eprintid: 10114816
rev_number: 21
eprint_status: archive
userid: 608
dir: disk0/10/11/48/16
datestamp: 2020-11-13 11:57:59
lastmod: 2021-09-28 22:27:09
status_changed: 2020-11-13 11:57:59
type: article
metadata_visibility: show
creators_name: Zhuo, Z
creators_name: Duan, Y
creators_name: Tian, D
creators_name: Wang, X
creators_name: Gao, C
creators_name: Ding, J
creators_name: Zheng, F
creators_name: Zhang, T
creators_name: Zhang, X
creators_name: Barkhof, F
creators_name: Shi, F-D
creators_name: Liu, Y
title: Brain structural and functional alterations in MOG antibody disease.
ispublished: inpress
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F82
keywords: Myelin oligodendrocyte glycoprotein associated disease, degree centrality, fractional anisotropy, gray matter volume, mean diffusivity, multimodal MRI
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: BACKGROUND: The impact of myelin oligodendrocyte glycoprotein antibody disease (MOGAD) on brain structure and function is unknown. OBJECTIVES: The aim of this study was to study the multimodal brain MRI alterations in MOGAD and to investigate their clinical significance. METHODS: A total of 17 MOGAD, 20 aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders (AQP4 + NMOSD), and 28 healthy controls (HC) were prospectively recruited. Voxel-wise gray matter (GM) volume, fractional anisotropy (FA), mean diffusivity (MD), and degree centrality (DC) were compared between groups. Clinical associations and differential diagnosis were determined using partial correlation and stepwise logistic regression. RESULTS: In comparison with HC, MOGAD had GM atrophy in frontal and temporal lobe, insula, thalamus, and hippocampus, and WM fiber disruption in optic radiation and anterior/posterior corona radiata; DC decreased in cerebellum and increased in temporal lobe. Compared to AQP4 + NMOSD, MOGAD presented lower GM volume in postcentral gyrus and decreased DC in cerebellum. Hippocampus/parahippocampus atrophy associated with Expanded Disability Status Scale (R = -0.55, p = 0.04) and California Verbal Learning Test (R = 0.62, p = 0.031). The differentiation of MOGAD from AQP4 + NMOSD achieved an accuracy of 95% using FA in splenium of corpus callosum and DC in occipital gyrus. CONCLUSION: Distinct structural and functional alterations were identified in MOGAD. Hippocampus/parahippocampus atrophy associated with clinical disability and cognitive impairment.
date: 2020-10-15
date_type: published
official_url: https://doi.org/10.1177/1352458520964415
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1823640
doi: 10.1177/1352458520964415
language_elements: eng
lyricists_name: Barkhof, Frederik
lyricists_id: FBARK32
actors_name: Barczynska, Patrycja
actors_id: PBARC91
actors_role: owner
full_text_status: public
publication: Multiple Sclerosis Journal
event_location: England
citation:        Zhuo, Z;    Duan, Y;    Tian, D;    Wang, X;    Gao, C;    Ding, J;    Zheng, F;                     ... Liu, Y; + view all <#>        Zhuo, Z;  Duan, Y;  Tian, D;  Wang, X;  Gao, C;  Ding, J;  Zheng, F;  Zhang, T;  Zhang, X;  Barkhof, F;  Shi, F-D;  Liu, Y;   - view fewer <#>    (2020)    Brain structural and functional alterations in MOG antibody disease.                   Multiple Sclerosis Journal        10.1177/1352458520964415 <https://doi.org/10.1177/1352458520964415>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10114816/1/Zhou_Brain_structural_MSJ_accepterd_version.pdf