<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10114821> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/dc/terms/title> "Routine serum biomarkers, but not dual-energy X-ray absorptiometry, correlate with cortical bone mineral density in children and young adults with chronic kidney disease"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/abstract> "BACKGROUND: Biomarkers and dual-energy X-ray absorptiometry (DXA) are thought to be poor predictors of bone mineral density (BMD). The Kidney Disease: Improving Global Outcomes guidelines suggest using DXA if the results will affect patient management, but this has not been studied in children or young adults in whom bone mineral accretion continues to 30 years of age. We studied the clinical utility of DXA and serum biomarkers against tibial cortical BMD (CortBMD) measured by peripheral quantitative computed tomography, expressed as Z-score CortBMD, which predicts fracture risk. METHODS: This was a cross-sectional multicentre study in 26 patients with CKD4 and 5 and 77 on dialysis. RESULTS: Significant bone pain that hindered activities of daily living was present in 58%, and 10% had at least one low-trauma fracture. CortBMD and cortical mineral content Z-scores were lower in dialysis compared with CKD patients (P = 0.004 and P = 0.02). DXA BMD hip and lumbar spine Z-scores did not correlate with CortBMD or biomarkers. CortBMD was negatively associated with parathyroid hormone (PTH; r = -0.44, P < 0.0001) and alkaline phosphatase (ALP; r = -0.22, P = 0.03) and positively with calcium (Ca; r = 0.33, P = 0.001). At PTH <3 times upper limit of normal, none of the patients had a CortBMD below -2 SD (odds ratio 95% confidence interval 7.331 to infinity). On multivariable linear regression PTH (β = -0.43 , P < 0.0001), ALP (β = -0.36, P < 0.0001) and Ca (β = 0.21, P = 0.005) together predicted 57% of variability in CortBMD. DXA measures did not improve this model. CONCLUSIONS: Taken together, routinely used biomarkers, PTH, ALP and Ca, but not DXA, are moderate predictors of cortical BMD. DXA is not clinically useful and should not be routinely performed in children and young adults with CKD 4-5D."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/dc/terms/date> "2021-10" . <https://discovery.ucl.ac.uk/id/document/1214301> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/volume> "36" . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/issue> "10" . <https://discovery.ucl.ac.uk/id/publication/ext-0e0014604668873646c844608bf91b33> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-0e0014604668873646c844608bf91b33> <http://xmlns.com/foaf/0.1/name> "Nephrology Dialysis Transplantation"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-0e0014604668873646c844608bf91b33> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0fe67c39bd0e97c1cd037c90a494dc91> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> . <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-0fe67c39bd0e97c1cd037c90a494dc91> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-deb5e0d562797e9c576bd5b48edc41e4> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> . <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-deb5e0d562797e9c576bd5b48edc41e4> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a73be8b7d5a2044ea13ee1344d0078c3> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> . <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-a73be8b7d5a2044ea13ee1344d0078c3> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-eee755bd45b6e915ee78e4f12e356ad2> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> . <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-eee755bd45b6e915ee78e4f12e356ad2> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7f152c70f40b113dc16273b04b2263f8> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> . <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-7f152c70f40b113dc16273b04b2263f8> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-240b169511017710dc6ae6ab1ae244b4> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> . <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-240b169511017710dc6ae6ab1ae244b4> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e8b78b6d9af7aaf42dfc7b0014b4107b> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> . <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-e8b78b6d9af7aaf42dfc7b0014b4107b> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ecec09ba3e215fe2239ad437ac0f8999> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> . <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-ecec09ba3e215fe2239ad437ac0f8999> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-32f81d6850b7ab84df632eb6243954f8> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> . <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-32f81d6850b7ab84df632eb6243954f8> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-87b31a48609b8017db166c89a78de94b> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> . <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-87b31a48609b8017db166c89a78de94b> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-352d27263cf52d84eee58531fa659f6d> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> . <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-352d27263cf52d84eee58531fa659f6d> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-53449abe61678d6b1c6995bb477c63c0> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> . <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-53449abe61678d6b1c6995bb477c63c0> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8f66c299fce234394000fa4b71be904f> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> . <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-8f66c299fce234394000fa4b71be904f> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-14bfd7abe29f77800054e590ae3e89c1> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> . <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-14bfd7abe29f77800054e590ae3e89c1> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-768308e9bdf92ec5cdf7d1d35983b39b> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> . <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-768308e9bdf92ec5cdf7d1d35983b39b> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1205a89ce6047b45bc875750c1cb25d0> . <https://discovery.ucl.ac.uk/id/eprint/10114821> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> . <https://discovery.ucl.ac.uk/id/eprint/10114821#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-1205a89ce6047b45bc875750c1cb25d0> . <https://discovery.ucl.ac.uk/id/person/ext-14bfd7abe29f77800054e590ae3e89c1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-14bfd7abe29f77800054e590ae3e89c1> <http://xmlns.com/foaf/0.1/givenName> "MB"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-14bfd7abe29f77800054e590ae3e89c1> <http://xmlns.com/foaf/0.1/familyName> "Leonard"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-14bfd7abe29f77800054e590ae3e89c1> <http://xmlns.com/foaf/0.1/name> "MB Leonard"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a73be8b7d5a2044ea13ee1344d0078c3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-a73be8b7d5a2044ea13ee1344d0078c3> <http://xmlns.com/foaf/0.1/givenName> "CJ"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a73be8b7d5a2044ea13ee1344d0078c3> <http://xmlns.com/foaf/0.1/familyName> "Ferro"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a73be8b7d5a2044ea13ee1344d0078c3> <http://xmlns.com/foaf/0.1/name> "CJ Ferro"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-352d27263cf52d84eee58531fa659f6d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-352d27263cf52d84eee58531fa659f6d> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-352d27263cf52d84eee58531fa659f6d> <http://xmlns.com/foaf/0.1/familyName> "Popoola"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-352d27263cf52d84eee58531fa659f6d> <http://xmlns.com/foaf/0.1/name> "J Popoola"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-eee755bd45b6e915ee78e4f12e356ad2> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-eee755bd45b6e915ee78e4f12e356ad2> <http://xmlns.com/foaf/0.1/givenName> "V"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-eee755bd45b6e915ee78e4f12e356ad2> <http://xmlns.com/foaf/0.1/familyName> "Askiti"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-eee755bd45b6e915ee78e4f12e356ad2> <http://xmlns.com/foaf/0.1/name> "V Askiti"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e8b78b6d9af7aaf42dfc7b0014b4107b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-e8b78b6d9af7aaf42dfc7b0014b4107b> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e8b78b6d9af7aaf42dfc7b0014b4107b> <http://xmlns.com/foaf/0.1/familyName> "Kaur"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e8b78b6d9af7aaf42dfc7b0014b4107b> <http://xmlns.com/foaf/0.1/name> "A Kaur"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-240b169511017710dc6ae6ab1ae244b4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-240b169511017710dc6ae6ab1ae244b4> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-240b169511017710dc6ae6ab1ae244b4> <http://xmlns.com/foaf/0.1/familyName> "Biassoni"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-240b169511017710dc6ae6ab1ae244b4> <http://xmlns.com/foaf/0.1/name> "L Biassoni"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7f152c70f40b113dc16273b04b2263f8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-7f152c70f40b113dc16273b04b2263f8> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7f152c70f40b113dc16273b04b2263f8> <http://xmlns.com/foaf/0.1/familyName> "Mitsioni"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7f152c70f40b113dc16273b04b2263f8> <http://xmlns.com/foaf/0.1/name> "A Mitsioni"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-53449abe61678d6b1c6995bb477c63c0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-53449abe61678d6b1c6995bb477c63c0> <http://xmlns.com/foaf/0.1/givenName> "DV"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-53449abe61678d6b1c6995bb477c63c0> <http://xmlns.com/foaf/0.1/familyName> "Milford"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-53449abe61678d6b1c6995bb477c63c0> <http://xmlns.com/foaf/0.1/name> "DV Milford"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1205a89ce6047b45bc875750c1cb25d0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-1205a89ce6047b45bc875750c1cb25d0> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1205a89ce6047b45bc875750c1cb25d0> <http://xmlns.com/foaf/0.1/familyName> "Shroff"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1205a89ce6047b45bc875750c1cb25d0> <http://xmlns.com/foaf/0.1/name> "R Shroff"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-deb5e0d562797e9c576bd5b48edc41e4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-deb5e0d562797e9c576bd5b48edc41e4> <http://xmlns.com/foaf/0.1/givenName> "NJ"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-deb5e0d562797e9c576bd5b48edc41e4> <http://xmlns.com/foaf/0.1/familyName> "Crabtree"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-deb5e0d562797e9c576bd5b48edc41e4> 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