e5e7b4e> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> . <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-63408bd2d9c3ca7a10bc24602e5e7b4e> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-21b9c042ecf784d17f15ca69d9845337> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> . <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-21b9c042ecf784d17f15ca69d9845337> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b33098d9dcc0c9b4915c5edd941ed03c> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> . <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-b33098d9dcc0c9b4915c5edd941ed03c> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4351df6f9e30600bb85c5be7965c4c92> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> . <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-4351df6f9e30600bb85c5be7965c4c92> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c77e1bf703bd30d2267e045b20ae2fde> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> . <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_17> <https://discovery.ucl.ac.uk/id/person/ext-c77e1bf703bd30d2267e045b20ae2fde> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6fba6eeba578488c0cf833da6e3fae06> . <https://discovery.ucl.ac.uk/id/eprint/10116002> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> . <https://discovery.ucl.ac.uk/id/eprint/10116002#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_18> <https://discovery.ucl.ac.uk/id/person/ext-6fba6eeba578488c0cf833da6e3fae06> . <https://discovery.ucl.ac.uk/id/person/ext-c77e1bf703bd30d2267e045b20ae2fde> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-c77e1bf703bd30d2267e045b20ae2fde> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c77e1bf703bd30d2267e045b20ae2fde> <http://xmlns.com/foaf/0.1/familyName> "Ylä-Herttuala"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c77e1bf703bd30d2267e045b20ae2fde> <http://xmlns.com/foaf/0.1/name> "S Ylä-Herttuala"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0b169028460df91dab8668686e271072> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-0b169028460df91dab8668686e271072> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0b169028460df91dab8668686e271072> <http://xmlns.com/foaf/0.1/familyName> "Hauskeller"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0b169028460df91dab8668686e271072> <http://xmlns.com/foaf/0.1/name> "C Hauskeller"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b33098d9dcc0c9b4915c5edd941ed03c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-b33098d9dcc0c9b4915c5edd941ed03c> <http://xmlns.com/foaf/0.1/givenName> "P"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b33098d9dcc0c9b4915c5edd941ed03c> <http://xmlns.com/foaf/0.1/familyName> "Menasché"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b33098d9dcc0c9b4915c5edd941ed03c> <http://xmlns.com/foaf/0.1/name> "P Menasché"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9eff0a24e3d19891e847765cc48e7cf5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-9eff0a24e3d19891e847765cc48e7cf5> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9eff0a24e3d19891e847765cc48e7cf5> <http://xmlns.com/foaf/0.1/familyName> "Bartunek"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9eff0a24e3d19891e847765cc48e7cf5> <http://xmlns.com/foaf/0.1/name> "J Bartunek"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5f66dffd3638ac9faefc76a828c9cf32> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-5f66dffd3638ac9faefc76a828c9cf32> <http://xmlns.com/foaf/0.1/givenName> "M-C"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5f66dffd3638ac9faefc76a828c9cf32> <http://xmlns.com/foaf/0.1/familyName> "Good"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5f66dffd3638ac9faefc76a828c9cf32> <http://xmlns.com/foaf/0.1/name> "M-C Good"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f0d8704ecf1919ac05009829b1ea16a7> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-f0d8704ecf1919ac05009829b1ea16a7> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f0d8704ecf1919ac05009829b1ea16a7> <http://xmlns.com/foaf/0.1/familyName> "Mathur"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f0d8704ecf1919ac05009829b1ea16a7> <http://xmlns.com/foaf/0.1/name> "A Mathur"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-387b675f257a4899e528e65ce89f29e0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-387b675f257a4899e528e65ce89f29e0> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-387b675f257a4899e528e65ce89f29e0> <http://xmlns.com/foaf/0.1/familyName> "Hartikainen"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-387b675f257a4899e528e65ce89f29e0> <http://xmlns.com/foaf/0.1/name> "J Hartikainen"^^<http://www.w3.org/2001/XMLSchema#string> . 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