eprintid: 10115746
rev_number: 14
eprint_status: archive
userid: 608
dir: disk0/10/11/57/46
datestamp: 2020-11-24 11:08:04
lastmod: 2021-09-28 22:09:28
status_changed: 2020-11-24 11:08:04
type: article
metadata_visibility: show
creators_name: Wolters, EE
creators_name: Van de Beek, M
creators_name: Ossenkoppele, R
creators_name: Golla, SSV
creators_name: Verfaillie, SCJ
creators_name: Coomans, EM
creators_name: Timmers, T
creators_name: Visser, D
creators_name: Tuncel, H
creators_name: Barkhof, F
creators_name: Boellaard, R
creators_name: Windhorst, AD
creators_name: Van der Flier, WM
creators_name: Scheltens, PH
creators_name: Lemstra, AW
creators_name: Van Berckel, BNM
title: Tau PET and relative cerebral blood flow in Dementia with Lewy bodies: A PET study
ispublished: inpress
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F82
keywords: tau, relative cerebral blood flow, FDG PET, Dementia with Lewy bodies, cognition
note: This is an Open Access article published under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) Licence (https://creativecommons.org/licenses/by-nc-nd/4.0/).
abstract: Purpose: Alpha-synuclein often co-occurs with Alzheimer’s disease (AD) pathology in Dementia with Lewy Bodies (DLB). From a dynamic [18F]flortaucipir PET scan we derived measures of both tau binding and relative cerebral blood flow (rCBF). We tested whether regional tau binding or rCBF differed between DLB patients and AD patients and controls and examined their association with clinical characteristics of DLB. /

Methods: Eighteen patients with probable DLB, 65 AD patients and 50 controls underwent a dynamic 130-minute [18F]flortaucipir PET scan. DLB patients with positive biomarkers for AD based on cerebrospinal fluid or amyloid PET were considered as DLB with AD pathology(DLB-AD+). Receptor parametric mapping(cerebellar gray matter reference region) was used to extract regional binding potential (BPND) and R1, reflecting (AD-specific) tau pathology and rCBF, respectively. First, we performed regional comparisons of [18F]flortaucipir BPND and R1 between diagnostic groups. In DLB patients only, we performed regression analyses between regional [18F]flortaucipir BPND, R1 and performance on ten neuropsychological tests. /

Results: Regional [18F]flortaucipir BPND in DLB was comparable with tau binding in controls (p>0.05). Subtle higher tau binding was observed in DLB-AD+ compared to DLB-AD- in the medial temporal and parietal lobe (both p<0.05). Occipital and lateral parietal R1 was lower in DLB compared to AD and controls (all p<0.01). Lower frontal R1 was associated with impaired performance on digit span forward (standardized beta, stβ=0.72) and category fluency (stβ=0.69) tests. Lower parietal R1 was related to lower delayed (stβ=0.50) and immediate (stβ=0.48) recall, VOSP number location (stβ=0.70) and fragmented letters (stβ=0.59) scores. Lower occipital R1 was associated to worse performance on VOSP fragmented letters (stβ=0.61), all p<0.05. /

Conclusion: The amount of tau binding in DLB was minimal and did not differ from controls. However, there were DLB-specific occipital and lateral parietal relative cerebral blood flow reductions compared to both controls and AD patients. Regional rCBF, but not tau binding, was related to cognitive impairment. This indicates that assessment of rCBF may give more insight into disease mechanisms in DLB than tau PET.
date: 2020-11-19
date_type: published
publisher: Elsevier BV
official_url: https://doi.org/10.1016/j.nicl.2020.102504
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1829688
doi: 10.1016/j.nicl.2020.102504
lyricists_name: Barkhof, Frederik
lyricists_id: FBARK32
actors_name: Austen, Jennifer
actors_id: JAUST66
actors_role: owner
full_text_status: public
publication: NeuroImage: Clinical
article_number: 102504
citation:        Wolters, EE;    Van de Beek, M;    Ossenkoppele, R;    Golla, SSV;    Verfaillie, SCJ;    Coomans, EM;    Timmers, T;                                     ... Van Berckel, BNM; + view all <#>        Wolters, EE;  Van de Beek, M;  Ossenkoppele, R;  Golla, SSV;  Verfaillie, SCJ;  Coomans, EM;  Timmers, T;  Visser, D;  Tuncel, H;  Barkhof, F;  Boellaard, R;  Windhorst, AD;  Van der Flier, WM;  Scheltens, PH;  Lemstra, AW;  Van Berckel, BNM;   - view fewer <#>    (2020)    Tau PET and relative cerebral blood flow in Dementia with Lewy bodies: A PET study.                   NeuroImage: Clinical      , Article 102504.  10.1016/j.nicl.2020.102504 <https://doi.org/10.1016/j.nicl.2020.102504>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10115746/1/1-s2.0-S2213158220303417-main.pdf