<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10114475> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/dc/terms/title> "Brain-derived neurotrophic factor in cerebrospinal fluid and plasma is not a biomarker for Huntington's disease"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/ontology/bibo/abstract> "Brain-derived neurotrophic factor (BDNF) is implicated in the survival of striatal neurons. BDNF function is reduced in Huntington’s disease (HD), possibly because mutant huntingtin impairs its cortico-striatal transport, contributing to striatal neurodegeneration. The BDNF trophic pathway is a therapeutic target, and blood BDNF has been suggested as a potential biomarker for HD, but BDNF has not been quantified in cerebrospinal fluid (CSF) in HD.\r\n\r\nBDNF in CSF and plasma in the HD-CSF cohort (20 pre-manifest and 40 manifest HD mutation carriers and 20 age and gender-matched controls) were quantified using conventional ELISAs and an ultra-sensitive immunoassay.\r\n\r\nBDNF concentration was below the limit of detection of the conventional ELISAs, raising doubt about previous CSF reports in neurodegeneration. Using the ultra-sensitive method, BDNF concentration was quantifiable in all samples but did not differ between controls and HD mutation carriers in CSF or plasma, was not associated with clinical scores or MRI brain volumetric measures, and had poor ability to discriminate controls from HD mutation carriers, and premanifest from manifest HD.\r\n\r\nBDNF in CSF and plasma is unlikely to be a biomarker of HD progression, and urge caution in interpreting studies where conventional ELISA was used to quantify CSF BDNF."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/dc/terms/date> "2020-11-04" .
<https://discovery.ucl.ac.uk/id/document/1210142> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/org/ext-ea2decfc693f7d5f2f3e05ef391cb2ea> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-ea2decfc693f7d5f2f3e05ef391cb2ea> <http://xmlns.com/foaf/0.1/name> "MedRxiv"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-ea2decfc693f7d5f2f3e05ef391cb2ea> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c3de75e4d8b149ef5047caf2a2868a58> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114475#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10114475#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-c3de75e4d8b149ef5047caf2a2868a58> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c2c6438b801c86bff5401f2077ad1255> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114475#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10114475#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-c2c6438b801c86bff5401f2077ad1255> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-92faf507468c7376b76748d96de52055> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114475#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10114475#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-92faf507468c7376b76748d96de52055> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e9618232802bb4741c815e29217b46b9> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114475#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10114475#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-e9618232802bb4741c815e29217b46b9> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-82ec1f4c5d9f47da350c21be6464e38f> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114475#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10114475#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-82ec1f4c5d9f47da350c21be6464e38f> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4bc12ad25afdcef0d2c056ef4a48d5a7> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114475#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10114475#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-4bc12ad25afdcef0d2c056ef4a48d5a7> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-386ab99f4c5ddb12490422e45b5a546e> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114475#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10114475#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-386ab99f4c5ddb12490422e45b5a546e> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-eadccaf8cb8710a36683d092317843cc> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114475#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10114475#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-eadccaf8cb8710a36683d092317843cc> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-cabcdf66d980e03b89df3551e9f7d6dd> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114475#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10114475#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-cabcdf66d980e03b89df3551e9f7d6dd> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2f62fd1cb42a94b6f5506447cc1572f5> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114475#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10114475#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-2f62fd1cb42a94b6f5506447cc1572f5> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b000ea3715a51e62eb8b88fa8aa6e51a> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114475#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10114475#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-b000ea3715a51e62eb8b88fa8aa6e51a> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3bccfd2be84bf9e69733a61f90aa03c0> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10114475#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10114475#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-3bccfd2be84bf9e69733a61f90aa03c0> .
<https://discovery.ucl.ac.uk/id/person/ext-386ab99f4c5ddb12490422e45b5a546e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-386ab99f4c5ddb12490422e45b5a546e> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-386ab99f4c5ddb12490422e45b5a546e> <http://xmlns.com/foaf/0.1/familyName> "Arridge"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-386ab99f4c5ddb12490422e45b5a546e> <http://xmlns.com/foaf/0.1/name> "M Arridge"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e9618232802bb4741c815e29217b46b9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e9618232802bb4741c815e29217b46b9> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e9618232802bb4741c815e29217b46b9> <http://xmlns.com/foaf/0.1/familyName> "Tortelli"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e9618232802bb4741c815e29217b46b9> <http://xmlns.com/foaf/0.1/name> "R Tortelli"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3bccfd2be84bf9e69733a61f90aa03c0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-3bccfd2be84bf9e69733a61f90aa03c0> <http://xmlns.com/foaf/0.1/givenName> "EJ"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3bccfd2be84bf9e69733a61f90aa03c0> <http://xmlns.com/foaf/0.1/familyName> "Wild"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3bccfd2be84bf9e69733a61f90aa03c0> <http://xmlns.com/foaf/0.1/name> "EJ Wild"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c2c6438b801c86bff5401f2077ad1255> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c2c6438b801c86bff5401f2077ad1255> <http://xmlns.com/foaf/0.1/givenName> "LM"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c2c6438b801c86bff5401f2077ad1255> <http://xmlns.com/foaf/0.1/familyName> "Byrne"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c2c6438b801c86bff5401f2077ad1255> <http://xmlns.com/foaf/0.1/name> "LM Byrne"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-82ec1f4c5d9f47da350c21be6464e38f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-82ec1f4c5d9f47da350c21be6464e38f> <http://xmlns.com/foaf/0.1/givenName> "EB"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-82ec1f4c5d9f47da350c21be6464e38f> <http://xmlns.com/foaf/0.1/familyName> "Johnson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-82ec1f4c5d9f47da350c21be6464e38f> <http://xmlns.com/foaf/0.1/name> "EB Johnson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4bc12ad25afdcef0d2c056ef4a48d5a7> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4bc12ad25afdcef0d2c056ef4a48d5a7> <http://xmlns.com/foaf/0.1/givenName> "MS"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4bc12ad25afdcef0d2c056ef4a48d5a7> <http://xmlns.com/foaf/0.1/familyName> "Foiani"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4bc12ad25afdcef0d2c056ef4a48d5a7> <http://xmlns.com/foaf/0.1/name> "MS Foiani"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b000ea3715a51e62eb8b88fa8aa6e51a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b000ea3715a51e62eb8b88fa8aa6e51a> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b000ea3715a51e62eb8b88fa8aa6e51a> <http://xmlns.com/foaf/0.1/familyName> "Zetterberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b000ea3715a51e62eb8b88fa8aa6e51a> <http://xmlns.com/foaf/0.1/name> "H Zetterberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-92faf507468c7376b76748d96de52055> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-92faf507468c7376b76748d96de52055> <http://xmlns.com/foaf/0.1/givenName> "FB"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-92faf507468c7376b76748d96de52055> <http://xmlns.com/foaf/0.1/familyName> "Rodrigues"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-92faf507468c7376b76748d96de52055> <http://xmlns.com/foaf/0.1/name> "FB Rodrigues"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c3de75e4d8b149ef5047caf2a2868a58> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c3de75e4d8b149ef5047caf2a2868a58> <http://xmlns.com/foaf/0.1/givenName> "ZYA"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c3de75e4d8b149ef5047caf2a2868a58> <http://xmlns.com/foaf/0.1/familyName> "Ou"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c3de75e4d8b149ef5047caf2a2868a58> <http://xmlns.com/foaf/0.1/name> "ZYA Ou"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2f62fd1cb42a94b6f5506447cc1572f5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2f62fd1cb42a94b6f5506447cc1572f5> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2f62fd1cb42a94b6f5506447cc1572f5> <http://xmlns.com/foaf/0.1/familyName> "Heslegrave"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2f62fd1cb42a94b6f5506447cc1572f5> <http://xmlns.com/foaf/0.1/name> "A Heslegrave"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-eadccaf8cb8710a36683d092317843cc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-eadccaf8cb8710a36683d092317843cc> <http://xmlns.com/foaf/0.1/givenName> "E"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-eadccaf8cb8710a36683d092317843cc> <http://xmlns.com/foaf/0.1/familyName> "De Vita"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-eadccaf8cb8710a36683d092317843cc> <http://xmlns.com/foaf/0.1/name> "E De Vita"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cabcdf66d980e03b89df3551e9f7d6dd> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-cabcdf66d980e03b89df3551e9f7d6dd> <http://xmlns.com/foaf/0.1/givenName> "RI"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cabcdf66d980e03b89df3551e9f7d6dd> <http://xmlns.com/foaf/0.1/familyName> "Scahill"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cabcdf66d980e03b89df3551e9f7d6dd> <http://xmlns.com/foaf/0.1/name> "RI Scahill"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/WorkingPaperEPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> .
<https://discovery.ucl.ac.uk/id/eprint/10114475> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1210142> .
<https://discovery.ucl.ac.uk/id/document/1210142> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1210142> <http://www.w3.org/2000/01/rdf-schema#label> "Brain-derived neurotrophic factor in cerebrospinal fluid and plasma is not a biomarker for Huntington's disease (Text)"^^<http://www.w3.org/2001/XMLSchema#string> .
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